公开(公告)号：WO2019118046A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/052829

申请日：2018-09-26

申请人： L'OREAL ,  YALE UNIVERSITY

发明人： GEORGE, Kelly, Marie ,  PAN, Zhi ,  MARROT, Laurent ,  WANG, Miao ,  BRASH, Douglas, Edgar ,  PREMI, Sanjay ,  GONCALVES, Leticia, C.P.

IPC分类号： A61Q17/04

CPC分类号： A61K36/704 ,  A61K8/31 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/40 ,  A61K8/44 ,  A61K8/4926 ,  A61K8/498 ,  A61K8/9717 ,  A61K8/9789 ,  A61K31/01 ,  A61K31/015 ,  A61K31/12 ,  A61K31/19 ,  A61K31/192 ,  A61K31/353 ,  A61K31/366 ,  A61K31/44 ,  A61K36/04 ,  A61K36/287 ,  A61K36/355 ,  A61K36/48 ,  A61K36/539 ,  A61K47/12 ,  A61K47/24 ,  A61Q19/004

摘要： A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof. The dCPD quencher may be administered to the subject in the absence of UV radiation.