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1.发明申请A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES 审中-公开用于生产来自可再生资源的化合物的高产量路线
公开(公告)号：WO2015042201A3
公开(公告)日：2015-06-04
申请号：PCT/US2014056175
申请日：2014-09-17
Applicant: ZYMOCHEM INC , CHOKHAWALA HARSHAL
Inventor： CHOKHAWALA HARSHAL
IPC: C12P7/40
CPC classification number: C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/343
Abstract: Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear -alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 -hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 -hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
Abstract translation: 本文提供的方法，组合物和非天然存在的微生物用于制备化合物，例如1-丁醇，丁酸，琥珀酸，1,4-丁二醇，1-戊醇，戊酸，戊二酸，1,5-戊二醇， 1-己醇，己酸，己二酸，1,6-己二醇，6-羟基己酸，ε-己内酯，6-氨基己酸，ε-己内酰胺，六亚甲基二胺，线性脂肪酸和线性脂肪醇， 长度为6-24个碳原子的直链烷烃和直链烷烃，癸二酸和十二烷二酸包括：a）通过醛醇缩合将CN醛和丙酮酸盐转化成CN + 3-羟基酮中间体; 和b）通过酶促步骤或酶和化学步骤的组合将CN + 3-羟基酮中间体转化为化合物。
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公开(公告)号：WO2015195682A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036057
申请日：2015-06-16
Applicant: INVISTA TECHNOLOGIES S.À.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , HADDOUCHE, Ramdane
CPC classification number: C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
Abstract: This document describes biochemical pathways for producing 6- hydroxyhexanoate methyl ester and hexanoic acid hexyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase and a monooxygenase , as well as recombinant hosts expressing one or more of such enzymes. 6-hydroxyhexanoate methyl esters and hexanoic acid hexyl ester can be enzymatically converted to adipic acid, adipate semialdehyde, 6-aminohexanoate, 6-hydroxyhexanoate, hexamethylenediamine, and 1,6-hexanediol.
Abstract translation: 该文献描述了使用一种或多种脂肪酸O-甲基转移酶，醇O-乙酰转移酶和单加氧酶产生6-羟基己酸甲酯和己酸己酯的生化途径，以及表达一种或多种这样的酶的重组宿主 。 6-羟基己酸甲酯和己酸己酯可以酶促转化为己二酸，己二酸半醛，6-氨基己酸，6-羟基己酸，六亚甲基二胺和1,6-己二醇。
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公开(公告)号：WO2015195678A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036050
申请日：2015-06-16
Applicant: INVISTA Technologies S.à r.l.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , HADDOUCHE, Ramdane
IPC: C12P7/42
CPC classification number: C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
Abstract: This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase , an alcohol O-acetyltransferase , and a monooxygenase , as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，醇O-乙酰转移酶和单加氧酶来生产7-羟基庚酸甲酯和庚酸庚酯的生物化学途径，以及表达一种或多种这样的 外源酶。 7-羟基庚酸甲酯和庚酸庚酯可以酶促转化成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇。
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4.发明申请A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES 审中-公开用于生产来自可再生资源的化合物的高产量路线
公开(公告)号：WO2015042201A2
公开(公告)日：2015-03-26
申请号：PCT/US2014/056175
申请日：2014-09-17
Applicant: ZYMOCHEM INC. , CHOKHAWALA, Harshal
Inventor： CHOKHAWALA, Harshal
CPC classification number: C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/343
Abstract: Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear -alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a C N aldehyde and pyruvate to a C N+3 -hydroxyketone intermediate through an aldol addition; and b) converting the C N+3 -hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
Abstract translation: 本文提供的方法，组合物和非天然存在的微生物用于制备化合物，例如1-丁醇，丁酸，琥珀酸，1,4-丁二醇，1-戊醇，戊酸，戊二酸，1,5-戊二醇， 1-己醇，己酸，己二酸，1,6-己二醇，6-羟基己酸，ε-己内酯，6-氨基己酸，ε-己内酰胺，六亚甲基二胺，直链脂肪酸和直链脂肪醇， 长度在7-25个碳原子之间，直链烷烃和6-24个碳原子的直链烷烃，癸二酸和十二烷二酸包括：a）通过醛醇缩合将CN醛和丙酮酸酯转化为CN + 3-羟基酮中间体; 和b）通过酶促步骤或酶和化学步骤的组合将CN + 3-羟基酮中间体转化为化合物。
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5.发明申请MUTANT MICROORGANISM HAVING HIGH PRODUCTION OF CADAVERINE, AND PREPARATION METHOD OF CADAVERINE USING SAME 审中-公开具有高生产率的复方微生物，以及使用其的CADAVERINE的制备方法
公开(公告)号：WO2012018226A3
公开(公告)日：2012-05-24
申请号：PCT/KR2011005709
申请日：2011-08-03
Applicant: KOREA ADVANCED INST SCI & TECH , LEE SANG YUP , QIAN ZHI GANG , XIA XIAOXIA , KIM MIN YOUNG
Inventor： LEE SANG YUP , QIAN ZHI GANG , XIA XIAOXIA , KIM MIN YOUNG
CPC classification number: C12N15/70 , C12N9/001 , C12N9/1029 , C12N9/104 , C12N9/1085 , C12N9/1096 , C12N9/88 , C12N9/93 , C12N15/52 , C12P13/001 , C12Y103/01026 , C12Y203/01057 , C12Y205/01016 , C12Y206/01082 , C12Y401/0102 , C12Y402/01051 , C12Y403/03007
Abstract: The present invention relates to a mutant microorganism having a high production of cadaverine, a preparation method of cadaverine using the same, and more specifically, to a mutant microorganism having a high production of cadaverine in which a gene involved in the degradation or use pathway of cadaverine is weakened or deleted, and a method for preparing putrescine in a high yield by cultivating the same under aerobic conditions. According to the present invention, the mutant microorganism having a high production of cadaverine is useful for preparing cadaverine, which is widely used by industries, in a high yield.
