公开(公告)号：WO2020198390A1

公开(公告)日：2020-10-01

申请号：PCT/US2020/024767

申请日：2020-03-25

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC.

Inventor： KOIDE, Shohei ,  MILLER, George ,  KOIDE, Akiko ,  CHEN, Linxiao ,  FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: C07K16/28 ,  A61K39/395 ,  C07K14/47 ,  G01N33/563 ,  G01N33/574 ,  A61P35/00

Abstract: Disclosed herein are anti-Galectin-9 antibodies and methods of using in modulating (e.g., increasing) immune responses in a subject, either taken alone or in combination with an immune checkpoint inhibitor, such as a PD-l inhibitor.

公开(公告)号：WO2020154548A2

公开(公告)日：2020-07-30

申请号：PCT/US2020/014858

申请日：2020-01-23

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC.

Inventor： KOIDE, Shohei ,  MILLER, George ,  KOIDE, Akiko ,  PANCHENKO, Tatyana ,  HATTORI, Takamitsu ,  FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61K39/395

Abstract: Disclosed herein are antibodies specific to a delta-1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti -Delta 1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.

公开(公告)号：WO2022109299A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/060140

申请日：2021-11-19

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC

Inventor： FILIPOVIC, Aleksandra ,  KOIDE, Akiko ,  KOIDE, Shohei ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61K39/395 ,  C07K16/28 ,  A61P37/06

Abstract: Disclosed herein are methods for treating solid tumors (e.g. , pancreatic adenocarcinoma (PDA), colorectal cancer (CRC), hepatocellular carcinoma (HCC)), or Cholangiocarcinoma and others), including, but not limited to, metastatic tumors, using an anti-Galectin-9 antibody.

公开(公告)号：WO2022109302A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/060143

申请日：2021-11-19

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC.

Inventor： KOIDE, Shohei ,  KOIDE, Akiko ,  FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61P35/00 ,  C07K16/28 ,  C07K16/06 ,  C07K16/22 ,  A61K2039/505 ,  C07K16/2851 ,  C07K16/30

Abstract: Combined therapy for a solid tumor, comprising an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g., G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.

公开(公告)号：WO2021022256A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/044777

申请日：2020-08-03

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC.

Inventor： KOIDE, Shohei ,  MILLER, George ,  KOIDE, Akiko ,  CHEN, Linxiao ,  FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61P35/00 ,  A61P37/02 ,  G01N33/68

Abstract: Combined therapy for a solid tumor, comprising an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g, G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.

公开(公告)号：WO2020154548A3

公开(公告)日：2020-07-30

申请号：PCT/US2020/014858

申请日：2020-01-23

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC.

Inventor： KOIDE, Shohei ,  MILLER, George ,  KOIDE, Akiko ,  PANCHENKO, Tatyana ,  HATTORI, Takamitsu ,  FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61K35/17 ,  A61P35/00 ,  A61P31/12 ,  A61P33/02 ,  A61K35/00

Abstract: Disclosed herein are antibodies specific to a delta-1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti -Delta 1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.

公开(公告)号：WO2020176856A1

公开(公告)日：2020-09-03

申请号：PCT/US2020/020387

申请日：2020-02-28

Applicant: PURETECH LYT, INC. ,  MONASH UNIVERSITY

Inventor： BOLEN, Joseph ,  BONNER, Daniel Kenneth ,  KARANAM, Ketki ,  PORTER, Christopher John ,  SIMPSON, Jamie ,  TREVASKIS, Natalie ,  ZHENG, Dan ,  LEONG, Nathania ,  SHARMA, Garima ,  MCINERNEY, Mitchell ,  QUACH, Tim ,  HAN, Sifei

IPC: A61K31/02 ,  A61K31/047 ,  A61K31/121 ,  A61K31/327 ,  C07C33/05 ,  C07C409/02

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：WO2022232653A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/027142

申请日：2022-04-29

Applicant: PURETECH LYT, INC.

Inventor： FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61K39/395 ,  A61P35/00 ,  A61K31/337 ,  A61K31/555 ,  A61K38/00

Abstract: Disclosed herein are combined therapies for treating solid tumors (e.g., pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CAA), renal cell carcinoma (RCC), urothelial, head and neck, breast cancer, lung cancer, or other gastrointestinal solid tumors), comprising an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g., G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.

公开(公告)号：WO2022232641A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/027127

申请日：2022-04-29

Applicant: PURETECH LYT, INC.

Inventor： FILIPOVIC, Aleksandra ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  A61P35/00

Abstract: Disclosed herein are methods for treating solid tumors (e.g., pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CAA), renal cell carcinoma (RCC), urothelial, head and neck, breast cancer, lung cancer, or other gastrointestinal solid tumors), using an anti-Galectin-9 antibody, e.g., as a monotherapy or as a combined therapy with an immune checkpoint inhibitor.

公开(公告)号：WO2021142336A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012796

申请日：2021-01-08

Applicant: PURETECH LYT, INC.

Inventor： BOLEN, Joseph ,  SHYAM, Rishab ,  BOGORAD, Roman ,  KRUMOVA, Katerina ,  PATTNI, Bhushan ,  PILLA, Nicholas ,  SINGH, Amit

IPC: A23C7/04 ,  A23C9/00

Abstract: Cargo-loaded vesicles and compositions comprising such vesicles for oral delivery are provided, wherein the vesicles comprise one or more components from milk purified vesicles. Methods for producing such cargo loaded vesicles are also provided.