公开(公告)号：WO2014053245A1

公开(公告)日：2014-04-10

申请号：PCT/EP2013/002978

申请日：2013-10-02

Applicant: LIPOCALYX GMBH

Inventor： PANZNER, Steffen ,  REINSCH, Christian ,  WENDISCH, Volkmar ,  DREHER, Christina

IPC: A61K47/48

CPC classification number: C12N15/113 ,  A61K47/543 ,  A61K47/59 ,  A61K47/645 ,  C08G73/0206 ,  C08L79/02 ,  C08L2203/02 ,  C12N15/85 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2800/107

Abstract: The invention provides hydroxylated polyamine derivatives, their use for the transfection of polyanions into cells, and a method of transfecting cells with a polyanion, comprising mixing said polyanion with said hydroxylated polyamine derivative in a buffer and treating said cells with the mixture obtained in the previous step.

Abstract translation: 本发明提供羟基化多胺衍生物，它们用于将聚阴离子转染入细胞的用途，以及用聚阴离子转染细胞的方法，包括将所述聚阴离子与所述羟基化多胺衍生物混合在缓冲液中，并用前面得到的混合物处理所述细胞 步。

公开(公告)号：WO2014056590A1

公开(公告)日：2014-04-17

申请号：PCT/EP2013/002979

申请日：2013-10-02

Applicant: LIPOCALYX GMBH

Inventor： PANZNER, Steffen ,  REINSCH, Christian ,  WENDISCH, Volkmar ,  DREHER, Christina

IPC: A61K47/48

CPC classification number: C12N15/64 ,  A61K47/542 ,  A61K47/543 ,  A61K47/59 ,  A61K47/645 ,  C08F8/14 ,  C08F8/18 ,  C08G73/0206 ,  C08G81/00 ,  C08K5/205 ,  C08L39/00 ,  C08L39/02 ,  C08L79/02 ,  C08L2203/02 ,  C12N15/1137 ,  C12N15/85 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2800/107

Abstract: The invention provides polyamine derivatives, a use of the polyamine derivatives for the transfection of polyanions into cells, and a method of transfecting cells with a polyanion, comprising mixing said polyanion with a polyamine derivative e.g. in a buffer and treating said cells with the mixture obtained in the previous step.

Abstract translation: 本发明提供多胺衍生物，多胺衍生物用于将聚阴离子转染到细胞中的用途，以及用聚阴离子转染细胞的方法，包括将所述聚阴离子与多胺衍生物 在缓冲液中并用前一步骤获得的混合物处理所述细胞。