公开(公告)号：WO2012101136A1

公开(公告)日：2012-08-02

申请号：PCT/EP2012/051070

申请日：2012-01-24

Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY ,  JOSHI, Lokesh ,  GERLACH, Jared ,  KILCOYNE, Michelle ,  FARRELL, Mark

Inventor： JOSHI, Lokesh ,  GERLACH, Jared ,  KILCOYNE, Michelle ,  FARRELL, Mark

IPC: C07K14/37 ,  C12N9/24

CPC classification number: C12N9/2402 ,  C12N9/2442 ,  C12Q1/34 ,  C12Y302/01096 ,  G01N2333/942

Abstract: The invention relates to an endo-β-N -acetylglucosaminidase enzyme isolatable from the fungus Trichoderma virde and to methods of producing the enzyme and uses of said enzyme.

Abstract translation: 本发明涉及可从真菌木霉分离的内切-β-N-乙酰氨基葡萄糖苷酶，以及生产酶的方法和所述酶的用途。

公开(公告)号：WO2014060436A1

公开(公告)日：2014-04-24

申请号：PCT/EP2013/071555

申请日：2013-10-15

Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY

Inventor： GLAVEY, Siobhan ,  JOSHI, Lokesh ,  O'DWYER, Michael

IPC: G01N33/574

CPC classification number: A61K31/7105 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57423 ,  G01N2333/91 ,  G01N2333/91148 ,  G01N2333/924 ,  G01N2400/00

Abstract: The present invention relates to the sialyltransferase ST3GAL6 for use as a biomarker for multiple myeloma, and especially as a marker for myelomas with inferior survival rates. The inventors have shown that glycosylation gene expression is dysregulated in Multiple Myeloma and that overexpression of the sialyltransferase ST3GAL6 is associated with inferior survival rates in patients.

Abstract translation: 本发明涉及用作多发性骨髓瘤生物标志物的唾液酸转移酶ST3GAL6，特别是作为存活率较低的骨髓瘤标志物。 本发明人已经表明糖基化基因表达在多发性骨髓瘤中失调，唾液酸转移酶ST3GAL6的过度表达与患者的较差存活率相关。

公开(公告)号：WO2014057129A1

公开(公告)日：2014-04-17

申请号：PCT/EP2013/071367

申请日：2013-10-11

Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY

Inventor： CUNNINGHAM, Stephen ,  STARR, Emily ,  SHAW, Iain ,  GLAVIN, John ,  KANE, Marian ,  JOSHI, Lokesh

IPC: C07K16/44 ,  C07K16/18 ,  G01N33/577

CPC classification number: G01N33/6842 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/23 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2400/02 ,  G01N2800/245

Abstract: The present invention relates to the provision of antibody fragments capable of binding selectively to the Gal-α-(1→3)-Gal epitope. The invention further relates to assay systems comprising these antibody fragments for use in testing transplantation tissue for possible rejection complications. This epitope is often found on porcine tissue destined for human transplantation. The epitope is also found on biopharmaceuticals and on some infectious agents and accordingly the invention also provides assay systems for these applications.

Abstract translation: 本发明涉及提供能够选择性结合Gal-α-（1→3）-Gal表位的抗体片段。 本发明还涉及包含用于测试移植组织以用于可能的排斥并发症的这些抗体片段的测定系统。 这种表位经常发现在用于人类移植的猪组织上。 表位也在生物药物和一些感染因子上发现，因此本发明还提供了用于这些应用的测定系统。