公开(公告)号：WO2021258062A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/038283

申请日：2021-06-21

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： BABAEE, Sahab ,  ALBAGHDADI, Mazen ,  CHOWDHURY, Mohammed ,  TRAVERSO, Carlo

IPC分类号： A61F2/86 ,  A61F2/07 ,  A61F2/848 ,  A61B17/3207 ,  A61B17/00 ,  A61F2/00 ,  A61F2/93

摘要： Herein is described a stent platform capable of intravascular local delivery of therapeutics through multipoint injection of drug agents into the vascular walls and endocardial surfaces. More specifically, an endovascular injectable stent made of kirigami skin is wrapped around a soft linear actuator and used for intravascular local drug delivery of therapeutics. This platform addresses an unmet need of treating aortic stenosis and atherosclerotic cardiovascular disease.