公开(公告)号：WO2014057129A1

公开(公告)日：2014-04-17

申请号：PCT/EP2013/071367

申请日：2013-10-11

Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY

Inventor： CUNNINGHAM, Stephen ,  STARR, Emily ,  SHAW, Iain ,  GLAVIN, John ,  KANE, Marian ,  JOSHI, Lokesh

IPC: C07K16/44 ,  C07K16/18 ,  G01N33/577

CPC classification number: G01N33/6842 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/23 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2400/02 ,  G01N2800/245

Abstract: The present invention relates to the provision of antibody fragments capable of binding selectively to the Gal-α-(1→3)-Gal epitope. The invention further relates to assay systems comprising these antibody fragments for use in testing transplantation tissue for possible rejection complications. This epitope is often found on porcine tissue destined for human transplantation. The epitope is also found on biopharmaceuticals and on some infectious agents and accordingly the invention also provides assay systems for these applications.

Abstract translation: 本发明涉及提供能够选择性结合Gal-α-（1→3）-Gal表位的抗体片段。 本发明还涉及包含用于测试移植组织以用于可能的排斥并发症的这些抗体片段的测定系统。 这种表位经常发现在用于人类移植的猪组织上。 表位也在生物药物和一些感染因子上发现，因此本发明还提供了用于这些应用的测定系统。