公开(公告)号：WO2014009328A1

公开(公告)日：2014-01-16

申请号：PCT/EP2013/064422

申请日：2013-07-09

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： O'CONNELL, Kevin ,  BUCHANAN, Sandhya

IPC: A61K47/26 ,  A61K9/19

CPC classification number: A61K9/19 ,  A61K38/00 ,  A61K39/155 ,  A61K39/175 ,  A61K39/235 ,  A61K47/26 ,  A61K47/36 ,  A61K2039/5254 ,  C12N2710/10334 ,  C12N2760/18434 ,  C12N2760/18711

Abstract: The present invention pertains to a method for producing a medicinal product comprising a biologically active protein comprising the steps of providing an aqueous composition comprising a solvent, the biologically active protein and between 20% w/w and 60% w/w of a non-polymeric sugar, freezing the composition, thereby forming at least one frozen body comprising the solvent in frozen form, putting the frozen body in a drying apparatus while being carried by a support, the support comprising one or more restraining elements that define one or more boundaries of the support, wherein at most 30% of the surface of the body is contiguous with the one or more restraining elements, reducing the pressure in the drying apparatus below atmospheric pressure, providing heat to the body in order to sublimate the frozen solvent of the body and obtain a dried body. The invention also pertains to a product obtainable by this method.

Abstract translation: 本发明涉及一种生产包含生物活性蛋白质的药用产品的方法，包括以下步骤：提供包含溶剂，生物活性蛋白质和20％w / w至60％w / w的非水性组合物的水性组合物， 聚合糖，冷冻组合物，从而形成至少一个包含冷冻形式的溶剂的冷冻体，将冷冻的身体放在干燥装置中同时被支撑物携带，所述支撑体包括限定一个或多个边界的一个或多个约束元件 的载体，其中至少30％的身体表面与一个或多个限制元件邻接，将干燥装置中的压力降低到大气压力以下，为身体提供热量，以便使冷冻溶剂升华 身体并获得干燥的身体。 本发明还涉及通过该方法可获得的产品。

公开(公告)号：WO2014140239A1

公开(公告)日：2014-09-18

申请号：PCT/EP2014/055053

申请日：2014-03-14

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： EDDY, Brad ,  QIAO, Zhisong ,  O'CONNELL, Kevin

IPC: A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K39/295 ,  A61K39/265 ,  A61K35/76 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/02 ,  A61K39/0208 ,  A61K39/102 ,  A61K39/12 ,  A61K39/155 ,  A61K39/215 ,  A61K39/245 ,  A61K39/265 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2760/12234 ,  C12N2760/18034 ,  C12N2760/18634 ,  C12N2770/20034 ,  C12N2770/24333 ,  C12N2770/24334

Abstract: The present invention discloses liquid stable bovine vaccines that comprise a live attenuated virus, and a sugar alcohol. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.

Abstract translation: 本发明公开了包含活减毒病毒和糖醇的液体稳定的牛疫苗。 本发明还公开了通过这种疫苗的施用来制备这种疫苗和保护动物的方法。

公开(公告)号：WO2018108772A1

公开(公告)日：2018-06-21

申请号：PCT/EP2017/082139

申请日：2017-12-11

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： O'CONNELL, Kevin ,  VAIDYANATHAN, Subramaniam ,  EDDY, Brad

IPC: A61K39/102 ,  A61K47/32 ,  A61K9/19 ,  A61K39/00

Abstract: The present invention relates to an oral vaccine against respiratory disease in ruminants, comprising live attenuated Mannheimia haemolytica bacteria and a Polyvinylpyrrolidone (PVP). The addition of PVP significantly improves the protective effect of vaccination on lung scores after a challenge infection. Further the PVP allows vaccination by a method of mass administration, such as by oral route via a drink. In addition the invention relates to methods for the preparation of such a vaccine, to methods for the vaccination of ruminants employing such a vaccine, and to medical uses of a composition comprising M. haemolytica bacteria.

