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    ANTIGEN BINDING REGIONS AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME
    1.
    发明申请
    ANTIGEN BINDING REGIONS AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：WO2019018402A2

    公开(公告)日：2019-01-24

    申请号：PCT/US2018/042495

    申请日：2018-07-17

    申请人： JANSSEN BIOTECH, INC.

    发明人： HUANG, Chichi ,  LEE, John ,  MOONEY, Jill ,  NASO, Michael

    IPC分类号： C07K16/18

    摘要： Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3 domain antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled FN3 domain antibodies or antigen-binding fragments may be used to engineer FN3 domain-targeting chimeric antigen receptors (CARs). Methods of making the FN3 domain antibodies, CARs, and engineered immune cells, and methods of using the engineered immune cells are applicable to treat diseases including cancer.

    IMMORTALIZED CAR-T CELLS GENETICALLY MODIFIED TO ELIMINATE T-CELL RECEPTOR AND BETA 2-MICROGLOBULIN EXPRESSION
    3.
    发明申请
    IMMORTALIZED CAR-T CELLS GENETICALLY MODIFIED TO ELIMINATE T-CELL RECEPTOR AND BETA 2-MICROGLOBULIN EXPRESSION 审中-公开

    公开(公告)号：WO2019118475A1

    公开(公告)日：2019-06-20

    申请号：PCT/US2018/064971

    申请日：2018-12-11

    申请人： JANSSEN BIOTECH, INC.

    发明人： LEE, John ,  MOONEY, Jill ,  NASO, Michael

    IPC分类号： C12N5/0783 ,  C07K16/28 ,  C07K14/725 ,  C07K14/74 ,  A61K35/17 ,  A61P35/00

    摘要： The present invention pertains to engineered immortalized T-cell lines, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered immortalized T-cell lines of the invention are characterized in that the expression of endogenous T-cell receptors (TCRs) and beta 2-microglobulin (B2M) is inhibited, e.g., by using an endonuclease able to selectively inactivate the TCR and B2M genes in order to render the immortalized T-cells non-alloreactive. In addition, expression of immunosuppressive polypeptide can be performed on those engineered immortalized T-cells in order to prolong the survival of these T-cells in host organisms. Such engineered immortalized T-cells are particularly suitable for allogeneic transplantations, especially because it reduces both the risk of rejection by the host's immune system and the risk of developing graft versus host disease. The invention opens the way to standard and affordable adoptive immunotherapy strategies using immortalized T-cells for treating cancer, infections and auto-immune diseases.

    ANTIGEN BINDING REGIONS AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME
    5.
    发明申请
    ANTIGEN BINDING REGIONS AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：WO2019018402A3

    公开(公告)日：2019-01-24

    申请号：PCT/US2018/042495

    申请日：2018-07-17

    申请人： JANSSEN BIOTECH, INC.

    发明人： HUANG, Chichi ,  LEE, John ,  MOONEY, Jill ,  NASO, Michael

    IPC分类号： A61K39/00 ,  C07K16/28

    摘要： Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3 domain antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled FN3 domain antibodies or antigen-binding fragments may be used to engineer FN3 domain-targeting chimeric antigen receptors (CARs). Methods of making the FN3 domain antibodies, CARs, and engineered immune cells, and methods of using the engineered immune cells are applicable to treat diseases including cancer.

    CHIMERIC ANTIGEN RECEPTORS COMPRISING BCMA-SPECIFIC FIBRONECTIN TYPE III DOMAINS AND USES THEREOF
    6.
    发明申请
    CHIMERIC ANTIGEN RECEPTORS COMPRISING BCMA-SPECIFIC FIBRONECTIN TYPE III DOMAINS AND USES THEREOF 审中-公开
    含有BCMA特异性纤连蛋白III型结构域的嵌合体抗原受体及其用途

    公开(公告)号：WO2018052828A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/050888

    申请日：2017-09-11

    申请人： JANSSEN BIOTECH, INC.

    发明人： CHIN, Chen Ni ,  LEE, John ,  MCCABE, Timothy ,  MOONEY, Jill ,  NASO, Michael ,  STROHL, William

    IPC分类号： A61K39/00 ,  C07K16/28

    摘要： BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.

    摘要翻译： 描述了BCMA特异性纤连蛋白III型（FN3）结构域，包含FN3结构域的BCMA靶向嵌合抗原受体（CAR）和表达CAR的工程化BCMA靶向免疫细胞。 还描述了编码FN3结构域和CAR的核酸和表达载体，含有载体的重组细胞，以及包含工程化免疫细胞的组合物。 还描述了制造FN3结构域，CAR和工程改造的免疫细胞的方法，以及使用改造的免疫细胞治疗包括癌症的疾病的方法。