公开(公告)号：WO1992009300A1

公开(公告)日：1992-06-11

申请号：PCT/US1991008694

申请日：1991-11-20

Applicant: ITEREX PHARMACEUTICALS LTD. PARTNERSHIP

Inventor： ITEREX PHARMACEUTICALS LTD. PARTNERSHIP ,  HOUGHTEN, Richard, A. ,  CUERVO, Julio, Hernan ,  PINILLA, Clemencia ,  APPEL, Jon, R., Jr. ,  BLONDELLE, Silvie

IPC: A61K37/02

CPC classification number: C07K7/06 ,  B01J19/0046 ,  B01J2219/00297 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00725 ,  C07K1/047 ,  C40B40/10 ,  C40B60/14

Abstract: A process for the synthesis of a complex mixture pool of solid support-coupled monomeric repeating unit compounds such as amino acid derivatives is disclosed in which the mixture pool contains an equimolar representation of reacted monomeric repeating unit compounds coupled. Also disclosed is a process for the stepwise synthesis of a complex mixture of coupled or free, unsupported oligomers such as oligopeptides. A set of self-solubilizing, unsupported mixed oligopeptides having one or more predetermined amino acid residues at one or more of the same, predetermined positions in the oligopeptide chain in which the set contains equimolar amounts of a plurality of different amino acid residues, preferably at least six different residues, at one or more of the same predetermined positions of the oligopeptide chain is also disclosed, as are methods of making and using the same.

Abstract translation: 公开了一种用于合成固体支持偶联单体重复单元化合物如氨基酸衍生物的复合混合物池的方法，其中混合物池包含偶联反应的单体重复单元化合物的等摩尔表示。 还公开了逐步合成偶联或游离的，未负载的寡聚物如寡肽的复合混合物的方法。 在寡肽链中的一个或多个相同的预定位置上具有一个或多个预定氨基酸残基的一组自溶解的，未支撑的混合寡肽，其中该组含有等摩尔量的多个不同氨基酸残基，优选在 还公开了在寡肽链的一个或多个相同的预定位置处的至少六个不同的残基，以及制备和使用寡肽链的方法。