公开(公告)号：WO2019097400A1

公开(公告)日：2019-05-23

申请号：PCT/IB2018/058919

申请日：2018-11-13

Applicant: GREEM PHARM S.R.L.

Inventor： CATANESE, Maurizio Danilo ,  DAL MORO, Giulia

IPC: A61K31/295 ,  A61K33/26 ,  A61K33/34 ,  A23L33/15 ,  A23L33/16 ,  A61K9/50 ,  A61K45/06 ,  A61K31/30 ,  A61K31/375

CPC classification number: A61K9/5042 ,  A23L33/15 ,  A23L33/16 ,  A61K9/5026 ,  A61K9/5063 ,  A61K9/5078 ,  A61K31/375 ,  A61K31/519 ,  A61K33/26 ,  A61K33/34 ,  A61K45/06 ,  A61P7/06 ,  A61K2300/00

Abstract: The present invention discloses an oral administration form comprising an association of Fe(II) and Cu(II). The oral administration form finds advantageous application as a food supplement for the supplementation of iron and copper, without side effects for the stomach and intestine.

公开(公告)号：WO2016140716A1

公开(公告)日：2016-09-09

申请号：PCT/US2015/063266

申请日：2015-12-01

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： ROSSEN, Ninna, S. ,  SIA, Samuel, K. ,  GILLETTE, Brian, M.

IPC: A61P3/04 ,  C12N5/074 ,  C12N5/0775

CPC classification number: A61K35/44 ,  A61K9/0019 ,  A61K9/5063 ,  A61K35/28 ,  C12N5/0691 ,  C12N5/0697 ,  C12N2501/02 ,  C12N2501/115 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2501/81 ,  C12N2502/1352 ,  C12N2502/1358 ,  C12N2502/28 ,  C12N2539/00

Abstract: Spheroid microtissues can mimic native tissue-like structure and function, and are thus useful for broad research applications and regenerative medicine. Disclosed embodiments include spheroid production methods that are high-throughput, suitable for efficient production, maintainable over long-term culture, and/or offer repeatable control over size distribution. Embodiments disclosed include spheroids that include blood vessels, which are proven useful for tissue survival and function. Embodiments include spheroids with functional, blood-perfused vascular networks upon injection in vivo. Dissolvable hydrogel microwell arrays enable high throughput parallel formation of spheroids in a single pipetting step and easy retrieval for downstream applications. Dynamic culture conditions stimulated endothelial cell and mesenchymal stem cell cocultures to self-organize and form blood-vessel structures within the spheroids. Vascularized spheroids were injected into mice and rapid perfusion of implant vessels within 4-7 days were observed.

Abstract translation: 球状微结构可以模拟天然组织样结构和功能，因此可用于广泛的研究应用和再生医学。 公开的实施例包括高通量的球形生产方法，适合于有效生产，可长期培养可维持，和/或提供可重复控制的尺寸分布。 公开的实施方案包括包括血管的球体，其被证明可用于组织存活和功能。 实施方案包括在体内注射时具有功能性，血液灌注血管网络的球体。 可溶性水凝胶微孔阵列可以在单次移液步骤中实现高通量平行形成球体，并为下游应用轻松检索。 动态培养条件刺激内皮细胞和间充质干细胞共培养，以自组织形成球状体内的血管结构。 将血管化球体注射入小鼠，并观察4-7天内植入血管的快速灌注。

公开(公告)号：WO2012002759A3

公开(公告)日：2012-05-03

申请号：PCT/KR2011004820

申请日：2011-06-30

Applicant: AEON MEDIX INC ,  GHO YONG SONG ,  JANG SU CHUL ,  KIM YOON KEUN ,  KIM OH YOUN

Inventor： GHO YONG SONG ,  JANG SU CHUL ,  KIM YOON KEUN ,  KIM OH YOUN

IPC: A61K9/133 ,  A61K35/74 ,  A61K47/40 ,  A61K49/08 ,  A61K49/18

CPC classification number: A61K47/48838 ,  A61K9/127 ,  A61K9/5063 ,  A61K38/162 ,  A61K38/1825 ,  A61K38/1866 ,  A61K38/20 ,  A61K38/21 ,  A61K39/0011 ,  A61K39/02 ,  A61K39/39 ,  A61K45/06 ,  A61K47/00 ,  A61K47/10 ,  A61K47/40 ,  A61K47/46 ,  A61K47/6917 ,  A61K49/0017 ,  A61K49/0045 ,  A61K49/0097 ,  A61K2039/55555 ,  B82Y5/00 ,  C07K14/71 ,  C07K2319/00 ,  Y10S977/773

Abstract: The present invention relates to microvesicles derived from a protoplast which is a bacterial, archaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast of the present invention enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.

