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    STRUCTURE-FUNCTION RELATIONSHIPS IN THE DEVELOPMENT OF IMMUNOTHERAPEUTIC AGENTS
    1.
    发明申请
    STRUCTURE-FUNCTION RELATIONSHIPS IN THE DEVELOPMENT OF IMMUNOTHERAPEUTIC AGENTS 审中-公开

    公开(公告)号：WO2019118883A1

    公开(公告)日：2019-06-20

    申请号：PCT/US2018/065765

    申请日：2018-12-14

    Applicant: NORTHWESTERN UNIVERSITY

    Inventor： MIRKIN, Chad, A. ,  WANG, Shuya ,  ZHANG, Bin ,  SKAKUJ, Kacper

    IPC: A61K9/127 ,  A61K39/385 ,  A61K39/39 ,  A61K47/69

    Abstract: The present disclosure provides compositions and methods comprising spherical nucleic acid (SNA) components for use as immunotherapeutic agents. The disclosure provides a method comprising: treating a population of antigen presenting cells with a SNA comprising a nanoparticle, an antigen, and an adjuvant; and determining a time at which the population of antigen presenting cells presents a maximal signal that is indicative of antigen presentation by the antigen presenting cells and a time at which the population of antigen presenting cells presents a maximal co-stimulatory signal due to the adjuvant. The disclosure includes compositions that comprise a pharmaceutically acceptable carrier and a SNA of the disclosure, wherein the SNA comprises a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen that is associated with the surface of the SNA via a linker. The disclosure additionally includes articles of manufacture and kits.

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