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公开(公告)号：WO2004011623A3
公开(公告)日：2005-04-21
申请号：PCT/US0323972
申请日：2003-07-31
Applicant: ISIS PHARMACEUTICALS INC , COWSERT LEX M , FREIER SUSAN M , DOBIE KENNETH W
Inventor： COWSERT LEX M , FREIER SUSAN M , DOBIE KENNETH W
CPC classification number: C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
Abstract: Antisense compounds, composition and methods are provided for modulating the expression of PTPRA. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPRA. Methods of using these compounds for modulation of PTPRA expression and for treatment of diseases associated with expression of PTPRA are provided.
Abstract translation: 提供反义化合物，组合物和方法用于调节PTPRA的表达。 组合物包含靶向编码PTPRA的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTPRA表达和治疗与PTPRA表达相关的疾病的方法。
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公开(公告)号：WO2004009024A3
公开(公告)日：2004-08-12
申请号：PCT/US0322651
申请日：2003-07-18
Applicant: ISIS PHARMACEUTICALS INC , COWSERT LEX M , FREIER SUSAN M , DOBIE KENNETH W
Inventor： COWSERT LEX M , FREIER SUSAN M , DOBIE KENNETH W
IPC: A61K38/00 , A61K48/00 , C12N15/113 , C07H21/04 , C12N15/00
CPC classification number: C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11013 , Y02P20/582 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of protein kinase C-iota. The compositions comprise oligonucleotides, targeted to nucleic acid encoding protein kinase C-iota. Methods of using these compounds for modulation of protein kinase C-iota expression and for diagnosis and treatment of disease associated with expression of protein kinase C-iota are provided.
Abstract translation: 提供化合物，组合物和方法用于调节蛋白激酶C-iota的表达。 组合物包含靶向编码蛋白激酶C-iota的核酸的寡核苷酸。 提供了使用这些化合物调节蛋白激酶C-iota表达以及用于诊断和治疗与蛋白激酶C-iota的表达相关的疾病的方法。
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公开(公告)号：WO2004071407A2
公开(公告)日：2004-08-26
申请号：PCT/US2004002003
申请日：2004-02-06
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , COWSERT LEX M , WYATT JACQUELINE R , FREIER SUSAN M , MONIA BRETT P , BUTLER MADELINE M , MCKAY ROBERT , DOBIE KENNETH W
Inventor： BHANOT SANJAY , COWSERT LEX M , WYATT JACQUELINE R , FREIER SUSAN M , MONIA BRETT P , BUTLER MADELINE M , MCKAY ROBERT , DOBIE KENNETH W
IPC: A61K20060101 , A61K38/00 , A61K48/00 , C12N5/02 , C12N15/113 , A61K
CPC classification number: C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
Abstract translation: 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：WO2004009018A3
公开(公告)日：2004-08-26
申请号：PCT/US0322422
申请日：2003-07-18
Applicant: ISIS PHARMACEUTICALS INC , COWSERT LEX M , DOBIE KENNETH W
Inventor： COWSERT LEX M , DOBIE KENNETH W
CPC classification number: C12N15/1138 , A61K38/00 , A61K48/00 , C07H21/04 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of PTPRM. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPRM. Methods of using these compounds for modulation of PTPRM expression and for treatment of diseases associated with expression of PTPRM are provided.
Abstract translation: 提供反义化合物，组合物和方法用于调节PTPRM的表达。 该组合物包含靶向编码PTPRM的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTPRM表达和治疗与PTPRM表达相关的疾病的方法。
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公开(公告)号：WO2005028633A3
公开(公告)日：2008-11-06
申请号：PCT/US2004030736
申请日：2004-09-17
Applicant: ISIS PHARMACEUTICALS INC , BAKER BRENDA F , BENNETT FRANK C , DOBIE KENNETH W , MYERS KATHLEEN , FINGER JOSHUA , COWSERT LEX M
Inventor： BAKER BRENDA F , BENNETT FRANK C , DOBIE KENNETH W , MYERS KATHLEEN , FINGER JOSHUA , COWSERT LEX M
IPC: C07H21/02 , A61K48/00 , C07H21/04 , C12N20060101
CPC classification number: C07H21/02 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/345
Abstract: Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.
