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公开(公告)号：WO2019191767A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025202
申请日：2019-04-01
Inventor： SMITH, Gary J. , PEARLMAN, Paul S. , KIRBY, Gregory S.
Abstract: Provided herein are systems and methods for recycling and supplementing off-gas from a gas fed reaction process. The systems and methods are particularly useful for bioprocesses that convert hydrogen gas into one or more biosynthetic products. By maintaining separate hydrogen and oxygen feed gas streams, and forming a recycle gas that introduces a target component of the supply gas to the bioreactor within a target concentration range, the yields, productivities, and safety profiles of the bioprocess can be enhanced.
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公开(公告)号：WO2019191763A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025194
申请日：2019-04-01
Inventor： SMITH, Gary J. , PEARLMAN, Paul S. , KIRBY, Gregory S.
Abstract: The present disclosure provides methods for controlling oxygen concentration during aerobic biosynthesis, e.g., fermentation. The method may comprise feeding an oxygen-containing gas into a vessel including a fermentation feedstock and reacting the fermentation feedstock with the oxygen-containing gas to form a broth including a gaseous phase dispersed within the broth. The gaseous phase may comprise any unreacted oxygen from the oxygen-containing gas. The method further includes reducing the concentration of the unreacted oxygen in the dispersed gaseous phase to less than the limiting oxygen concentration ("LOC") for flammability before separating the gaseous phase from the fermentation broth. The concentration of the unreacted oxygen in the gaseous phase is reduced by employing oxygen removal schemes or oxygen dilution schemes.
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3.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA PYRUVATE AND SUCCINATE SEMIALDEHYDE ALDOL CONDENSATION 审中-公开生产七碳化合物的方法通过吡咯烷酸和己二酸二乙醇醇缩合反应
公开(公告)号：WO2014105797A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077430
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
Abstract translation: 本文件描述了通过在羧基，胺或羟基中形成一个或两个末端官能团，生成一种或多种庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇的生化途径 由琥珀酸半醛或丙酮酸生成的C7脂肪族主链基质。 本文描述的这些途径，代谢工程和培养策略依赖于琥珀酸半醛和丙酮酸的醛醇缩合。
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公开(公告)号：WO2014105796A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077423
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
IPC: C12P7/18
CPC classification number: C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
Abstract translation: 该文献描述了通过形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇的生物化学途径， 在由分支酸酯或苯甲酸酯制备的C7脂族主链底物中。 本文所述的这些途径，代谢工程和培养策略依赖于厌氧苯甲酰-CoA降解途径酶。
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5.发明申请BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS 审中-公开用于生产尼龙-7，尼龙-7,7和聚酯的生物反应过程
公开(公告)号：WO2013096898A2
公开(公告)日：2013-06-27
申请号：PCT/US2012/071472
申请日：2012-12-21
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： PEARLMAN, Paul S. , CHEN, Changlin , BOTES, Adriana , CONRADIE, Alex Van Eck
IPC: C12P13/02
CPC classification number: C12P13/02 , C08G69/08 , C08G69/26 , C12N15/52 , C12P7/40 , C12P7/44 , C12P7/50 , C12P13/001 , C12P13/005 , C12P13/04 , C12P17/10
Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
Abstract translation: 本发明的实施方案涉及在分离的酶存在下或在表达这些酶的重组宿主细胞存在下生物合成二官能或三官能C7烷烃的方法。 二 - 或三官能C7烷烃可用作生产尼龙-7，尼龙-7，x，尼龙-X，7和聚酯的中间体。
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Patent Agency Ranking
公开(公告)号：WO2020060970A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/051401
申请日：2019-09-17
Applicant: INVISTA NORTH AMERICA S.A.R.L. , SMITH, Gary J. , PEARLMAN, Paul S. , KIRBY, Gregory S. , ROSIN, Richard R. , SCHULZ, Taylor Craig , SARGENT, Michael James
Inventor： SMITH, Gary J. , PEARLMAN, Paul S. , KIRBY, Gregory S. , ROSIN, Richard R. , SCHULZ, Taylor Craig , SARGENT, Michael James
IPC: B01J39/05 , C07C209/84 , C07C209/86 , C12P13/00 , C07C211/12 , C07C211/09
Abstract: The present disclosure generally relates to methods for the recovery of amines from aqueous mixtures. In particular, the disclosure relates to methods for separating amines from amine-containing aqueous mixtures by adjusting the pH of the aqueous mixture relative to the highest pKa value for the amines.
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公开(公告)号：WO2019191772A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025218
申请日：2019-04-01
Inventor： FOSTER, Alexander Brett , KENNEDY, Jonathan , PEARLMAN, Paul S.
Abstract: This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19. Specifically, 7-aminoheptanoic acid is produced using a transaminase from Chromobacterium violaceum from pimelate semialdehyde using alanine, GABA (gamma aminobutyric acid) or 6-ACA as amino donors.
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8.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS VIA METHYL-ESTER SHIELDED CARBON CHAIN ELONGATION 审中-公开通过甲基酯保护的碳链延长生产7-碳化合物的方法
公开(公告)号：WO2014105794A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/077420
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
IPC: C12P7/18
CPC classification number: C12P13/001 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
Abstract translation: 该文献描述了通过形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生物化学途径 在C7脂肪族主链底物中。 本文描述的这些途径，代谢工程和培养策略依赖于接受甲酯保护的二羧酸底物的酶或同系物。
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9.发明申请METHODS OF PRODUCING 7-CARBON CHEMICALS FROM LONG CHAIN FATTY ACIDS VIA OXIDATIVE CLEAVAGE 审中-公开通过氧气消毒从长链脂肪酸生产7碳化合物的方法
公开(公告)号：WO2014105793A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/077419
申请日：2013-12-23
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , CHEN, Changlin , PEARLMAN, Paul S.
CPC classification number: C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis .
Abstract translation: 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于脂肪酸合成途径以及通过单氧酶（例如细胞色素P450）如长链酰基 - [acp]中间体的氧化裂解，例如由BioI从微生物如枯草芽孢杆菌 。
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公开(公告)号：WO2013082542A2
公开(公告)日：2013-06-06
申请号：PCT/US2012/067463
申请日：2012-11-30
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： PEARLMAN, Paul S. , CHEN, Changlin , BOTES, Adriana , CONRADIE, Alex Van Eck
IPC: C12N9/00
CPC classification number: C12P5/026 , C12N9/0004 , C12N9/88 , C12N15/52 , C12Y401/01033 , C12Y402/03027 , Y02E50/343
Abstract: This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
Abstract translation: 本文件描述了通过在丁二烯合成底物中形成两个乙烯基基团来生产丁二烯的生物化学途径。 本文所述的这些途径依赖于酶，例如甲羟戊酸二磷酸脱羧酶，异戊二烯合酶和脱水酶用于最后的酶促步骤。
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