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    METHOD AND APPARATUS FOR DETERMINING DIFFUSION PROPERTIES OF A SAMPLE
    1.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING DIFFUSION PROPERTIES OF A SAMPLE 审中-公开
    确定样品扩散性质的方法和设备

    公开(公告)号：WO2017144622A1

    公开(公告)日：2017-08-31

    申请号：PCT/EP2017/054250

    申请日：2017-02-23

    Applicant: MALVERN INSTRUMENTS LIMITED ,  PARAYTEC LIMITED

    Inventor： LATUNDE-DADA, Seyi ,  LESZCZYSZYN, Oksana ,  GOODALL, David

    IPC: G01N15/06 ,  G01N13/00

    CPC classification number: G01N13/00 ,  G01N15/0205 ,  G01N2013/003 ,  G01N2015/0038 ,  G01N2015/0277

    Abstract: A method (101) of using an apparatus comprising a processor to determine a diffusion coefficient ( D ) of a solute in a solution flowing in a capillary, comprising: obtaining a first signal (501) comprising a plurality of measurements of solute concentration measured at a first measurement location corresponding with a first mean measurement time that is before a full dispersion condition is met;obtaining a second signal (502) comprising a plurality of measurements of solute concentration measured at a second measurement location corresponding with a second mean measurement time that is after the first mean measurement time and before a full dispersion condition is met; determining a first front amplitude A 1 of a solute front from the first signal (501); determining a second front amplitude A 2 of a solute front from the second signal (502), the second front amplitude corresponding to the arrival of fast moving molecules travelling at or near a central streamline at the second measurement location; calculating: an actual front height ratio A 2 /A 1 of the second front amplitude A 2 to the first front amplitude A 1 ; a convection front height ratio h expected for a pure convection regime; and a proportion f of the solute that dispersed between the first mean measurement time and the second mean measurement time, the proportion f calculated using the actual front height ratio A 2 /A 1 and the convection front height ratio h ;deriving a value of the diffusion coefficient ( D ) of the solute from a relationship between the proportion f and the diffusion coefficient, the relationship corresponding with the measurement conditions of the first and second signal.

    Abstract translation: 一种使用包括处理器的设备来确定在毛细管中流动的溶液中的溶质的扩散系数（D）的方法（101），包括：获得 第一信号（501），其包括在与满足完全扩散条件之前的第一平均测量时间对应的第一测量位置处测量的溶质浓度的多个测量结果;获得第二信号（502），该第二信号包括多个溶质 在与在第一平均测量时间之后且满足完全散布条件之前的第二平均测量时间对应的第二测量位置处测量的浓度; 根据第一信号（501）确定溶质前沿的第一前振幅A 1; 从第二信号（502）确定溶质前沿的第二前振幅A 2，第二前振幅对应于在第二测量位置处在中心流线处或附近行进的快速移动分子的到达 ; 计算：第二前振幅A 2到第一前振幅A 1的实际前部高度比A 2 / A 1 1 ; 纯对流状态下预期的对流前高度比h; 以及分散在第一平均测量时间和第二平均测量时间之间的溶质的比例f，使用实际正面高度比率A计算出的比例f f， 2 / A 1和对流正面高度比率h;推导出溶质的扩散系数（D）的值 根据比例f和扩散系数之间的关系，确定与第一和第二信号的测量条件相对应的关系。

    VISCOSITY MEASUREMENT APPARATUS AND METHOD
    2.
    发明申请
    VISCOSITY MEASUREMENT APPARATUS AND METHOD 审中-公开
    粘度测量装置和方法

    公开(公告)号：WO2012046054A1

    公开(公告)日：2012-04-12

    申请号：PCT/GB2011/051903

    申请日：2011-10-05

    Applicant: PARAYTEC LIMITED ,  GOODALL, David

    Inventor： GOODALL, David

    IPC: G01N11/04

    CPC classification number: G01N11/06 ,  G01N11/04 ,  G01N21/33

    Abstract: A method and apparatus for measuring the viscosity of a sample solution. A capillary (2) having first and second spaced apart detection windows (W1,W2) is filled with a carrier solution. A plug (4) or a continuous volume (4) of a sample solution is injected into the first end of the capillary (2) and pumped through the capillary (2) at a first pump pressure passing through the first and second detection windows (W1,W2). At least part of each detection window (W1,W2) is illuminated with a light source. Light from the light source passing through the carrier solution or the sample solution at each detector window (W1,W2) is detected using an array detector (6) comprising a two dimensional array of detector locations which generates an array detector output signal indicative of the profile of light absorbance of the sample solution plug (4) or flow front (4) passing through each detection window (W1,W2). From this the time difference between the time of detection of the sample solution plug (4) or flow front (4) at each detection window (W1,W2) is determined allowing the specific viscosity η sp of the sample solution to be calculated taking into account a known time difference between the time of detection at each detection window (W1,W2) for a plug (4) or flow front (4) of a reference sample solution whose viscosity is approximately equal to the viscosity of the carrier solution when pumped at the first pump pressure.

    Abstract translation: 用于测量样品溶液的粘度的方法和装置。 具有第一和第二间隔开的检测窗口（W1，W2）的毛细管（2）用载体溶液填充。 将样品溶液的塞子（4）或连续体积（4）注入到毛细管（2）的第一端中，并以通过第一和第二检测窗口的第一泵压力泵送通过毛细管（2） W1，W2）。 每个检测窗口（W1，W2）的至少一部分被光源照射。 使用包括检测器位置的二维阵列的阵列检测器（6）来检测来自在每个检测器窗口（W1，W2）处通过载体溶液或样品溶液的光源的光，该阵列检测器产生阵列检测器输出信号， 通过每个检测窗口（W1，W2）的样品溶液塞（4）或流动前（4）的吸光度曲线。 由此，确定在每个检测窗口（W1，W2）处的样品溶液塞（4）或流动前（4）的检测时间之间的时间差，使得可以计算样品溶液的比粘度Δsp 考虑了在泵送时粘度近似等于载体溶液的粘度的参考样品溶液的塞子（4）或前端（4）的每个检测窗口（W1，W2）处的检测时间之间的已知时间差 在第一个泵压力。

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