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公开(公告)号：WO2021116469A2
公开(公告)日：2021-06-17
申请号：PCT/EP2020/085863
申请日：2020-12-11
IPC分类号： C07K14/47 , A61K38/17 , C12N15/62 , A61K38/00 , C07K16/28 , C07K16/082 , C07K16/30 , C07K16/3069 , C07K2317/32 , C07K2317/73 , C07K2317/74 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： The present invention relates to a method of producing recombinant binding proteins with binding specificity for a peptide-MHC (pMHC) complex. The invention also relates to recombinant binding proteins comprising one, two or more designed repeat domain(s), preferably designed ankyrin repeat domain(s), with binding specificity for a pMHC complex, and to such binding proteins which further comprise a binding agent having binding specificity for a protein expressed on the surface of an immune cell, preferably a T-cell. In addition, the invention relates to nucleic acids encoding such binding proteins or repeat domains, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, including cancer, infectious diseases and autoimmune diseases.
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公开(公告)号：WO2022190016A1
公开(公告)日：2022-09-15
申请号：PCT/IB2022/052126
申请日：2022-03-09
发明人： BIANCHI, Matteo , RESCHKE, Nina , GRIMM, Sebastien , REICHEN, Christian , SCHLERETH, Bernd , LEVITSKY, Victor
IPC分类号： A61P35/02 , C07K16/28 , C07K16/46 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/2803 , C07K16/2809 , C07K16/2866 , C07K16/2875 , C07K2317/31 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20
摘要： The present invention relates to recombinant multi-specific proteins comprising binding agents with binding specificity for different targets., such as, e.g, CD3, CD33, CD123 and CD70. In addition, the invention relates to nucleic acids encoding such mutt-specific proteins, pharmaceutical compositions comprising such proteins or nucleic- acids, and the use of such binding proteins, nucleic acids or pharmaceutical- compositions in methods for treating or diagnosing diseases, such as cancer, e.g.. acute myeloid leukaemia (AML), In a mammal, including a human.
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公开(公告)号：WO2021229067A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062860
申请日：2021-05-14
发明人： RIGAMONTI, Nicolo , DOMKE, Clara , CALABRO, Valérie Perrine , TRAIL SMITH, Pamela Anna , LEVITSKY, Victor , VEITONMÄKI, Niina Elisabet
IPC分类号： C07K14/47 , C07K14/765 , C07K14/705 , C12N9/48 , A61K38/00 , A61P35/00
摘要： The present invention relates to multispecific proteins comprising designed ankyrin repeat domains with binding specificity for different targets, such as, e.g. CD40 and FAR. In addition, the invention relates to nucleic acids encoding such multispecific proteins, pharmaceutical compositions comprising such multispecific proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, in a mammal, including a human.
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公开(公告)号：WO2020245746A1
公开(公告)日：2020-12-10
申请号：PCT/IB2020/055247
申请日：2020-06-03
IPC分类号： C07K14/435
摘要： This disclosure relates to multispecific recombinant proteins useful for the treatment of cancer.
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公开(公告)号：WO2021116470A2
公开(公告)日：2021-06-17
申请号：PCT/EP2020/085864
申请日：2020-12-11
IPC分类号： C07K14/47 , A61K38/17 , C12N15/62 , C07K14/435
摘要： The present invention relates to a method of producing recombinant binding proteins with binding specificity for a peptide-MHC (pMHC) complex. The invention also relates to recombinant binding proteins comprising one, two or more designed repeat domain(s), preferably designed ankyrin repeat domain(s), with binding specificity for a pMHC complex, and to such binding proteins which further comprise a binding agent having binding specificity for a protein expressed on the surface of an immune cell, preferably a T-cell. In addition, the invention relates to nucleic acids encoding such binding proteins or repeat domains, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, including cancer, infectious diseases and autoimmune diseases.
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公开(公告)号：WO2022129428A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/086331
申请日：2021-12-16
发明人： GRIMM, Sebastian , RESCHKE, Nina , REICHEN, Christian , SCHLERETH, Bernd , LEVITSKY, Victor , JEANBART, Laura
摘要： The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for CD3. In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods of disease-localized activation of T cells, and in methods of treating diseases, such as infectious diseases or cancer, in a mammal, including a human.
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公开(公告)号：WO2020245175A1
公开(公告)日：2020-12-10
申请号：PCT/EP2020/065319
申请日：2020-06-03
IPC分类号： C07K14/705 , A61K39/00 , C07K16/28 , C12N15/62 , A61P35/00
摘要： The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for 4-1 BB (CD137). In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for activating 4-1 BB in cells expressing 4-1 BB, e.g., tumor-localized T-lymphocytes, and for treating or diagnosing diseases, such as cancer, in a mammal, including a human.
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