公开(公告)号：WO2016071863A1

公开(公告)日：2016-05-12

申请号：PCT/IB2015/058551

申请日：2015-11-05

申请人： ISTITUTO ORTOPEDICO RIZZOLI ,  UNIVERSITA' DI PISA

发明人： LISIGNOLI, Gina ,  GRASSI, Francesco ,  CALDERONE, Vincenzo ,  RAPPOSELLI, Simona

IPC分类号： C07C331/24 ,  A61K31/663 ,  C07F9/38

CPC分类号： A61K31/663 ,  C07C331/24 ,  C07C331/28 ,  C07F9/38 ,  C07F9/3873

摘要： The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ri is selected from an SCN- group or is an RCONH- group; in particular, where Ri = RCONH, R is selected from an aromatic benzene ring substituted with an SCN- group in the ortho, meta or para position, according to the following formula: SCN- or R is a C1 -C4 alkyl chain, substituted with an SCN- group; n can be equal to 0 or else 1. The invention also relates to the use of such compounds for the treatment of osteoporosis and in general of bone pathologies characterised by a progressive loss of bone mass, for example rheumatoid arthritis, hyperparathyroidism or bone tumour metastases

摘要翻译： 本发明涉及通式（I）的化合物及其药学上可接受的盐：（I）其中R 1选自SCN-基团或是RCONH-基团; 特别地，其中R 1 = RCONH，R选自在邻位，间位或对位被SCN-基团取代的芳香苯环，根据下式：SCN-或R是C1-C4烷基链，被取代 与SCN组; 本发明还涉及这些化合物用于治疗骨质疏松症的用途，并且一般涉及以逐渐丧失骨量为特征的骨病理学，例如类风湿性关节炎，甲状旁腺功能亢进或骨肿瘤转移