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1.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA METHYL-ESTER SHIELDED CARBON CHAIN ELONGATION 审中-公开通过甲基酯保护的碳链延长生产7-碳化合物的方法
公开(公告)号：WO2014105794A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077420
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
IPC: C12P7/18
CPC classification number: C12P13/001 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
Abstract translation: 该文献描述了通过形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生物化学途径 在C7脂肪族主链底物中。 本文描述的这些途径，代谢工程和培养策略依赖于接受甲酯保护的二羧酸底物的酶或同系物。
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2.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS FROM LONG CHAIN FATTY ACIDS VIA OXIDATIVE CLEAVAGE 审中-公开通过氧气消毒从长链脂肪酸生产7碳化合物的方法
公开(公告)号：WO2014105793A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/077419
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis .
Abstract translation: 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于脂肪酸合成途径以及通过单氧酶（例如细胞色素P450）如长链酰基 - [acp]中间体的氧化裂解，例如由BioI从微生物如枯草芽孢杆菌 。
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3.发明申请METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 审中-公开通过与碳储存相关的辅助碳链延伸生产6碳化合物的方法
公开(公告)号：WO2014093865A2
公开(公告)日：2014-06-19
申请号：PCT/US2013/075087
申请日：2013-12-13
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
CPC classification number: C12N9/0008 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/02001
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延长酶或类似物与聚羟基链烷酸酯累积细菌的碳储存途径相关的酶。
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公开(公告)号：WO2014105796A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077423
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
IPC: C12P7/18
CPC classification number: C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
Abstract translation: 该文献描述了通过形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇的生物化学途径， 在由分支酸酯或苯甲酸酯制备的C7脂族主链底物中。 本文所述的这些途径，代谢工程和培养策略依赖于厌氧苯甲酰-CoA降解途径酶。
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公开(公告)号：WO2015017404A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/048606
申请日：2014-07-29
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： CONRADIE, Alex Van Eck , BOTES, Adriana Leonora
CPC classification number: C12P19/32 , C12N9/1029 , C12P7/26 , C12P7/40 , C12Y203/01016
Abstract: This document describes biochemical pathways that include the production of 3-oxopent-4-enoyl-CoA by condensation of acryloyl-CoA and acetyl-CoA using a β-ketothiolase with a SER-HIS-HIS catalytic triad. These pathways described herein rely on enzymes such as, inter alia, dehydrogenases, dehydratases and β-ketothiolases .
Abstract translation: 本文件描述了生物化学途径，其包括通过使用α-氧化还原酶与SER-HIS-HIS催化三单元组缩合丙烯酰辅酶A和乙酰辅酶A来生产3-氧代-4-烯酰辅酶A。 本文描述的这些途径依赖于酶，例如脱氢酶，脱水酶和β-酮硫解酶。
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Patent Agency Ranking6.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA PYRUVATE AND SUCCINATE SEMIALDEHYDE ALDOL CONDENSATION 审中-公开生产七碳化合物的方法通过吡咯烷酸和己二酸二乙醇醇缩合反应
公开(公告)号：WO2014105797A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077430
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
Abstract translation: 本文件描述了通过在羧基，胺或羟基中形成一个或两个末端官能团，生成一种或多种庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇的生化途径 由琥珀酸半醛或丙酮酸生成的C7脂肪族主链基质。 本文描述的这些途径，代谢工程和培养策略依赖于琥珀酸半醛和丙酮酸的醛醇缩合。
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7.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 审中-公开通过与碳存储相关的与CoA相关的碳链延长生产7-碳化合物的方法
公开(公告)号：WO2014093847A2
公开(公告)日：2014-06-19
申请号：PCT/US2013/075058
申请日：2013-12-13
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC: C12P7/18
CPC classification number: C12P13/005 , C12N9/1029 , C12N9/93 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-hydroxyheptanoic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the CoA-dependent elongation enzymes or analog enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-羟基庚酸，7-氨基庚酸，七亚甲基二胺或1,7-庚二醇的生物化学途径 在C7脂肪族主链底物中。 本文描述的这些途径，代谢工程和培养策略依赖于与来自聚羟基链烷酸酯积累细菌的碳存储途径相关的CoA依赖性延伸酶或类似酶。
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公开(公告)号：WO2015031653A3
公开(公告)日：2015-03-05
申请号：PCT/US2014/053222
申请日：2014-08-28
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
Abstract: This document describes biochemical pathways for producing methacrylate from precursors such as pyruvate via isobutyraldehyde and isobutyryl-CoA, using enzymes such as one or more thioesterases, transferases, or dehydrogenases, as well as recombinant hosts expressing one or more of such enzymes.
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9.发明申请METHODS OF PRODUCING 6-CARBON CHEMICALS VIA METHYL-ESTER SHIELDED CARBON CHAIN ELONGATION 审中-公开通过甲基酯保护的碳链延长生产6-碳化合物的方法
公开(公告)号：WO2014105805A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077445
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
CPC classification number: C12P13/005 , C12N9/1096 , C12N9/16 , C12N9/86 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/02 , C12Y206/01 , C12Y301/02
Abstract: This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
Abstract translation: 该文献描述了通过形成一个或两个末端官能团来生产己二酸，6-氨基己酸，6-羟基己酸，六亚甲基二胺，己内酰胺或1,6-己二醇的生物化学途径，所述末端官能团由羧基 ，胺或羟基，在C6脂族主链底物中。 本文描述的这些途径，代谢工程和培养策略依赖于接受甲酯保护的二羧酸底物的酶或同系物。
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10.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS 审中-公开通过C1碳链延伸生产碳 - 碳化合物的方法与乙酰乙酸乙酯合成相关
公开(公告)号：WO2014105790A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077413
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
IPC: C12P7/18
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
Abstract translation: 该文件描述了通过形成一个或两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生物化学途径，所述末端官能团各自包含羧基，胺 或羟基，在C7脂族主链底物中。 这里描述的这些途径，代谢工程和培养策略依赖于C1延伸酶或与辅酶B生物合成相关的同源物。
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