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    METHODS FOR DERMAL FILLING USING MICRONEEDLES
    1.
    发明申请
    METHODS FOR DERMAL FILLING USING MICRONEEDLES 审中-公开
    使用麦克风进行真空填充的方法

    公开(公告)号：WO2008072229A2

    公开(公告)日：2008-06-19

    申请号：PCT/IL2007/001527

    申请日：2007-12-11

    Applicant: NANOPASS TECHNOLOGIES LTD. ,  LEVIN, Yotam ,  ALMAGOR, Yotam ,  LAVI, Gilad ,  YESHURUN, Yehoshua ,  WOLLOCH, Lior

    Inventor： LEVIN, Yotam ,  ALMAGOR, Yotam ,  LAVI, Gilad ,  YESHURUN, Yehoshua ,  WOLLOCH, Lior

    IPC: A61B18/18

    CPC classification number: A61M37/0015 ,  A61M2037/0023

    Abstract: A device and method for dermal filling using microneedles is disclosed. A microneedle device including at least two hollow microneedles arranged in at least one row, the row defining a treatment vector of the device, is used to intradermally inject a dermal filler composition into the skin of a subject along a pre-defined line in the skin where dermal filling, cosmetic repair or augmentation of tissue is desired. The device and method reduces or eliminates pain, and provides a safer, more effective administration method. The method also enables reduction in the required number of treatments (and re-treatments) due to an improved stability of the filler in these shallower depths within the skin; smoother contours due to a more even distribution of the filler within the skin; easier application for curved wrinkle lines (as opposed to hypodermic needles that are long and straight); and filling of very fine lines and wrinkles which are not accessible with regular needles.

    Abstract translation: 公开了一种使用微针进行皮肤填充的装置和方法。 一种微针装置，其包括至少两个布置在至少一排的中空微针，该排定义该装置的治疗载体的行用于沿着皮肤中的预定义线皮内注射真皮填充剂组合物到受试者的皮肤中 需要皮肤填充，美容修复或组织的增加。 该装置和方法减少或消除疼痛，并提供更安全，更有效的给药方法。 该方法还能够减少所需数量的处理（和再处理），这是由于填充剂在皮肤中较浅深度的稳定性得到改善; 由于填料在皮肤内更均匀的分布，平滑的轮廓; 更容易应用于弯曲的皱纹线（与长而直的皮下注射针相反）; 并填充非常细的线条和皱纹，这是不能用普通针。

    INTRADERMAL MINI-NEEDLE INTERFACE AND ASSOCIATED DEVICES AND METHODS
    2.
    发明申请
    INTRADERMAL MINI-NEEDLE INTERFACE AND ASSOCIATED DEVICES AND METHODS 审中-公开
    内部微针接口及相关设备及方法

    公开(公告)号：WO2010064211A2

    公开(公告)日：2010-06-10

    申请号：PCT/IB2009/055493

    申请日：2009-12-03

    Applicant: NANOPASS TECHNOLOGIES LTD. ,  SEFI, Yoel ,  LEVIN, Yotam ,  YESHURUN, Yehoshua ,  AGIAN, Nadav

    Inventor： SEFI, Yoel ,  LEVIN, Yotam ,  YESHURUN, Yehoshua ,  AGIAN, Nadav

    IPC: A61M5/162

    CPC classification number: A61M5/46 ,  A61M5/162 ,  A61M5/30 ,  A61M5/3293 ,  A61M5/3298 ,  A61M2005/341 ,  A61M2005/342

    Abstract: An intradermal mini-needle interface has a penetration limiter providing a skin contact edge and a hollow hypodermic needle having a beveled penetrating portion protruding forward beyond the skin contact edge by no more than 3 mm. At least one skin contact surface defines a skin contact plane parallel to, or at a shallow angle to, the needle axis. The skin contact plane intersects the skin contact edge substantially at a base of the penetrating portion. Preferably, the penetration limiter is asymmetric under rotation about the needle axis.