Abstract translation: 本发明涉及源自原生质体的微泡，所述原生质体是除去细胞壁的细菌，古细菌，真菌或植物细胞等。 来源于本发明的原生质体的微泡使得能够自由加载诊断，治疗，疫苗，靶诱导，与靶细胞的细胞膜融合，体内和体外副作用的减少，稳定性改善以及 并且允许将治疗材料，诊断材料和/或疫苗材料特异性递送至特定的组织或细胞。

公开(公告)号：WO2011096665A3

公开(公告)日：2012-01-05

申请号：PCT/KR2011000541

申请日：2011-01-26

Applicant: HANMI HOLDINGS CO LTD ,  WOO JONG SOO ,  PARK JAE HYUN ,  KIM YONG IL ,  NA YOUNG JUN ,  CHOI JUN YOUNG ,  LEE YUN AH

Inventor： WOO JONG SOO ,  PARK JAE HYUN ,  KIM YONG IL ,  NA YOUNG JUN ,  CHOI JUN YOUNG ,  LEE YUN AH

IPC: A61K31/60 ,  A61K31/40 ,  A61K31/505 ,  A61P9/00

CPC classification number: A61K31/40 ,  A61K9/1652 ,  A61K9/5063 ,  A61K9/5084 ,  A61K31/505 ,  A61K31/616 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided is a complex formulation for the prevention or treatment of cardiovascular diseases, comprising: a) aspirin coated with a barrier containing a hydrophobic additive; and b) an HMG-CoA reductase inhibitor, which has improved storage stability by preventing the deterioration in the stability of HMG-CoA reductase which is caused by salicylic acid, thereby being used in the treatment of hypertension and hypercholesterolemia.

Abstract translation: 提供了用于预防或治疗心血管疾病的复合制剂，其包括：a）涂覆有含有疏水性添加剂的屏障的阿司匹林; 和b）HMG-CoA还原酶抑制剂，通过防止由水杨酸引起的HMG-CoA还原酶的稳定性降低而提高储存稳定性，从而用于治疗高血压和高胆固醇血症。

公开(公告)号：WO2011041083A1

公开(公告)日：2011-04-07

申请号：PCT/US2010/048339

申请日：2010-09-10

Applicant: PROVIMI NORTH AMERICA, INC. ,  COLLINGS, George, F. ,  COCHRAN, Keith, D. ,  PEEDEN, Gregory, Scott

Inventor： COLLINGS, George, F. ,  COCHRAN, Keith, D. ,  PEEDEN, Gregory, Scott

IPC: A61K35/74 ,  C12N1/21

CPC classification number: A61K9/0031 ,  A23K20/158 ,  A23K40/35 ,  A23K50/10 ,  A61K9/1664 ,  A61K9/5063

Abstract: The present invention relates to an agglomerated particle enrobed in a hydrophobic coating composition comprised of highly hydrogenated oils, waxes, and glycerides. The particle is specifically comprised of one or more biological agents of nutritional or biological value to a ruminant, which are agglomerated with a binder. The particle is specifically formed to have a substantially round surface with minimal surface irregularities. Thus, the particle is more uniformly coated with the hydrophobic coating composition, and the biological agents are better insulated from the degradation within the rumen.

