公开(公告)号：WO2018005687A1

公开(公告)日：2018-01-04

申请号：PCT/US2017/039819

申请日：2017-06-28

Applicant: MANTA INSTRUMENTS, INC.

Inventor： TATARKIEWICZ, Jan, J.

IPC: G01J3/42 ,  G01N15/00 ,  G01N15/02 ,  G01N31/00

Abstract: A method for calibrating dark field microcopy setup is disclosed. The method includes preparing a plurality of particle samples, each with a known concentration and particle size, the plurality having more than one particle size and, optionally, more than one refractive index and more than one diluent. For each sample in the plurality, the sample is measured in the setup and the scattered light intensity and number of particles is measured. From this data, a relationship between the scattered light intensity, particle size and calibrated investigated volume can be determined. The calibrated investigated volume is used to obtain the proper particle size distribution in a given diluent.

Abstract translation: 公开了一种用于校准暗视场显微镜设置的方法。 该方法包括制备多个颗粒样品，每个颗粒样品具有已知的浓度和颗粒尺寸，多个颗粒具有多于一个的颗粒尺寸，并且可选地具有多于一个的折射率和多于一个的稀释剂。 对于多个样本中的每个样本，在设置中测量样本并且测量散射光强度和粒子数量。 根据这些数据，可以确定散射光强度，粒度和标定的调查体积之间的关系。 校准的调查体积用于在给定的稀释剂中获得适当的粒度分布。

公开(公告)号：WO2017004021A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/039790

申请日：2016-06-28

Applicant: MANTA INSTRUMENTS, INC.

Inventor： TATARKIEWICZ, Jan, J. ,  COOPER, Rick

IPC: G01N21/03

CPC classification number: G01N21/03 ,  G01N15/0211 ,  G01N2015/0038 ,  G01N2015/0053 ,  G01N2021/0307

Abstract: A special purpose cuvette assembly with features that create a small, restricted volume to minimize bulk movements of liquid and that minimize backscattering of light. The special-purpose cuvette assembly enables recording of Brownian movements of nanoparticles in a liquid when it is placed in a suitable optical device comprising a light sheet and an optical microscope attached to a video camera that is oriented perpendicular to the light-sheet plane.

Abstract translation: 具有特征的专用比色皿组件，其具有小的限制体积，以最小化液体的体积运动并且使光的后向散射最小化。 专用比色皿组件可将纳米颗粒的布朗运动记录在液体中，以便将其放置在适合的光学装置中，该光学装置包括照明装置和附接到垂直于光平面的摄像机的光学显微镜。

公开(公告)号：WO2017066487A8

公开(公告)日：2017-04-20

申请号：PCT/US2016/056909

申请日：2016-10-13

Applicant: MANTA INSTRUMENTS, INC.

Inventor： TATARKIEWICZ, Jan, J. ,  KARR, Monette

IPC: G01N15/02

Abstract: A system for determining the growth/dissolution rate of colloidal particles is disclosed and includes multiple light sources and multiple sensors. A light source is constructed to emit a beam of electromagnetic radiation at a specimen chamber that holds the colloidal particles. The chamber allows a portion of the combined beam to scatter perpendicularly or at some other angle to the combined beam. The scattered portion of the beam is directed to a sensor that detects electromagnetic radiation. The sensor is connected to processor that activates the light source and obtains an image from the sensor. Multiple images are taken at a time interval and for each image taken, and a total image intensity level is calculated and normalized. A formula is then calculated that fits the normalized values over time and a slope is determined from the formula.