公开(公告)号：WO2015124594A1

公开(公告)日：2015-08-27

申请号：PCT/EP2015/053364

申请日：2015-02-18

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： O'CONNELL, Kevin ,  QIAO, Zhisong ,  EDDY, Brad ,  STRAIT, Erin

IPC: A61K39/12

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K39/12 ,  A61K39/145 ,  A61K39/225 ,  A61K47/183 ,  A61K47/32 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N2760/16034 ,  C12N2770/10034 ,  C12N2770/20034

Abstract: The present invention is drawn to liquid stable swine vaccines that comprise a live porcine virus. The invention is also drawn to the manufacture of such vaccines and methods of vaccinating animal subjects with these vaccines.

Abstract translation: 本发明涉及包含活猪病毒的液体稳定的猪疫苗。 本发明还涉及这些疫苗的制造和用这些疫苗接种动物受试者的方法。

公开(公告)号：WO2015121463A2

公开(公告)日：2015-08-20

申请号：PCT/EP2015/053188

申请日：2015-02-16

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： QIAO, Zhisong ,  COOK, Stephanie ,  O'CONNELL, Kevin ,  TARPEY, Ian

IPC: A61K39/12

CPC classification number: A61K39/215 ,  A61K9/0019 ,  A61K39/12 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20034

Abstract: The present invention is drawn to liquid stable poultry vaccines that comprise avian virus. The invention is also drawn to the manufacture of such vaccines methods of vaccinating animal subjects with these vaccines.

Abstract translation: 本发明涉及包含禽流感病毒的液体稳定的家禽疫苗。 本发明还涉及制造用这些疫苗给动物对象接种疫苗的方法。

公开(公告)号：WO2014029702A1

公开(公告)日：2014-02-27

申请号：PCT/EP2013/067169

申请日：2013-08-16

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： O'CONNELL, Kevin ,  QIAO, Zhisong

IPC: A61K39/295 ,  A61K39/175 ,  A61K39/235 ,  A61K39/23 ,  A61K39/145

CPC classification number: A61K39/235 ,  A61K9/08 ,  A61K39/0225 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/175 ,  A61K39/23 ,  A61K47/10 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/42 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/10034 ,  C12N2750/14034 ,  C12N2750/14322 ,  C12N2760/18034 ,  C12N2760/18434 ,  C12N2760/18634

Abstract: The present invention discloses liquid stable vaccines that comprise a live attenuated virus, 10-30% sugar additive, and an amino acid. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.

Abstract translation: 本发明公开了包含活减毒病毒，10-30％糖添加剂和氨基酸的液体稳定疫苗。 本发明还公开了通过这种疫苗的施用来制备这种疫苗和保护动物的方法。

公开(公告)号：WO2015044337A2

公开(公告)日：2015-04-02

申请号：PCT/EP2014/070608

申请日：2014-09-26

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： QIAO, Zhisong ,  O'CONNELL, Kevin

IPC: A61K39/29

CPC classification number: A61K9/1623 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1658 ,  A61K39/12 ,  A61K39/155 ,  A61K39/175 ,  A61K39/23 ,  A61K39/235 ,  A61K39/295 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N7/00 ,  C12N2710/10034 ,  C12N2710/10334 ,  C12N2710/10371 ,  C12N2750/14034 ,  C12N2750/14071 ,  C12N2750/14322 ,  C12N2750/14334 ,  C12N2760/18034 ,  C12N2760/18071 ,  C12N2760/18434 ,  C12N2760/18471

Abstract: The present invention discloses dry formulations of room temperature stable vaccines that comprise a live attenuated virus, a sugar stabilizer, and an amino acid stabilizer. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.

Abstract translation: 本发明公开了包含活减毒病毒，糖稳定剂和氨基酸稳定剂的室温稳定疫苗的干燥制剂。 本发明还公开了通过施用此类疫苗来保护动物的这种疫苗和方法的制造。