公开(公告)号：WO2017151062A1

公开(公告)日：2017-09-08

申请号：PCT/SG2017/050101

申请日：2017-03-03

Applicant: NATIONAL UNIVERSITY OF SINGAPORE

Inventor： YAN, Jie ,  WINARDHI, Ricksen Surya ,  MINGXI, Yao

IPC: G01Q60/24 ,  G01L5/00 ,  G01N21/64 ,  G01N23/20

CPC classification number: G01N27/745 ,  G01N21/648 ,  G01N33/6803 ,  G01N2500/04 ,  G01Q60/42

Abstract: A method of determining a presence of interaction between a substance molecule and a stretched substrate molecule, the method comprising the steps of: providing the stretched substrate molecule, such that a first contact point of the stretched substrate molecule and a second contact point of the stretched substrate molecule are separated at a displacement; contacting the stretched substrate molecule with a solution, wherein the solution comprises the substance molecule or is suspected to comprise the substance molecule; and detecting a change in the displacement between the first contact point and the second contact point of the stretched substrate molecule, wherein the change in the displacement between the first contact point and the second contact point indicates the presence of interaction between the substance molecule and the stretched substrate molecule.

Abstract translation: 一种确定物质分子与拉伸的底物分子之间相互作用的存在的方法，所述方法包括以下步骤：提供拉伸的底物分子，使得拉伸的底物分子的第一接触点 并且拉伸的底物分子的第二接触点在位移处分离; 使拉伸的底物分子与溶液接触，其中该溶液包含物质分子或被怀疑包含物质分子; 以及检测拉伸的基底分子的第一接触点和第二接触点之间的位移的变化，其中第一接触点和第二接触点之间的位移的变化指示物质分子与第二接触点之间的相互作用的存在 拉伸的底物分子。