公开(公告)号：WO2017010945A1

公开(公告)日：2017-01-19

申请号：PCT/SG2016/050333

申请日：2016-07-15

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  POTROZ, Michael Graeme ,  MUNDARGI, Raghavendra Chaluvayya ,  PARK, Jae Hyeon ,  JACKMAN, Joshua Alexander

IPC: A61K9/50 ,  A61K9/52 ,  A23P10/30 ,  A61K8/11 ,  A61Q19/10

CPC classification number: A23P10/30 ,  A01N25/00 ,  A01N25/08 ,  A61K8/0279 ,  A61K8/11 ,  A61K8/922 ,  A61K8/9706 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/5063 ,  A61K2800/10 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/56 ,  A61Q19/00 ,  A61Q19/10

Abstract: In one aspect, provided herein are whole spores engineered to capsulate a compound(s) or substance(s). In certain embodiments, the whole spore encapsulating the compound(s) or substance(s) is coated with or co-encapsulated with a hydrogel or other agent(s) to control the rate release of the compound(s) or substance(s) from the spore. In another aspect, provided herein are methods of producing whole spores encapsulating a compound(s) or substance(s). In another aspect, provided herein are formulations comprising either a whole spore, or a whole spore encapsulating a compound(s) or substance(s), and uses of those formulations.

Abstract translation: 在一个方面，本文提供了工程化以包封化合物或物质的整个孢子。 在某些实施方案中，包封化合物或物质的整个孢子用水凝胶或其它试剂包被或共包裹以控制化合物或物质的速率释放， 从孢子。 在另一方面，本文提供了制备包封化合物或物质的全部孢子的方法。 在另一方面，本文提供了包含整个孢子或包封化合物或物质的整个孢子的制剂以及这些制剂的用途。

公开(公告)号：WO2015041608A1

公开(公告)日：2015-03-26

申请号：PCT/SG2014/000449

申请日：2014-09-19

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  JACKMAN, Joshua Alexander

IPC: A61K9/127 ,  A61K47/44 ,  G01N33/543

CPC classification number: B01J13/04 ,  A61K9/1271 ,  B05D1/007 ,  B05D3/104 ,  B05D3/142 ,  G01N33/54393

Abstract: The invention relates to a method of controlling adsorption of lipid molecules onto a solid support by tuning the steric-hydration force of the lipid vesicles and the surface of the solid support, such that the solid support either has a stabilized lipid bilayer adsorbed thereon or is resistant to adsorption of lipid molecules.

Abstract translation: 本发明涉及通过调节脂质囊泡和固体支持物表面的空间水合力来控制脂质分子在固体支持物上的吸附的方法，使得固体支持物具有在其上吸附的稳定的脂质双层或者是 耐脂质分子的吸附。

公开(公告)号：WO2018151679A1

公开(公告)日：2018-08-23

申请号：PCT/SG2018/050072

申请日：2018-02-14

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  JACKMAN, Joshua Alexander

IPC: C07F9/10 ,  B32B9/04

Abstract: A method of preparing a solid-supported phospholipid bilayer is provided. The method comprises: a) a first step of providing a solution comprising a bicellar mixture of a long-chain phospholipid and a short-chain phospholipid; b) at least one second step of decreasing the temperature of the solution to below 0 °C, increasing the temperature to above room temperature and causing the solution to be blended; and c) a third step of depositing the solution obtained after the second step on a surface of a support, wherein the concentration of the long-chain phospholipid in the solution is at most 0.1 mg/mL, for obtaining a solid-supported phospholipid bilayer. A solid-supported phospholipid layer obtained by the method as defined above is also provided.

公开(公告)号：WO2016209173A1

公开(公告)日：2016-12-29

申请号：PCT/SG2016/050291

申请日：2016-06-24

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  JACKMAN, Joshua Alexander

IPC: C07K7/08 ,  A61K38/04 ,  A61P31/00

CPC classification number: C07K14/001 ,  A01N25/04 ,  A01N47/44 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K38/00 ,  A61K47/60 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  C07K7/08 ,  C07K14/005 ,  C07K14/1833 ,  Y02A50/385

Abstract: Provided herein are anti-infective peptides and uses thereof, in one embodiment, provided herein is a peptide that is 16 to 26 amino acid residues in length and comprises the following amino acid sequence: X 1 X 2 SWLRDX 3 X 4 TX 5 LQSX 6 L, wherein X 1 is S or G or A; X 2 is S or G, X 3 is V or I, X 4 is W or L, X 5 is W, K, A or L and X 6 is W, K, L or A. The anti-infective peptides may comprise D amino acids, L amino acids or a combination thereof. In certain embodiments, the anti-infective peptides are peglyated, modified to include a hydrophilic polymer, stapled or iipidated. Also provided herein are compositions comprising the anti-infective peptides, and methods of treatment and disinfecting using the anti-infective peptides. The anti-infective peptides provided herein are useful against a broad spectrum of bacteria and viruses.

Abstract translation: 本文提供了抗感染肽及其用途，在一个实施方案中，本文提供了长度为16至26个氨基酸残基的肽，并且包含以下氨基酸序列：X1X2SWLRDX3X4TX5LQSX6L，其中X1为S或G或A; X2是S或G，X3是V或I，X4是W或L，X5是W，K，A或L，X6是W，K，L或A.抗感染肽可以包含D氨基酸，L 氨基酸或其组合。 在某些实施方案中，抗感染肽被PEG化，被修饰以包括亲水性聚合物，被缝合或脂质化。 本文还提供了包含抗感染肽的组合物，以及使用抗感染肽的治疗和消毒方法。 本文提供的抗感染肽可用于广谱的细菌和病毒。

公开(公告)号：WO2015112089A2

公开(公告)日：2015-07-30

申请号：PCT/SG2015/000014

申请日：2015-01-21

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  TABAEI AGHDA, Seyed Ruhollah ,  JACKMAN, Joshua Alexander

IPC: B05D1/36

CPC classification number: G01N33/54306 ,  G01N33/573 ,  G01N33/92

Abstract: The present invention is directed to a method for forming a hydration layer/lipid bilayer structure on a solid support by contacting a solution comprising at least one polar lipid and a water-miscible alcohol as a solvent with the solid support; and adding water to said solution at a predetermined rate, thus inducing formation of a hydration layer on the solid support surface and formation of a planar lipid bilayer on the hydration layer, wherein the hydration layer has an average thickness of at least 2 nm as well as the thus obtained solid supports with a hydration layer/lipid bilayer structure.

Abstract translation: 本发明涉及通过使包含至少一种极性脂质和与水可混溶的醇作为溶剂的溶液与固体支持物接触在固体支持物上形成水合层/脂质双层结构的方法; 并以预定的速率向所述溶液中加入水，从而在固体支持物表面上引起水合层的形成并在水合层上形成平面脂质双层，其中水合层的平均厚度至少为2nm 作为由此获得的具有水合层/脂质双层结构的固体载体。