公开(公告)号：WO2015195678A1

公开(公告)日：2015-12-23

申请号：PCT/US2015/036050

申请日：2015-06-16

Applicant: INVISTA Technologies S.à r.l.

Inventor： BOTES, Adriana Leonora ,  CONRADIE, Alex Van Eck ,  HADDOUCHE, Ramdane

IPC: C12P7/42

CPC classification number: C12P13/001 ,  C07C47/02 ,  C07C47/12 ,  C07C59/01 ,  C07C59/325 ,  C07C223/02 ,  C08G63/06 ,  C12N9/0008 ,  C12N9/0077 ,  C12N9/1007 ,  C12N9/1096 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y102/99006 ,  C12Y114/15001 ,  C12Y114/15003 ,  C12Y206/01018 ,  C12Y206/01019 ,  C12Y206/01029 ,  C12Y206/01048 ,  C12Y206/01082

Abstract: This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase , an alcohol O-acetyltransferase , and a monooxygenase , as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.

Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，醇O-乙酰转移酶和单加氧酶来生产7-羟基庚酸甲酯和庚酸庚酯的生物化学途径，以及表达一种或多种这样的 外源酶。 7-羟基庚酸甲酯和庚酸庚酯可以酶促转化成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇。