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公开(公告)号：WO2022226305A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025947
申请日：2022-04-22
Applicant: PRECISION BIOSCIENCES, INC. , UNIVERSITY OF MIAMI
Inventor： SMITH, James Jefferson , TOMBERLIN, Ginger , MORRIS, John , SHOOP, Wendy , MORAES, Carlos T.
Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
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公开(公告)号：WO2022076334A2
公开(公告)日：2022-04-14
申请号：PCT/US2021/053449
申请日：2021-10-05
Applicant: THE PROCTER & GAMBLE COMPANY
IPC: C11D3/386 , A61K8/66 , A61Q5/02 , C07K2319/21 , C11D11/0023 , C11D3/38618 , C11D3/38654 , C12N9/0069 , C12Y113/11
Abstract: Cleaning compositions having fatty acid alpha-dioxygenases and methods of using said compositions to provide a benefit by converting long chain fatty acids present in soils into 2-hydroperoxy fatty acids or terminal aldehydes.
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公开(公告)号：WO2021227200A1
公开(公告)日：2021-11-18
申请号：PCT/CN2020/097247
申请日：2020-06-19
Applicant: 广州中昱医学生物科技有限公司 , 王淋立
IPC: A61K38/48 , A61P1/02 , A61P31/04 , A61P31/02 , A61K8/99 , A61K8/66 , A61K8/64 , A61Q11/00 , A61Q17/00 , A61K38/40 , A61K38/44 , A61K38/47 , A61K38/46 , A61K35/744 , A61K35/747 , A61K35/742
Abstract: 一种口腔清洁组合物及其应用，包括蛋白水解酶蛋白、非蛋白水解酶蛋白和益生菌。口腔清洁组合物通过分解口腔残留物，破坏口腔有害细菌的生存环境，抑制口腔有害菌群生长的同时为口腔益生菌提供了良好的生长环境，间接或直接促进口腔益生菌的生长，从而维持良好的口腔环境，降低口腔疾病的发生。
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公开(公告)号：WO2021193569A1
公开(公告)日：2021-09-30
申请号：PCT/JP2021/011798
申请日：2021-03-22
Applicant: 高砂香料工業株式会社
IPC: A61Q11/00 , A61Q13/00 , C11D3/50 , A23L27/00 , A23L33/105 , A61K8/66 , A61K8/9789 , C11B9/02
Abstract: 本発明は、脱色後でも精油の風味変化が小さい、精油の脱色方法を提供することを解決すべき課題としている。本発明の第一実施形態は、精油を酸化する酸化工程を有する精油の脱色方法であって、前記酸化工程は、前記精油に水及びフェノール酸化酵素を添加する工程を有し、前記水の添加量が、前記精油１００質量部に対して、０．１～１０００質量部である、精油の脱色方法に関する。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2021186243A1
公开(公告)日：2021-09-23
申请号：PCT/IB2021/000149
申请日：2021-03-19
Applicant: SKINGEN INTERNATIONAL INC.
Inventor： BRYANT, David , GUILBAUD, Paul
IPC: A61K8/64 , A61K8/06 , A61K8/11 , A61K8/55 , A61K8/66 , A61K8/67 , A61K8/73 , A61K8/9789 , A61K8/99 , A61Q19/08 , C07K14/475
Abstract: Aqueous topical and transdermal skin care compositions comprising at least 5 recombinant human growth factors are disclosed. The compositions are useful for repairing and/or regenerating the skin, thereby improving its appearance and treating signs of aging due to various external factors (such as UV exposure). The recombinant human growth factors are selected from the group consisting of HGF, FG2, aFGF, IGF2, Mini EGF, IGF1, FGF-10, TGF-β3, PDGF, KGF, EGF-1, Stem Cell Factor, and Mini Noggin. Each growth factor, when present, is present in a concentration ranging from 0.001 to 1 wt. % of the overall composition.
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公开(公告)号：WO2021185783A1
公开(公告)日：2021-09-23
申请号：PCT/EP2021/056571
申请日：2021-03-15
Abstract: A dentifrice composition comprising an enzyme, a silica abrasive, carrageenan and a natural gum selected from gum karaya, guar gum, xanthan gum, gum arabic, gum tragacanth and mixtures thereof, in which the weight ratio of natural gum to carrageenan is from 1:3 to 1:1.
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8.发明申请
公开(公告)号：WO2021144211A1
公开(公告)日：2021-07-22
申请号：PCT/EP2021/050346
申请日：2021-01-11
Applicant: DANA, Jean Dominique
Inventor： DANA, Lou , JAZERON, Gildas
IPC: A61K8/02 , A61K8/66 , A61K38/43 , A61K38/44 , A61K38/46 , A61K38/47 , A61K38/54 , A61Q11/00 , A61K8/0216 , C12Y101/03004 , C12Y111/01007 , C12Y302/01003 , C12Y302/01026
Abstract: Un aspect de l’invention concerne un procédé de préparation d’une composition dentifrice, se présentant sous la forme d’une pastille comestible à sucer ou à mâcher et comportant : - Un complexe enzymatique comprenant les composés suivants : o invertase, o gluco oxydase, o amyloglucosidase, o lactoperoxydase, o lactoferrine, - au moins un agent gélifiant, caractérisé en ce qu’il comporte : - une étape de chauffage dudit au moins un agent gélifiant à une température comprise entre 82 et 88°C, - une étape d’encapsulation du complexe enzymatique par incorporation ou par ionisation dudit complexe enzymatique dans ledit au moins un agent gélifiant lorsque la température dudit au moins un agent gélifiant est comprise entre 55 et 65°C.
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公开(公告)号：WO2021011579A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042016
申请日：2020-07-14
Inventor： LIU, David, R. , BLUM, Travis, R.
Abstract: The disclosure provides amino acid sequence variants of Botulinum neurotoxin F (BoNT F) proteases that cleave SNARE proteins ( e.g. , VAMP1, VAMP7, etc. ) and methods of evolving the same. In some embodiments, proteases described by the disclosure are useful for cleaving proteins found in a cell, that is in an intracellular environment. In some embodiments, proteases described by the disclosure are useful for treating diseases associated with increased or aberrant VAMP7 expression or activity, for example, cancer, transplantation rejection, graft-versus-host disease, and neurological disorders. Some aspects of this disclosure provide methods for generating BoNT protease variants by continuous directed evolution.
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公开(公告)号：WO2020099663A1
公开(公告)日：2020-05-22
申请号：PCT/EP2019/081546
申请日：2019-11-15
Applicant: S-BIOMEDIC N.V.
Inventor： LOOD, Rolf
Abstract: The present application relates to the use of compositions comprising a live C. acnes strain secreting RoxP (radical oxygenase of Propionibacterium acnes ) and compositions comprising RoxP or a biologically active variant or fragment thereof for treating or preventing oxidative stress-associated skin diseases or for preventing or reducing skin ageing. The application further relates to method for diagnosing oxidative stress-associated skin disease in a subject or for determining the benefit a subject would receive from administration of RoxP or a live C. acnes strain secreting RoxP, the methods comprising determining the quantity of RoxP or the quantity of C. acnes in a skin sample from the subject.
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