Abstract translation: 提供化合物，组合物和方法用于调节RANKL的表达。 组合物包含针对编码RANKL的核酸的寡核苷酸。 提供了使用这些化合物调节RANKL表达和用于诊断和治疗与RANKL表达相关的疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2004054502A3
公开(公告)日：2005-06-30
申请号：PCT/US0337085
申请日：2003-12-11
Applicant: ISIS PHARMACEUTICALS INC , COWSERT LEX M , DOBIE KENNETH W
Inventor： COWSERT LEX M , DOBIE KENNETH W
IPC: A01N43/04 , A61K20060101 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/63 , C12P19/34 , C12Q1/68
CPC classification number: C07H21/04
Abstract: Compounds, compositions and methods are provided for modulating the expression of TEK. The compositions comprise oligonucleotides, targeted to nucleic acid encoding TEK. Methods of using these compounds for modulation of TEK expression and for diagnosis and treatment of disease associated with expression of TEK are provided.
Abstract translation: 提供化合物，组合物和方法用于调节TEK的表达。 组合物包含靶向编码TEK的核酸的寡核苷酸。 提供了使用这些化合物调节TEK表达和用于诊断和治疗与TEK表达相关的疾病的方法。
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公开(公告)号：WO2007137301A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069587
申请日：2007-05-23
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W , MURRAY SUSAN F
Inventor： BHANOT SANJAY , DOBIE KENNETH W , MURRAY SUSAN F
IPC: A61K48/00
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/322 , C12N2310/341 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions, and methods for modulating the expression of ChREBP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and conditions.
Abstract translation: 本文公开了用于调节细胞，组织或动物中ChREBP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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8.发明申请COMPOSITIONS AND THEIR USES DIRECTED TO THYMUS AND ACTIVATION-REGULATED CHEMOKINE (TARC) 审中-公开组合物及其与三氯乙烯和激活性调节化学药物（TARC）的用途及其用途
公开(公告)号：WO2006105204A3
公开(公告)日：2007-01-04
申请号：PCT/US2006011478
申请日：2006-03-28
Applicant: ISIS PHARMACEUTICALS INC , KARRAS JAMES G , DOBIE KENNETH W
Inventor： KARRAS JAMES G , DOBIE KENNETH W
CPC classification number: C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of TARC, airway hyperresponsiveness, and/or pulmonary inflammation.
Abstract translation: 本文公开了用于调节细胞，组织或动物中TARC表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与TARC表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：WO2004093783A3
公开(公告)日：2006-05-04
申请号：PCT/US2004010946
申请日：2004-04-15
Applicant: ISIS PHARMACEUTICALS INC , CROOKE ROSANNE M , GRAHAM MARK J , LEMONIDIS TARBET KRISTINA M , DOBIE KENNETH W
Inventor： CROOKE ROSANNE M , GRAHAM MARK J , LEMONIDIS TARBET KRISTINA M , DOBIE KENNETH W
IPC: C07H21/04 , A61K38/00 , C12N15/113
CPC classification number: C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
Abstract translation: 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：WO2005054518A3
公开(公告)日：2005-07-07
申请号：PCT/US2004041019
申请日：2004-12-06
Applicant: ISIS PHARMACEUTICALS INC , BENNETT FRANK C , BUTLER MADELINE M , DEAN NICHOLAS M , DOBIE KENNETH W , FINGER JOSHUA , JAIN RAVI , MCKAY ROBERT , MONIA BRETT P , MYERS KATHLEEN
Inventor： BENNETT FRANK C , BUTLER MADELINE M , DEAN NICHOLAS M , DOBIE KENNETH W , FINGER JOSHUA , JAIN RAVI , MCKAY ROBERT , MONIA BRETT P , MYERS KATHLEEN
CPC classification number: C07H21/04
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
Abstract translation: 本文公开了用于调节细胞，组织或动物中骨生长调节剂表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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