公开(公告)号：WO2017097616A1

公开(公告)日：2017-06-15

申请号：PCT/EP2016/078973

申请日：2016-11-28

Applicant: NEURAVI LIMITED

Inventor： VALE, David ,  CASEY, Brendan ,  GILVARRY, Michael ,  MCARDLE, Kevin ,  HOLIAN, Maeve ,  HARDIMAN, David ,  KEANE, Alan ,  KING, Daniel ,  O'GORMAN, Jacqueline ,  BRADY, Eamon

IPC: A61B17/22 ,  A61M1/00

CPC classification number: A61B17/22031 ,  A61B17/22 ,  A61B17/29 ,  A61B17/3421 ,  A61B2017/22034 ,  A61B2017/22067 ,  A61B2017/22079 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2217/005 ,  A61M1/008

Abstract: A catheter has an expansile tip 901 that can be delivered in a constricted form. The increased tip diameter facilitates the aspiration and removal of large clot volumes by increasing the area of the catheter tip that applies aspiration to the clot. The tip 901 comprises a support frame which can be cut from a metal or polymer tube, covered with a thin polymer sleeve 909 containing highly elastic properties. This construction provides good pushability and high compressive resistance. The cut pattern can contain axial connections of the support frame 908 and ring members 906, which will provide a large level of axial support, lateral flexibility and hoop strength to withstand aspiration. The tip of the device can contain a section 907 proximal of the highly flexible area 905 that can expand to except clot. This potential to increase body diameter facilitates the retrieval of large volume clots while the construction of the catheter provides good column stiffness to avoid axial collapse and still maintain good flexibility.

Abstract translation: 导管具有可以收缩形式递送的可膨胀尖端901。 增加的尖端直径通过增加导管尖端的适用于凝块的抽吸区域来促进大量凝块体积的抽吸和去除。 尖端901包括支撑框架，该支撑框架可以由金属或聚合物管切割，覆盖有包含高度弹性特性的薄聚合物套筒909。 这种结构提供了良好的可推送性和高抗压性。 切割图案可以包含支撑框架908和环形构件906的轴向连接，这将提供大水平的轴向支撑，侧向柔性和箍强度以抵抗抽吸。 装置的尖端可以包含高度柔性区域905的近端部分907，其可以膨胀至除凝块外。 这种增加身体直径的可能性有助于取回大体积凝块，而导管的构造提供良好的柱刚度以避免轴向坍塌并仍保持良好的柔韧性。

公开(公告)号：WO2014140092A2

公开(公告)日：2014-09-18

申请号：PCT/EP2014/054828

申请日：2014-03-12

Applicant: NEURAVI LIMITED

Inventor： BRADY, Eamon ,  CASEY, Brendan ,  GILVARRY, Michael ,  HARDIMAN, David ,  VALE, David

IPC: A61B17/221

CPC classification number: A61B17/221 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61B2017/00942 ,  A61B2017/00951 ,  A61B2017/22034 ,  A61B2017/2212 ,  A61B2017/2217 ,  A61B2090/3966 ,  A61L31/022 ,  B05D1/322 ,  B05D3/12

Abstract: A clot retrieval device comprises an elongate shaft (104) and an expandable clot retrieval element (2101) on the shaft, the clot retrieval element comprising a framework formed from a substrate material such as Nitinol and having a plurality of struts (2105) and crowns (2102), at least some of the struts (2105) comprises at least one widened portion (2104) of the substrate material to provide enhanced radiopacity. The framework is coated with a radiopaque material such as gold. The device is rendered radiopaque with reduced damping effects.

Abstract translation: 凝块取出装置包括在轴上的细长轴（104）和可膨胀的凝块回缩元件（2101），所述凝块回收元件包括由诸如镍钛诺的基底材料形成的骨架，并且具有多个支柱（2105）和冠 （2102）中，所述支柱（2105）中的至少一些包括所述基底材料的至少一个加宽部分（2104），以提供增强的不透射线性。 该框架涂有不透射线的材料，例如金。 该设备被渲染为不透射线，减少了阻尼效应。

公开(公告)号：WO2014139845A1

公开(公告)日：2014-09-18

申请号：PCT/EP2014/054251

申请日：2014-03-05

Applicant: NEURAVI LIMITED

Inventor： BRADY, Eamon ,  CASEY, Brendan ,  GILVARRY, Michael ,  HARDIMAN, David ,  MCARDLE, Kevin ,  RAZAVI, Mahmood ,  VALE, David

