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    RECOMBINANT 4-1BB BINDING PROTEINS AND THEIR USE
    1.
    发明申请
    RECOMBINANT 4-1BB BINDING PROTEINS AND THEIR USE 审中-公开

    公开(公告)号：WO2020245175A1

    公开(公告)日：2020-12-10

    申请号：PCT/EP2020/065319

    申请日：2020-06-03

    申请人： MOLECULAR PARTNERS AG

    发明人： REICHEN, Christian ,  LINK, Alexander ,  HEPP, Julia ,  LEVITSKY, Victor

    IPC分类号： C07K14/705 ,  A61K39/00 ,  C07K16/28 ,  C12N15/62 ,  A61P35/00

    摘要： The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for 4-1 BB (CD137). In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for activating 4-1 BB in cells expressing 4-1 BB, e.g., tumor-localized T-lymphocytes, and for treating or diagnosing diseases, such as cancer, in a mammal, including a human.