    Abstract translation: 皮内微针接口具有提供皮肤接触边缘的穿透限制器和具有向上突出超过皮肤接触边缘的不大于3mm的斜面穿透部分的中空皮下注射针。 至少一个皮肤接触表面限定与针轴平行或以较小角度的皮肤接触平面。 皮肤接触面基本上在穿透部分的基部与皮肤接触边缘相交。 优选地，穿透限制器围绕针轴线旋转是不对称的。

    INJECTION DEVICE AND METHOD
    3.
    发明申请
    INJECTION DEVICE AND METHOD 审中-公开

    公开(公告)号：WO2008047359A3

    公开(公告)日：2008-04-24

    申请号：PCT/IL2007/001244

    申请日：2007-10-17

    Applicant: NANOPASS TECHNOLOGIES LTD. ,  CATCHPOLE, Ian Richard ,  YESHURUN, Yehoshua ,  LEVIN, Yotam ,  ALMAGOR, Yotam ,  LAVI, Gilad ,  HEFETZ, Meir ,  SEFI, Yoel

    Inventor： CATCHPOLE, Ian Richard ,  YESHURUN, Yehoshua ,  LEVIN, Yotam ,  ALMAGOR, Yotam ,  LAVI, Gilad ,  HEFETZ, Meir ,  SEFI, Yoel

    IPC: A61M5/00 ,  A61M31/00

    Abstract: An injection device and corresponding method for delivery of an injection fluid into a flexible biological barrier employ a substrate (1) having a surface which includes a contact surface (3) to be brought into facing contact with the surface of the biological barrier, a second surface (4) distanced from the contact surface (3) by a pivot region (5), the angle (A) between the projection (5') of the pivot region (5) and the second surface (4) being in the range 20?-50?, and a microneedle (20) projecting from the substrate surface at a microneedle location on or adjacent to the contact surface (3). The disposition of the contact (3) and second (4) surfaces, the pivot region (5) and the microneedle (20) is such that the contact surface (3) of the device can be brought into facing contact with the surface of the biological barrier such that the microneedle (20) becomes inserted into the biological barrier, the substrate (1) can then be rotated about the pivot region (5) such that the microneedle (20) engaged with the biological barrier moves in an arc and pulls the biological barrier so engaged in a direction perpendicular to the surface of the biological barrier until the second surface (4) comes into facing contact with the biological barrier.

    METHOD FOR PRODUCING MICRONEEDLE STRUCTURES EMPLOYING ONE-SIDED PROCESSING
    4.
    发明申请
    METHOD FOR PRODUCING MICRONEEDLE STRUCTURES EMPLOYING ONE-SIDED PROCESSING 审中-公开
    生产采用单面加工的微结构结构的方法

    公开(公告)号：WO2008142681A2

    公开(公告)日：2008-11-27

    申请号：PCT/IL2008/000683

    申请日：2008-05-20

    Applicant: NANOPASS TECHNOLOGIES LTD. ,  YESHURUN, Yehoshua ,  DE BOER, Meint ,  BERENSCHOT, Johan Willem

    Inventor： YESHURUN, Yehoshua ,  DE BOER, Meint ,  BERENSCHOT, Johan Willem

    IPC: H01L21/302

    CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

    Abstract: A method for forming a hollow microneedle structure includes processing the front side of a wafer to form at least one microneedle projecting from a substrate and a through-bore passing through the microneedle and through a thickness of the substrate. An entire length of the through-bore is formed by a dry etching process performed from the front side of the wafer. Most preferably, upright surfaces of the microneedle structure and the through bore of the structure are formed by dry etching performed via a single mask with differing depths obtained by harnessing aspect ratio limitations of the dry etching process.

    Abstract translation: 用于形成中空微针结构的方法包括处理晶片的前侧以形成从基底突出的至少一个微针和穿过微针并穿过基底的厚度的通孔。 通孔的整个长度通过从晶片的前侧进行的干蚀刻工艺形成。 最优选地，微针结构的直立表面和结构的通孔通过经由通过利用干蚀刻工艺的纵横比限制而获得的不同深度的单个掩模进行的干蚀刻形成。

    MICRONEEDLE STRUCTURES AND CORRESPONDING PRODUCTION METHODS EMPLOYING A BACKSIDE WET ETCH
    5.
    发明申请
    MICRONEEDLE STRUCTURES AND CORRESPONDING PRODUCTION METHODS EMPLOYING A BACKSIDE WET ETCH 审中-公开
    麦克风结构和相应的生产方法

    公开(公告)号：WO2008114252A2

    公开(公告)日：2008-09-25

    申请号：PCT/IL2008/000374

    申请日：2008-03-18

    Applicant: NANOPASS TECHNOLOGIES LTD ,  YESHURUN, Yehoshua

    Inventor： YESHURUN, Yehoshua

    IPC: H01L21/8242

    CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C2201/0132 ,  B81C2201/0133 ,  Y10T428/13

    Abstract: A method for forming a hollow microneedle structure includes processing the front side of a wafer (10) to form at least one microneedle (30) projecting from a substrate with a first part (18) of a through-bore, formed by a dry etching process, passing through the microneedle and through a part of a thickness of the substrate. The backside of the wafer (10) is also processed to form a second part (16) of the through-bore by a wet etching process.

