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    NEUROSTIMULATION TARGETING BASED ON PULSE PARAMETERS
    1.
    发明申请
    NEUROSTIMULATION TARGETING BASED ON PULSE PARAMETERS 审中-公开
    基于脉冲参数的神经调节目标定位

    公开(公告)号：WO2017139602A1

    公开(公告)日：2017-08-17

    申请号：PCT/US2017/017407

    申请日：2017-02-10

    Applicant: VERILY LIFE SCIENCES, LLC

    Inventor： RAKHYANI, Anil, Kumar, Ram ,  O'DRISCOLL, Stephen ,  CONG, Peng

    IPC: A61N1/372 ,  A61N1/36

    CPC classification number: A61N1/37205 ,  A61N1/3605 ,  A61N1/36135 ,  A61N1/36146

    Abstract: A method and system for stimulating a function of a limb or an organ by neurostimulation. The method may include identifying a target location for neurostimulation by a micro particle having an electrode that transmits electrical pulses, wherein the target location is associated with control of the function. The method may further include selectively stimulating the target location by transmitting one or more electrical pulses defined by a set of parameters, to which the target location has a greater sensitivity. The system may include a micro particle having an electrode that transmits electrical pulses and a central controller that wirelessly powers and communicates with the micro particle and selectively stimulates a target location by instructing the micro particle to transmit one or more electrical pulses from the electrode defined by a set of parameters. In some implementations, the target location has a greater sensitivity to the set of parameters.

    Abstract translation: 通过神经刺激来刺激肢体或器官的功能的方法和系统。 该方法可包括通过具有传输电脉冲的电极的微颗粒识别用于神经刺激的目标位置，其中目标位置与功能的控制相关联。 该方法可以进一步包括通过传输由一组参数限定的一个或多个电脉冲来选择性地刺激目标位置，目标位置具有较高的灵敏度。 该系统可以包括具有传输电脉冲的电极的微颗粒和无线地供电并与微颗粒通信的中央控制器，并且通过指示微​​颗粒传输来自电极的一个或多个电脉冲来选择性地刺激目标位置，该电极由 一组参数。 在一些实现中，目标位置对参数集具有更高的敏感度。

    METHODS AND APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE
    2.
    发明申请
    METHODS AND APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE 审中-公开
    用于刺激生物组织的方法和设备

    公开(公告)号：WO2016057855A8

    公开(公告)日：2017-04-20

    申请号：PCT/US2015054796

    申请日：2015-10-08

    Applicant: MASSACHUSETTS INST TECHNOLOGY

    Inventor： GROSSMAN NIR ,  BONO DAVID ,  BOYDEN EDWARD

    IPC: A61N1/36

    CPC classification number: A61N1/36017 ,  A61N1/0529 ,  A61N1/36014 ,  A61N1/36125 ,  A61N1/36146 ,  A61N1/36185

    Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

    Abstract translation: 在本发明的说明性实施中，干涉刺激精确地指向脑中的任意区域。 目标区域不限于电极正下方的区域，但可以是任何浅表，中等深度或深度的大脑结构。 通过定位最大包络振幅的区域以使其位于目标组织处来实现靶向。 通过使至少一个电流通道反相，即，至少一个电流通道的电极对在两个电极之间具有基本上等于180度的相位差，电流通道之间的泄漏大大减少。 成对的刺激电极并排放置，而不是以传统的十字形图案，因此只产生一个最大包络振幅的区域。 通常，电流源用于驱动干扰电流。

    AN IMPLANTABLE NEURO-STIMULATION DEVICE
    5.
    发明申请
    AN IMPLANTABLE NEURO-STIMULATION DEVICE 审中-公开
    可植入神经刺激装置

    公开(公告)号：WO2016168485A1

    公开(公告)日：2016-10-20

    申请号：PCT/US2016/027570

    申请日：2016-04-14

    Applicant: ROBINSON, David ,  MANTES, Ernest

    Inventor： ROBINSON, David ,  MANTES, Ernest

    IPC: A61N1/05 ,  A61L31/00 ,  A61L31/14

    CPC classification number: A61N1/36071 ,  A61N1/0504 ,  A61N1/0526 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36057 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36128 ,  A61N1/36139 ,  A61N1/36146 ,  A61N1/3615 ,  A61N1/36178

    Abstract: An implantable electrical stimulation device includes an electrically conductive electrode configured for coupling with a pulse generator device and transmitting an electrical signal configured to generate a desirable electric field around a target tissue, and a porous substrate constructed of a bio-compatible and bio-survivable material having a structure that mimics extracellular matrix embedding and supporting the electrically conductive electrode. The implantable device further includes a pulse generator also embedded, enmeshed, and supported within the porous substrate.

