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    METHODS AND POLYPEPTIDES FOR MODULATION OF IMMUNORESPONSE
    4.
    发明申请
    METHODS AND POLYPEPTIDES FOR MODULATION OF IMMUNORESPONSE 审中-公开
    免疫调节的方法和多肽

    公开(公告)号：WO2016197975A1

    公开(公告)日：2016-12-15

    申请号：PCT/CN2016/085452

    申请日：2016-06-12

    申请人： LU, Yen-Ta

    发明人： LU, Yen-Ta ,  CHANG, Chia-Ming ,  WEI, Tsai-Yin

    IPC分类号： A61K38/02 ,  C07K14/705 ,  C07K14/47 ,  A61P37/06

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  A61K38/1774 ,  A61K45/06 ,  A61K47/59 ,  A61K47/643 ,  A61P37/06 ,  C07K14/705 ,  C07K2319/70

    摘要： The disclosure found that TLT-1 directly binds to immune cells and triggers cells to express immunosuppressive phenotypes; i.e., down-regulation of HLA-DR and up-regulation of PD-L1. The induction of PD-L1 and reduction of HLA-DR by TLT-1 or TLT-1-derived polypeptides can therefore be useful in treating diseases associated with immune hyper-reactivity, such as autoimmune diseases, hypersensitivity reactions, transplantation rejections and graft versus host disorders.

    摘要翻译： 本发明揭示TLT-1直接结合免疫细胞并触发细胞表达免疫抑制表型; 即HLA-DR的下调和PD-L1的上调。 因此，TLT-1或TLT-1衍生的多肽的PD-L1诱导和HLA-DR的减少因此可用于治疗与免疫高反应性相关的疾病，例如自身免疫性疾病，超敏反应，移植排斥和移植物抗体 宿主障碍。

    DISULFIDE POLYMERS AND METHODS OF USE
    6.
    发明申请
    DISULFIDE POLYMERS AND METHODS OF USE 审中-公开
    分散聚合物及其使用方法

    公开(公告)号：WO2016040814A3

    公开(公告)日：2016-05-06

    申请号：PCT/US2015049702

    申请日：2015-09-11

    申请人： BRIGHAM & WOMENS HOSPITAL

    发明人： FAROKHZAD OMID C ,  WU JUN ,  ZHAO LILI

    IPC分类号： A61K31/795

    CPC分类号： C08G75/14 ,  A61K9/5031 ,  A61K31/704 ,  A61K47/59

    摘要： Provided herein are disulfide polymers, methods of their preparation, compositions, and methods of using the same. For example, provided herein are polymers having at least one repeating unit according to Formula (I):or Formula (II): and nanoparticles and compositions including the same. The polymers and compositions provided herein may be used, for example, in the encapsulation of drugs for a slow release drug administration in the treatment or imaging of diseases.

    摘要翻译： 本文提供了二硫化物聚合物，其制备方法，组合物及其使用方法。 例如，本文提供的是具有至少一个根据式（I）的重复单元或式（II）的聚合物：和纳米颗粒和包含它们的组合物。 本文提供的聚合物和组合物可用于例如用于缓释药物给药的药物在疾病的治疗或成像中的包封。

    HELICAL POLYCARBODIIMIDE POLYMERS AND ASSOCIATED IMAGING, DIAGNOSTIC, AND THERAPEUTIC METHODS
    7.
    发明申请
    HELICAL POLYCARBODIIMIDE POLYMERS AND ASSOCIATED IMAGING, DIAGNOSTIC, AND THERAPEUTIC METHODS 审中-公开
    螺旋聚合物聚合物和相关成像，诊断和治疗方法

    公开(公告)号：WO2016028636A1

    公开(公告)日：2016-02-25

    申请号：PCT/US2015/045278

    申请日：2015-08-14

    申请人： MEMORIAL SLOAN KETTERING CANCER CENTER

    发明人： HELLER, Daniel A. ,  BUDHATHOKI-UPRETY, Januka

    IPC分类号： D01F11/14

    CPC分类号： A61K51/065 ,  A61K47/48192 ,  A61K47/48876 ,  A61K47/59 ,  A61K47/6927 ,  A61K51/1251 ,  C01B31/0253 ,  C01B32/168 ,  G01N33/542 ,  G01N33/587

    摘要： Described herein are suspensions of helical polycarbodiimide polymers that 'cloak' nanotubes, thereby effecting control over nanotube emission, providing a new mechanism of environmental responsivity, and enabling precise control over sub-cellular localization. The helical polycarbodiimide polymers described herein are water soluble, easily modifiable, and have unique architectures that facilitate their application in radiopharmaceutical delivery and imaging methods, in therapeutics and therapeutic delivery methods, and their use as sensors - both in conjunction with carbon nanotubes, and without nanotubes.