Abstract translation: 本发明涉及一种由高度氢化的油，蜡和甘油酯组成的疏水性涂料组合物中的凝聚颗粒。 颗粒特异性地包含一种或多种对反刍动物具有营养或生物学价值的生物制剂，其与粘合剂结合。 颗粒特别地形成为具有最小表面不规则性的大致圆形表面。 因此，颗粒更均匀地涂覆有疏水涂层组合物，并且生物制剂与瘤胃内的降解更好地隔离。

公开(公告)号：WO2009077749A1

公开(公告)日：2009-06-25

申请号：PCT/GB2008/004150

申请日：2008-12-17

Applicant: UNIVERSITY OF HULL ,  ATKIN, Stephen, Lawrence ,  BECKETT, Stephen, Thomas ,  DIEGO-TABOADA, Alberto ,  MACKENZIE, Grahame

Inventor： ATKIN, Stephen, Lawrence ,  BECKETT, Stephen, Thomas ,  DIEGO-TABOADA, Alberto ,  MACKENZIE, Grahame

IPC: A61K9/50 ,  A61K36/00 ,  A61K35/66

CPC classification number: A61K9/4816 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5063 ,  A61K9/5068 ,  A61K35/60 ,  A61K36/00 ,  A61K38/00 ,  C09K3/00

Abstract: A formulation containing an active substance encapsulated within an exine shell of a naturally occurring spore, together with a protective additive which is also encapsulated within the exine shell.

Abstract translation: 包含封装在天然存在的孢子的外壳内的活性物质的制剂以及还包封在外壳内的保护性添加剂。

公开(公告)号：WO2007126990A3

公开(公告)日：2008-06-26

申请号：PCT/US2007007817

申请日：2007-03-27

Applicant: NESTEC SA ,  CZARNECKI-MAULDEN GAIL ,  FILIPI IVAN

Inventor： CZARNECKI-MAULDEN GAIL ,  FILIPI IVAN

IPC: A61K31/70 ,  A61K31/355

CPC classification number: A61K35/744 ,  A23K10/18 ,  A23K20/163 ,  A23K20/174 ,  A23K20/179 ,  A23K20/20 ,  A23K20/22 ,  A23K20/24 ,  A23K20/30 ,  A23K40/30 ,  A23K50/40 ,  A23L33/135 ,  A23L33/15 ,  A23L33/16 ,  A23L33/21 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/5063 ,  A61K31/01 ,  A61K31/145 ,  A61K31/355 ,  A61K31/375 ,  A61K35/745 ,  A61K35/747 ,  A61K36/064 ,  A61K38/00 ,  A61K45/06 ,  G09B5/02 ,  G09B19/0092 ,  A61K2300/00 ,  A23V2200/08 ,  A23V2250/0644 ,  A23V2250/1578 ,  A23V2250/1588 ,  A23V2250/1592 ,  A23V2250/16 ,  A23V2250/161 ,  A23V2250/1612 ,  A23V2250/1614 ,  A23V2250/1618 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/18 ,  A23V2250/708 ,  A23V2250/712

Abstract: Dietary supplements comprising at least one probiotic and at least one of animal digest, dried brewers yeast, vitamin C; vitamin E, beta carotene, zinc proteinate, manganese proteinate, ferrous sulfate, copper proteinate, calcium iodate, and sodium selenite. The probiotics and other ingredients are present in the supplement in amounts sufficient to enhance the palatability of the probiotics and compositions containing the probiotics, enhance the immune system to augment the beneficial effects of the probiotics, or extend the life of the probiotics.

Abstract translation: 膳食补充剂包含至少一种益生菌和至少一种动物消化，干酿酒酵母，维生素C; 维生素E，β-胡萝卜素，蛋白质锌，蛋白质锰，硫酸亚铁，蛋白质铜，碘酸钙和亚硒酸钠。 益生菌和其他成分以足以增加益生菌和含有益生菌的组合物的适口性的量存在于补充物中，增强免疫系统以增加益生菌的有益效果，或延长益生菌的寿命。

公开(公告)号：WO2017010945A1

公开(公告)日：2017-01-19

申请号：PCT/SG2016/050333

申请日：2016-07-15

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  POTROZ, Michael Graeme ,  MUNDARGI, Raghavendra Chaluvayya ,  PARK, Jae Hyeon ,  JACKMAN, Joshua Alexander

IPC: A61K9/50 ,  A61K9/52 ,  A23P10/30 ,  A61K8/11 ,  A61Q19/10

CPC classification number: A23P10/30 ,  A01N25/00 ,  A01N25/08 ,  A61K8/0279 ,  A61K8/11 ,  A61K8/922 ,  A61K8/9706 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/5063 ,  A61K2800/10 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/56 ,  A61Q19/00 ,  A61Q19/10

Abstract: In one aspect, provided herein are whole spores engineered to capsulate a compound(s) or substance(s). In certain embodiments, the whole spore encapsulating the compound(s) or substance(s) is coated with or co-encapsulated with a hydrogel or other agent(s) to control the rate release of the compound(s) or substance(s) from the spore. In another aspect, provided herein are methods of producing whole spores encapsulating a compound(s) or substance(s). In another aspect, provided herein are formulations comprising either a whole spore, or a whole spore encapsulating a compound(s) or substance(s), and uses of those formulations.