    Abstract translation: 可植入电刺激装置包括导电电极，所述导电电极被配置为与脉冲发生器装置耦合并且传输被配置为在靶组织周围产生期望电场的电信号，以及由生物相容性和生物可存活材料构成的多孔基底 具有模拟细胞外基质嵌入并支撑导电电极的结构。 该可植入装置还包括一个脉冲发生器，它还嵌入，嵌入并支撑在多孔基底内。

    PATIENT REMOTE AND ASSOCIATED METHODS OF USE WITH A NERVE STIMULATION SYSTEM
    6.
    发明申请
    PATIENT REMOTE AND ASSOCIATED METHODS OF USE WITH A NERVE STIMULATION SYSTEM 审中-公开
    患者远程和相关的使用神经刺激系统的方法

    公开(公告)号：WO2016112398A1

    公开(公告)日：2016-07-14

    申请号：PCT/US2016/012918

    申请日：2016-01-11

    Applicant: AXONICS MODULATION TECHNOLOGIES, INC. ,  SCHROEDER, Dennis ,  SCHMID, Eric

    Inventor： SCHROEDER, Dennis ,  SCHMID, Eric ,  JIANG, Guangqiang ,  WOOCK, John

    IPC: A61N1/05 ,  A61N1/08 ,  A61N1/36

    CPC classification number: A61N1/37247 ,  A61N1/36057 ,  A61N1/36128 ,  A61N1/36132 ,  A61N1/36142 ,  A61N1/36146 ,  A61N1/37211 ,  A61N1/37235 ,  A61N1/37241

    Abstract: A neurostimulation system having an external or an implantable pulse generator programmed to innervate a specific nerve or group of nerves in a patient through an electrode as a mode of treatment, having a patient remote that wirelessly communicates with the pulse generator to increase stimulation, decrease stimulation, and provide indications to a patient regarding the status of the neurostimulation system. The patient remote can allow for adjustment of stimulation power within a clinically effective range and for turning on and turning off the pulse generator. The patient remote and neurostimulation system can also store a stimulation level when the pulse generator is turned off and automatically restore the pulse generator to the stored stimulation level when the pulse generator is turned on.

    Abstract translation: 具有外部或可植入脉冲发生器的神经刺激系统，该外部或可植入脉冲发生器被编程为通过电极作为治疗方式通过电极来支配患者中的特定神经或神经组，患者远程与脉冲发生器无线通信以增加刺激，减少刺激 并且向患者提供关于神经刺激系统的状态的指示。 患者远程可以允许在临床有效范围内调整刺激功率，并且用于打开和关闭脉冲发生器。 患者远程和神经刺激系统还可以在脉冲发生器关闭时存储刺激水平，并且当脉冲发生器接通时，将脉冲发生器自动恢复到存储的刺激水平。

    IMPLANTABLE STIMULATOR DEVICE HAVING SMALL DC-BLOCKING CAPACITORS
    7.
    发明申请
    IMPLANTABLE STIMULATOR DEVICE HAVING SMALL DC-BLOCKING CAPACITORS 审中-公开
    具有小直流阻塞电容器的可植入刺激装置

    公开(公告)号：WO2016081095A1

    公开(公告)日：2016-05-26

    申请号：PCT/US2015/055151

    申请日：2015-10-12

    Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

    Inventor： MARNFELDT, Goran, N.

