公开(公告)号：WO2014090875A1

公开(公告)日：2014-06-19

申请号：PCT/EP2013/076226

申请日：2013-12-11

Applicant: LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH

Inventor： SINGH, Mahavir ,  WANAS, Hanaa ,  OEHLMANN, Wulf ,  VILAPLANA, Cristina

IPC: A61K31/133 ,  A61K31/366 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K31/133 ,  A61K31/366 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition comprising a combination of ethambutol with at least one additional anti-bacterial agent, in particular, anti-mycobacterial agent for use in the treatment of bacterial infection, in particular, mycobacterial infection.

Abstract translation: 本发明涉及包含乙胺丁醇与至少一种另外的抗菌剂的组合的药物组合物，特别是用于治疗细菌感染，特别是分枝杆菌感染的抗分枝杆菌剂。

公开(公告)号：WO2014044838A1

公开(公告)日：2014-03-27

申请号：PCT/EP2013/069671

申请日：2013-09-23

Applicant: LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH

Inventor： SINGH, Mahavir ,  BAUMANN, Ralf. ,  KÄMPFER, Susanne ,  SPALLEK, Ralf ,  OEHLMANN, Wulf

IPC: G01N33/569

CPC classification number: C12Q1/28 ,  G01N2333/35 ,  G01N2333/908

Abstract: In the first aspect, the present invention relates to mycobacterial thiolperoxidase for use in diagnosing or determining tuberculosis infection in an individual. In a further aspect, methods are provided for diagnosing or determining the status of tuberculosis infection in individuals infected or suspected to be afflicted with tuberculosis infection comprising the step of determining the level or amount of antibodies against mycobacterial thioperoxidase in a sample of an individual. Moreover, methods are provided for the stratification of the treatment regimen of said individual as well as for monitoring the change from latent to active status of tuberculosis infection. Moreover, the present invention provides kits for use in diagnosing or detecting tuberculosis infection as well as the status of the same based on the level or amount of mycobacterial thiolperoxidase.

Abstract translation: 在第一方面，本发明涉及用于诊断或确定个体中结核感染的分枝杆菌硫羟过氧化物酶。 在另一方面，提供了用于诊断或确定感染或怀疑患有结核病感染的个体中的结核病感染状况的方法，包括确定个体样品中针对分枝杆菌硫代过氧化物酶的抗体的水平或量的步骤。 此外，提供了用于分层所述个体的治疗方案以及用于监测结核病感染的潜伏状态到活动状态的方法。 此外，本发明提供了用于诊断或检测结核病感染的试剂盒以及基于分枝杆菌硫羟过氧化物酶的水平或量的其状态。