公开(公告)号：WO2016205737A3

公开(公告)日：2017-02-02

申请号：PCT/US2016038222

申请日：2016-06-17

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： LU TIMOTHY KUAN-TA ,  NISSIM LIOR ,  WU MING-RU

IPC: C12N15/00 ,  A61K39/395 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/63 ,  C12Q1/68

CPC classification number: G01N33/6845

Abstract: Aspects of the present disclosure provide a platform that triggers potent and effective immunotherapy against tumors from within tumors themselves, thus overcoming limitations of existing cancer immunotherapies and tumor-detecting gene circuits.

Abstract translation: 本公开的方面提供了一个平台，其触发对肿瘤本身内的肿瘤的有效和有效的免疫治疗，从而克服了现有的癌症免疫疗法和肿瘤检测基因电路的限制。