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公开(公告)号：WO2007137301A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069587
申请日：2007-05-23
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W , MURRAY SUSAN F
Inventor： BHANOT SANJAY , DOBIE KENNETH W , MURRAY SUSAN F
IPC: A61K48/00
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/322 , C12N2310/341 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions, and methods for modulating the expression of ChREBP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and conditions.
Abstract translation: 本文公开了用于调节细胞，组织或动物中ChREBP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：WO2007062380A3
公开(公告)日：2007-10-04
申请号：PCT/US2006061175
申请日：2006-11-21
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W , JAIN RAVI
Inventor： BHANOT SANJAY , DOBIE KENNETH W , JAIN RAVI
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
Abstract translation: 提供了用于调节eIF4E-BP2表达的化合物，组合物和方法。 该组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达以及诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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公开(公告)号：WO2005113016A3
公开(公告)日：2006-05-04
申请号：PCT/US2005014116
申请日：2005-04-21
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W
Inventor： BHANOT SANJAY , DOBIE KENNETH W
IPC: A61K31/70 , A61K48/00 , C07H21/04 , C12N15/113
CPC classification number: C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
Abstract: Compositions and methods are provided for decreasing blood glucose levels in an animal, comprising administering to said animal an antisense inhibitor of glucose-6-phosphatase translocase expression alone or in combination with at least one glucose-lowering drug. Also provided are compositions and methods for treating diabetes and other metabolic disorders.
Abstract translation: 提供了用于降低动物体内血糖水平的组合物和方法，其包括向所述动物施用单独的葡萄糖-6-磷酸酶转位酶表达的反义抑制剂或与至少一种葡萄糖降低药物组合。 还提供了用于治疗糖尿病和其它代谢紊乱的组合物和方法。
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公开(公告)号：WO2004005461A3
公开(公告)日：2004-11-04
申请号：PCT/US0320309
申请日：2003-06-25
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W
Inventor： BHANOT SANJAY , DOBIE KENNETH W
CPC classification number: C12N15/1136 , A61K38/00 , C07H21/04 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding insulin-like growth factor 2. Methods of using these compounds for modulation of insulin-like growth factor 2 expression and for treatment of diseases associated with expression of insulin-like growth factor 2 are provided.
Abstract translation: 提供反义化合物，组合物和方法用于调节胰岛素样生长因子2的表达。组合物包含靶向编码胰岛素样生长因子2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节 提供胰岛素样生长因子2表达和用于治疗与胰岛素样生长因子2的表达相关的疾病。
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公开(公告)号：WO2004071407A2
公开(公告)日：2004-08-26
申请号：PCT/US2004002003
申请日：2004-02-06
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , COWSERT LEX M , WYATT JACQUELINE R , FREIER SUSAN M , MONIA BRETT P , BUTLER MADELINE M , MCKAY ROBERT , DOBIE KENNETH W
Inventor： BHANOT SANJAY , COWSERT LEX M , WYATT JACQUELINE R , FREIER SUSAN M , MONIA BRETT P , BUTLER MADELINE M , MCKAY ROBERT , DOBIE KENNETH W
IPC: A61K20060101 , A61K38/00 , A61K48/00 , C12N5/02 , C12N15/113 , A61K
CPC classification number: C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
Abstract translation: 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2005019418A8
公开(公告)日：2008-01-17
申请号：PCT/US2004024384
申请日：2004-08-18
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W , YU XING-XIAN
Inventor： BHANOT SANJAY , DOBIE KENNETH W , YU XING-XIAN
IPC: C07H21/02 , C12N15/113
CPC classification number: C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
Abstract translation: 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：WO2005071080A3
公开(公告)日：2006-01-19
申请号：PCT/US2005002431
申请日：2005-01-20
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W , FREIER SUSAN M , DEAN NICHOLAS M , BENNETT C FRANK
Inventor： BHANOT SANJAY , DOBIE KENNETH W , FREIER SUSAN M , DEAN NICHOLAS M , BENNETT C FRANK
IPC: A61K38/00 , C12N15/113 , C12Q1/68 , C12N15/11 , A61K31/7088 , A61P3/00 , C07H21/00
CPC classification number: C07H21/04 , A61K38/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for diagnosis and treatment of diseases and conditions associated with expression of glucocorticoid receptor are provided.
Abstract translation: 提供化合物，组合物和方法用于调节糖皮质激素受体的表达。 组合物包含靶向编码糖皮质激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节糖皮质激素受体表达和诊断和治疗与糖皮质激素受体表达相关的疾病和病症的方法。
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公开(公告)号：WO2006127976A3
公开(公告)日：2007-02-15
申请号：PCT/US2006020388
申请日：2006-05-24
Applicant: ISIS PHARMACEUTICALS INC , MCKAY ROBERT , JAIN RAVI , DOBIE KENNETH W , PANDEY SANJAY K , BHANOT SANJAY
Inventor： MCKAY ROBERT , JAIN RAVI , DOBIE KENNETH W , PANDEY SANJAY K , BHANOT SANJAY
CPC classification number: C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart diseaseby administration of antisense compounds targeted to PTPRU.
Abstract translation: 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予靶向PTPRU的反义化合物的冠心病。
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公开(公告)号：WO2004034991A3
公开(公告)日：2004-08-19
申请号：PCT/US0332719
申请日：2003-10-16
Applicant: ISIS PHARMACEUTICALS INC , FREIER SUSAN M , DOBIE KENNETH W , BHANOT SANJAY
Inventor： FREIER SUSAN M , DOBIE KENNETH W , BHANOT SANJAY
CPC classification number: C07H21/04 , Y02P20/582
Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of fatty acid synthase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fatty acid synthase. Methods of using these compounds for modulation of fatty acid synthase expression and for treatment of diseases associated with expression of fatty acid synthase are provided.
Abstract translation: 提供反义化合物，组合物和方法用于调节脂肪酸合酶的表达。 该组合物包含靶向编码脂肪酸合酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节脂肪酸合酶表达和治疗与脂肪酸合酶表达有关的疾病的方法。
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10.发明申请ANTISENSE OLIGONUCLEOTIDES FOR MODIFYING EXPRESSION OF ACC1 AND ACC2 AND FOR CONTROLLING METABOLIC DISORDERS 审中-公开用于修饰ACC1和ACC2表达的抗体寡核苷酸和用于控制代谢异常的反义寡核苷酸
公开(公告)号：WO2006110775A3
公开(公告)日：2010-07-01
申请号：PCT/US2006013536
申请日：2006-04-10
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , MONIA BRETT P , GEISLER JOHN , MCKAY ROBERT , DOBIE KENNETH W
Inventor： BHANOT SANJAY , MONIA BRETT P , GEISLER JOHN , MCKAY ROBERT , DOBIE KENNETH W
IPC: C07H21/02 , A61K31/7088
CPC classification number: C12N15/1137 , A61K31/202 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of ACCl or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
Abstract translation: 本文公开了用于调节细胞，组织或动物中ACC1或ACC2或两者的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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