    Abstract translation: 一种用于形成中空微针结构的方法包括处理晶片（10）的前侧以形成至少一个从基板突出的微针（30），所述微针具有通过干蚀刻形成的通孔的第一部分（18） 过程中，穿过微针并穿过衬底的厚度的一部分。 晶片（10）的背面也被处理以通过湿蚀刻工艺形成通孔的第二部分（16）。

    DUAL CHAMBER INJECTOR INTERGRATED WITH MICRO-NEEDLES
    6.
    发明申请
    DUAL CHAMBER INJECTOR INTERGRATED WITH MICRO-NEEDLES 审中-公开
    双室注射器与微针相结合

    公开(公告)号：WO2008007370A2

    公开(公告)日：2008-01-17

    申请号：PCT/IL2007/000868

    申请日：2007-07-11

    Applicant: NANOPASS TECHNOLOGIES LTD. ,  YESHURUN, Yehoshua ,  LEVIN, Yotam ,  LAVI, Gilad

    Inventor： YESHURUN, Yehoshua ,  LEVIN, Yotam ,  LAVI, Gilad

    IPC: A61M5/32

    CPC classification number: A61M5/19 ,  A61M5/284 ,  A61M37/0015 ,  A61M2005/1787 ,  A61M2005/3132 ,  A61M2037/0023

    Abstract: This invention relates to a medical injection system for the intradermal injection of two or more fluid substances via micro-needles, and most preferably via a linear array of micro-needles, although the array need not be linear. Injecting two fluid substances contained in two separate chambers of the delivery device can be done by various methods. These methods may be generally categorized as, a) sequential injection, b) simultaneous injection, c) parallel injection and d) closed-loop injection processes. The present invention includes devices configured to perform all three of these methods.

    Abstract translation: 本发明涉及一种用于通过微针皮内注射两种或多种流体物质的医疗注射系统，最优选通过微针的线性阵列进行皮内注射，尽管阵列不必是线性的。 可以通过各种方法注射包含在输送装置的两个分开的室中的两种流体物质。 这些方法通常可分为：a）顺序注入，b）同步注入，c）平行注入和d）闭环注入过程。 本发明包括被配置为执行这三种方法的设备。

    ARMOR PANEL
    10.
    发明申请
    ARMOR PANEL 审中-公开
    装甲板

    公开(公告)号：WO2011064776A1

    公开(公告)日：2011-06-03

    申请号：PCT/IL2010/000988

    申请日：2010-11-25

    Applicant: PLASAN SASA LTD. ,  YESHURUN, Yehoshua

    Inventor： YESHURUN, Yehoshua

    IPC: F41H5/04

    CPC classification number: F41H5/0471

    Abstract: An armor panel configured for protecting a body from an incoming projectile having a movement axis and configured for spinning about the axis. The armor panel comprises a plurality of armor strips attached to each other. The panel has a front face configured for facing the projectile and a rear face configured for facing away from the front face. The strips are arranged within the armor panel so that at least a majority thereof are oriented transversely to at least the front face of the armor panel. At least one of the following conditions applies: (i) the strips are connected to each other so that a static friction force Fs1 needs to be applied in order to at least partially disconnect them, and (ii) the material from which at least some of the armor strips are made is such that a static friction force Fs2 needs to be applied in order to at least partially disconnect a portion thereof from its remainder. At least during penetration of the spinning projectile into the armor panel, a dynamic friction force between the spinning projectile and the strips exceeds, under the respective condition, at least one of the Fs1 and Fs2.

    Abstract translation: 一种装甲面板，其构造成用于保护身体免受具有移动轴线并且被配置为围绕轴线旋转的入射射弹。 装甲板包括彼此附接的多个铠装条。 所述面板具有被配置为面对所述射弹的前表面和被配置为面向远离所述前表面的后表面。 条带布置在护甲板内，使得其至少大部分横向于至少在护甲板的前表面定向。 以下条件中的至少一个适用于：（i）条彼此连接，使得需要施加静摩擦力Fs1以使其至少部分地断开它们，以及（ii）至少一些 制成的防护条使得需要施加静摩擦力Fs2以使其部分与其余部分至少部分地断开。 至少在将喷射弹穿入装甲板中时，纺丝抛射体和条带之间的动摩擦力在各自的条件下超过Fs1和Fs2中的至少一个。

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