Abstract translation: 本发明涉及具有高生产性的尸胺的突变体微生物，使用其的尸胺的制备方法，更具体地，涉及具有高生产性的尸胺的突变微生物，其中参与降解或使用途径的基因 尸体被削弱或缺失，以及通过在有氧条件下培养来制备高产率腐胺的方法。 根据本发明，具有高生产性的尸胺的突变型微生物可用于制备高产量被工业广泛使用的雄蕊素。
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Patent Agency Ranking
公开(公告)号：WO2015195654A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036015
申请日：2015-06-16
Applicant: INVISTA TECHNOLOGIES S.A R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
CPC classification number: C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
Abstract: This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，CoA转移酶和CoA连接酶从前体如2-氧戊二酸生产2,3-脱氢阿迪普基-CoA甲酯的生物化学途径，以及 表达一种或多种此类酶的重组宿主。 可以使用反式-2-烯酰辅酶A还原酶将2,3-脱氢脱苄基-CoA甲酯酶促转化为己二酰CoA，甲酯酶又可以酶促转化为己二酸，6-氨基己酸6-羟基己酸酯 ，己内酰胺，六亚甲基二胺或1,6-己二醇。
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公开(公告)号：WO2012018226A2
公开(公告)日：2012-02-09
申请号：PCT/KR2011/005709
申请日：2011-08-03
CPC classification number: C12N15/70 , C12N9/001 , C12N9/1029 , C12N9/104 , C12N9/1085 , C12N9/1096 , C12N9/88 , C12N9/93 , C12N15/52 , C12P13/001 , C12Y103/01026 , C12Y203/01057 , C12Y205/01016 , C12Y206/01082 , C12Y401/0102 , C12Y402/01051 , C12Y403/03007
Abstract: 본 발명은 카다베린 고생성능을 가지는 변이 미생물 및 이를 이용한 카다베린의 제조방법에 관한 것으로, 보다 구체적으로는 카다베린(cadaverine)의 분해 또는 이용 경로에 관여하는 유전자가 약화 또는 결실되어 있는 카다베린 고생성능을 가지는 변이 미생물 및 이를 호기조건하에서 배양하여 퓨트레신을 고수율로 제조하는 방법에 관한 것이다. 본 발명에 따른 카다베린 고생성능을 가지는 변이 미생물은 산업적으로 널리 사용되는 카다베린을 고수율로 제조하는데 유용하다.
Abstract translation: 本发明涉及具有高产糖能力的突变微生物和使用该微生物生产尸胺的方法，更具体地，本发明涉及一种生产尸胺 - 本发明还涉及具有减弱或缺失的甘氨酸的降解活性的突变微生物以及通过在需氧条件下培养它以高产率生产腐胺的方法。 根据本发明的具有尸胺介导性能的突变微生物可用于以高产率生产工业上广泛使用的尸胺。
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公开(公告)号：WO2015195611A3
公开(公告)日：2016-03-31
申请号：PCT/US2015035947
申请日：2015-06-16
Applicant: INVISTA TECHNOLOGIES S À R L
Inventor： BOTES ADRIANA LEONORA , CONRADIE ALEX VAN ECK
CPC classification number: C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
Abstract: This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，硫酸酯酶等从前体例如2-氧代 - 戊二酸，乙酰辅酶A或琥珀酰-CoA制备2（E） - 庚二酰辅酶A甲酯的生化途径， CoA转移酶，CoA连接酶，以及表达一种或多种这样的酶的重组宿主。 2（E） - 庚二酰辅酶A甲酯可以使用反式-2-烯酰辅酶A还原酶和甲酯酶酶转化为双甲酰基-CoA。 可将Pimeloyl-CoA酶促转化成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇。
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公开(公告)号：WO2015195695A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036074
申请日：2015-06-16
Applicant: INVISTA TECHNOLOGIES S.Á.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , HADDOUCHE, Ramdane
IPC: C12P7/42
CPC classification number: C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
Abstract: This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol.
Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，醇O-乙酰转移酶和单加氧酶来生产5-羟基戊酸甲酯和戊酸戊酯的生物化学途径，以及表达一种或多种这样的一种或多种 外源酶。 5-羟基戊酸甲酯和戊酸戊酯可以酶促转化成戊二酸，5-氨基戊酸，5-羟基戊酸，尸胺或1,5-戊二醇。
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公开(公告)号：WO2015195611A2
公开(公告)日：2015-12-23
申请号：PCT/US2015/035947
申请日：2015-06-16
Applicant: INVISTA TECHNOLOGIES S.À.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
CPC classification number: C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
Abstract: This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase , as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase , and a methylesterase . Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，硫酸酯酶等从前体例如2-氧代 - 戊二酸，乙酰辅酶A或琥珀酰-CoA制备2（E） - 庚二酰辅酶A甲酯的生化途径， CoA转移酶，CoA连接酶，以及表达一种或多种这样的酶的重组宿主。 2（E） - 庚二酰辅酶A甲酯可以使用反式-2-烯酰辅酶A还原酶和甲酯酶酶转化为双甲酰基-CoA。 可将Pimeloyl-CoA酶促转化成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇。
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