    IPC: A61N1/36

    CPC classification number: A61N1/36125 ,  A61N1/3605 ,  A61N1/36128 ,  A61N1/36142 ,  A61N1/36146

    Abstract: Improved circuitry for an Implantable Pulse Generator (IPG) is disclosed that allows much smaller-value DC-blocking capacitors to be used with supported electrodes— with capacitance values orders of magnitude smaller than those used in traditional IPGs. Such improved circuitry operates by alternating the direction of the current through the DC- blocking capacitor during the provision of a therapeutic current pulse. Such smaller-value DC-blocking capacitors do not take up significant space in the IPG, or surface area on the IPG's PCB. Additionally, the improved circuitry includes the ability to measure the current amplitude provided to selected electrodes— for example, to ensure that the sources are actually providing a prescribed current amplitude to the patient's tissue— and to provide for perfect active charge recovery.

    Abstract translation: 公开了用于可植入脉冲发生器（IPG）的改进的电路，其允许使用小得多的隔直流电容器与支持的电极一起使用 - 电容值比传统IPG中使用的电容值小一个数量级。 这种改进的电路通过在提供治疗电流脉冲期间交替通过隔直流电容器的电流的方向来工作。 这种较小值的隔直流电容器不占用IPG或IPG PCB上的表面积的显着空间。 此外，改进的电路包括测量提供给所选择的电极的电流幅度的能力，例如确保电源实际上向患者的组织提供规定的电流幅度，并提供完美的有效电荷恢复。

    STIMULATION DEVICES AND METHODS FOR TREATING DRY EYE
    8.
    发明申请
    STIMULATION DEVICES AND METHODS FOR TREATING DRY EYE 审中-公开
    刺激装置和治疗干眼症的方法

    公开(公告)号：WO2016065215A1

    公开(公告)日：2016-04-28

    申请号：PCT/US2015/057023

    申请日：2015-10-22

    Applicant: OCULEVE, INC.

    Inventor： FRANKE, Manfred ,  LOUDIN, James, Donald ,  WARDLE, John ,  HOLDBROOK, Mark, Jeffrey

    IPC: A61N1/36

    CPC classification number: A61N1/36046 ,  A61N1/0526 ,  A61N1/0546 ,  A61N1/3606 ,  A61N1/36146 ,  A61N1/37205 ,  A61N1/37247 ,  A61N1/3756 ,  A61N1/3758

    Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.

    Abstract translation: 本文描述了用于治疗干眼症，疲劳的眼睛或其它形式的眼部不适的装置和方法，例如由隐形眼镜。 方法通常包括将空间和/或时间图案化的刺激应用于位于眼睛或鼻部区域中的一个或多个解剖结构。 电刺激可以引起激活泪腺的反射，或者可以直接激活支配泪腺的泪腺或神经以产生泪液。 所述装置可以是可植入的或手持式的，并且可以被配置为递送所描述的空间和/或时间图案化的刺激图案。

    SYSTEMS AND METHODS FOR PATIENT REHABILITATION USING BRAIN STIMULATION
    9.
    发明申请
    SYSTEMS AND METHODS FOR PATIENT REHABILITATION USING BRAIN STIMULATION 审中-公开
    使用脑刺激进行患者康复的系统和方法

    公开(公告)号：WO2016049618A1

    公开(公告)日：2016-03-31

    申请号：PCT/US2015/052570

    申请日：2015-09-28

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： KATNANI, Husam ,  ESKANDER, Emad, N.

    IPC: A61N1/36

    CPC classification number: A61N1/36103 ,  A61N1/025 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/36192 ,  A61N1/36196

    Abstract: Systems and methods are provided for stimulating the brain of a patient to treat a medical condition. In some aspects, a method includes positioning a stimulating device comprising electrical contacts configured to electrically stimulate locations associated with a patient's brain, and initiating a rehabilitation process to include the patient performing a task. The method also includes acquiring feedback from the patient at least while the patient is performing the task, generating, based on the acquired feedback, electrical stimulations to treat the medical condition of the patient. In some aspects, the method further includes generating a report indicative of a patient performance.

    Abstract translation: 提供系统和方法用于刺激患者的大脑以治疗医疗状况。 在一些方面，一种方法包括定位刺激装置，其包括被配置为电刺激与患者的大脑相关联的位置的电触点，以及启动康复过程以包括执行任务的患者。 该方法还包括至少在患者执行任务时从患者获得反馈，基于获取的反馈产生电刺激以治疗患者的医疗状况。 在一些方面，所述方法还包括生成指示患者表现的报告。

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