公开(公告)号：WO2016057855A8

公开(公告)日：2017-04-20

申请号：PCT/US2015054796

申请日：2015-10-08

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： GROSSMAN NIR ,  BONO DAVID ,  BOYDEN EDWARD

IPC: A61N1/36

CPC classification number: A61N1/36017 ,  A61N1/0529 ,  A61N1/36014 ,  A61N1/36125 ,  A61N1/36146 ,  A61N1/36185

Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

Abstract translation: 在本发明的说明性实施中，干涉刺激精确地指向脑中的任意区域。 目标区域不限于电极正下方的区域，但可以是任何浅表，中等深度或深度的大脑结构。 通过定位最大包络振幅的区域以使其位于目标组织处来实现靶向。 通过使至少一个电流通道反相，即，至少一个电流通道的电极对在两个电极之间具有基本上等于180度的相位差，电流通道之间的泄漏大大减少。 成对的刺激电极并排放置，而不是以传统的十字形图案，因此只产生一个最大包络振幅的区域。 通常，电流源用于驱动干扰电流。