Abstract translation: 在一个方面，本文提供了工程化以包封化合物或物质的整个孢子。 在某些实施方案中，包封化合物或物质的整个孢子用水凝胶或其它试剂包被或共包裹以控制化合物或物质的速率释放， 从孢子。 在另一方面，本文提供了制备包封化合物或物质的全部孢子的方法。 在另一方面，本文提供了包含整个孢子或包封化合物或物质的整个孢子的制剂以及这些制剂的用途。

公开(公告)号：WO2014140867A3

公开(公告)日：2015-01-08

申请号：PCT/IB2014001041

申请日：2014-03-14

Applicant: CAPE SPEAR PHARMACEUTICALS LTD

Inventor： BARNES DAVID ,  BARKER JONATHAN ,  HAGGERTY STEPHEN

IPC: A61K9/16 ,  A61K9/50

CPC classification number: A61K9/5073 ,  A23L33/10 ,  A61K9/5047 ,  A61K9/5063 ,  A61K31/138 ,  A61K31/34 ,  A61K31/4425 ,  G01N31/221

Abstract: Provided are novel methods and compositions for administration of pharmaceuticals to subjects with dysphagia. Pharmaceuticals are associated with beads and administered with food, beverage or cosmetic to provide ease of administration to subjects with dysphagia. Environmental indicators are associated with beads for Quality Assurance.

Abstract translation: 提供了用于向具有吞咽困难的受试者施用药物的新颖方法和组合物。 药物与珠粒相关并且与食物，饮料或化妆品一起施用以便容易地对具有吞咽困难的受试者施用。 环境指标与珠子有关质量保证。

公开(公告)号：WO2013191319A1

公开(公告)日：2013-12-27

申请号：PCT/KR2012/005510

申请日：2012-07-11

Applicant: 주식회사 아리메드 ,  윤칠석 ,  정재준 ,  성수현

Inventor： 윤칠석 ,  정재준 ,  성수현

IPC: A61K9/16 ,  A61K9/20 ,  A61K47/38 ,  A61K47/30

CPC classification number: A61K36/254 ,  A61K9/14 ,  A61K9/1688 ,  A61K9/20 ,  A61K9/2866 ,  A61K9/5047 ,  A61K9/5063 ,  A61K36/00 ,  A61K36/232 ,  A61K36/481 ,  A61K36/72 ,  A61K36/88 ,  A61K45/06

Abstract: 본 발명은 (a) 유동층 기기에 분말상의 식물, 생약 또는 한약탕제 추출물을 투입하여 유동화하면서, 상기 추출물 분말에 정제수 또는 상기 추출물 분말과 동일한 종류의 추출물의 용액을 분무하여 추출물 분말의 미세과립을 생성하는 단계; 및 (b) 유동층 기기에 상기 단계 (a)에서 생성된 미세과립을 시드로 투입하여 유동화하면서, 상기 추출물의 용액을 분무하여 소정의 크기의 과립 또는 환으로 성장시키는 단계를 포함하는 식물, 생약 또는 한약탕제 추출물을 함유하는 과립 또는 환의 제조방법에 관한 것이다. 본 발명에 의하면, 추출물을 고농도로 함유하는 과립 및 환을 제조할 수 있다.

Abstract translation: 本发明涉及一种制备含有植物，药草或传统东方汤剂提取物的颗粒或丸剂的方法，包括以下步骤：（a）将粉状植物，药草或传统东方汤剂提取物注入 流化床装置，并在提取粉末中将纯化水或提取物提取物的相同类型的提取物的溶液喷雾，同时使其流出，从而产生提取物粉末的微粒; 和（b）将步骤（a）产生的微粒作为种子注入到流化床装置中，并在使其流化的同时喷洒提取物的溶液，从而将微粒生长至预定尺寸的颗粒或丸剂。 根据本发明，可以制备含有高浓度提取物的颗粒或丸剂。