IPC: A61B17/221 ,  A61B17/3207 ,  A61F2/01

CPC classification number: A61B17/221 ,  A61B17/12109 ,  A61B17/320725 ,  A61B2017/00358 ,  A61B2017/00778 ,  A61B2017/22034 ,  A61B2017/2212 ,  A61F2/013 ,  A61M29/00

Abstract: A clot retrieval device (1) for removing occlusive clot from a blood vessel, the device comprises an inner elongate body (3) having a collapsed delivery configuration and an expanded deployed configuration and an outer elongate body (2) at least partially overlying the inner elongate body (2).The outer elongate body (2) is expandable to a radial extent which is greater than the radial extent of the inner body (3) in the deployed configuration to define a clot reception space (11). The outer elongate body (2) comprises a distal end portion (24, 49) and the inner elongate body 3 comprises a main body portion (10) and a distal portion which extends in the deployed configuration towards the outer elongate body (2) to a greater extent than the main body portion. The distal portion (10) of the inner elongate member 3 and the distal end portion (24,49) of the outer elongate body (2) together define a three dimensional protective structure to substantially prevent distal egress of clot or clot fragments from the device.

Abstract translation: 一种用于从血管去除闭塞凝块的凝块取回装置（1），所述装置包括具有塌缩递送构型和扩张展开构型的内部细长体（3）和至少部分地覆盖内部细长体 细长体（2）。外部细长体（2）可扩张至径向范围，该径向程度大于展开构型中内体（3）的径向范围，以限定凝块接收空间（11）。 外部细长体（2）包括远端部分（24,49），并且内部细长体3包括主体部分（10）和远端部分，该远端部分在展开构造中朝着外部细长体（2）延伸到 比主体部分更大的程度。 内部细长构件3的远侧部分（10）和外部细长体（2）的远端部分（24,49）一起限定三维保护结构，以基本上防止凝块或凝块碎片从装置远端排出 。

公开(公告)号：WO2015189354A1

公开(公告)日：2015-12-17

申请号：PCT/EP2015/063104

申请日：2015-06-11

Applicant: NEURAVI LIMITED

Inventor： VALE, David ,  CASEY, Brendan ,  GILVARRY, Michael ,  MCARDLE, Kevin ,  HOLIAN, Maeve ,  HARDIMAN, David ,  KEANE, Alan ,  KING, Daniel

IPC: A61B17/22

CPC classification number: A61B17/22032 ,  A61B17/22 ,  A61B17/221 ,  A61B2017/00778 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2017/22079 ,  A61B2017/2215 ,  A61B2017/3435 ,  A61M1/0031 ,  A61M1/008 ,  A61M25/0082 ,  A61M2210/12

Abstract: A catheter 101 provides a proximal seal 102 against a guide catheter inner lumen 103 so that aspiration may be applied through a guide catheter 108 and thus take advantage of the large proximal lumen. The catheter 101 is a rapid exchange (RX) catheter with an exit port 105 that defines a transfer port for aspiration and provides a deliverability advantage of minimal frictional engagement with the guide catheter 108 proximal of the exit port 105. Aspiration can be applied to the lumen of the guide catheter 108 and is directed to and effective at the tip of the Rx aspiration catheter 101 due to the presence of flow a restrictor or seal 102 between the outer surface of the Rx aspiration catheter 101 and the inner guide catheter 108. This seals the lumen between the outside of the Rx aspiration catheter 101 and the inner surface of the guide catheter 03 and prevents backflow of blood into the tip of guide catheter 108 reducing the effectiveness of the aspiration. An expansile tip 112 of the Rx catheter 101 facilitates aspiration and retrieval of the clot 110 by expanding under load. The expansile tip 112 can also partially or fully occlude the vessel providing flow arrest and thereby improving aspiration effectiveness.

Abstract translation: 导管101提供靠近引导导管内腔103的近端密封件102，使得可以通过引导导管108施加抽吸，从而利用大的近端内腔。 导管101是具有限定用于抽吸的传送端口的出口105的快速交换（RX）导管，并提供与出口端口105附近的引导导管108的最小摩擦接合的可传送性优点。吸入可应用于 由于在Rx吸液导管101的外表面和内引导导管108之间存在限流器或密封件102，所以引导导管108的内腔被引导并且有效地在Rx抽吸导管101的尖端处。 密封Rx吸液导管101的外侧和引导导管03的内表面之间的内腔，并防止血液回流到引导导管108的顶端，从而降低吸气的效果。 Rx导管101的扩张尖端112有助于通过在负载下扩张来抽吸和取出凝块110。 膨胀尖端112还可以部分地或完全地封闭提供流动停止的血管，从而改善吸气效果。