    摘要翻译： 本文描述了螺旋聚碳二亚胺聚合物的悬浮液，其是“覆盖”纳米管，从而实现对纳米管发射的控制，提供环境响应性的新机制，并且能够精确控制亚细胞定位。 本文所述的螺旋聚碳二亚胺聚合物是水溶性的，易于修饰的，并且具有独特的结构，其有助于其在放射性药物递送和成像方法，治疗和治疗递送方法中的应用，以及它们作为传感器的使用 - 既与碳纳米管结合，又不与碳纳米管结合使用 纳米管。

    POLYOXAZOLINE ANTIBODY DRUG CONJUGATES
    8.
    发明申请
    POLYOXAZOLINE ANTIBODY DRUG CONJUGATES 审中-公开
    聚羧酰胺抗体药物联合

    公开(公告)号：WO2016019340A1

    公开(公告)日：2016-02-04

    申请号：PCT/US2015/043297

    申请日：2015-07-31

    申请人： SERINA THERAPEUTICS, INC.

    发明人： MOREADITH, Randall ,  BENTLEY, Michael ,  FANG, Zhihao ,  VIEGAS, Tacey

    IPC分类号： C08G73/06 ,  C08G69/00 ,  C08G75/02

    CPC分类号： A61K47/48384 ,  A61K47/557 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6883 ,  A61K47/6889

    摘要： In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.

    摘要翻译： 在本公开内容中，描述了聚合物缀合物，包括聚合物 - 抗体 - 药物偶联物（聚合物ADC），以及这些缀合物用于治疗人类疾病的用途。 聚合物缀合物可以含有大量的聚合物结合剂，因此有效地增加了抗体的药物抗体比例（DAR），超过目前可获得的技术。 当将低密度抗体的抗体用作靶抗体时，这可能是特别重要的。 所描述的聚合物-ADC相对于传统的ADC具有改善的药代动力学和溶解度。 试剂和聚合物之间的接头可以被定制以提供在所需位置和肿瘤内所需条件下释放毒素。 本公开的聚合物-ADC的另外的特征是纯化部分可以连接到聚合物主链以提供聚合物-ADC的简便性。

    METHODS AND PRODUCTS FROM THE REACTION OF TETRAZINES WITH NUCLEIC ACID POLYMERS BEARING ETHENYL AROMATIC GROUPS
    9.
    发明申请
    METHODS AND PRODUCTS FROM THE REACTION OF TETRAZINES WITH NUCLEIC ACID POLYMERS BEARING ETHENYL AROMATIC GROUPS 审中-公开
    四乙基胺与含有亚甲基芳族基团的核酸聚合物反应的方法和产物

    公开(公告)号：WO2015197655A1

    公开(公告)日：2015-12-30

    申请号：PCT/EP2015/064165

    申请日：2015-06-23

    申请人： UNIVERSITÄT ZÜRICH

    发明人： LUEDTKE, Nathan ,  RIEDER, Ulrike

    IPC分类号： A61K49/00 ,  C07D487/04 ,  C12Q1/68

    CPC分类号： A61K49/0054 ,  A61K47/59 ,  A61K49/0041 ,  C07D405/14 ,  C07D487/04

    摘要： This invention pertains to the preparation of modified nucleic acids by means of enzymatic synthesis and chemical modification of nucleic acids bearing ethenyl aromatic groups with tetrazines. The invention is also directed to the products of the process; comprising nucleosides/nucleotides and nucleic acids containing one or more dihydropyridazine and/or pyridazine units located at the 5-position of pyrimidines and/or the 7-position of 7- deazapurine residues.

    摘要翻译： 本发明涉及通过酶促合成和用四嗪进行乙烯基芳族基团的核酸的化学修饰来制备修饰的核酸。 本发明还涉及该方法的产物; 包含核苷/核苷酸和含有一个或多个二氢哒嗪和/或哒嗪单元的核酸，位于嘧啶的5-位和/或7-脱氮嘌呤残基的7-位。