公开(公告)号：WO2022234032A2

公开(公告)日：2022-11-10

申请号：PCT/EP2022/062183

申请日：2022-05-05

Applicant: NOVO NORDISK A/S

Inventor： BENGTSSON, Henrik ,  ARADÓTTIR, Tina, Björk ,  ENGELL, Sarah, Ellinor ,  MAHMOUDI, Zeinab ,  RYDE, Thomas, Emil ,  LIANG, Bo

IPC: G16H20/17 ,  A61B5/00 ,  A61M5/00 ,  G06N3/00 ,  G06N20/00 ,  G16H50/20 ,  G16H50/30 ,  A61B5/145 ,  A61M5/172 ,  A61B5/14532 ,  A61B5/7221 ,  A61B5/7267

Abstract: A method for estimating a fasting blood glucose (FBG) value for a subject, comprising the steps of obtaining a first data set representing a blood glucose history (BGH), obtaining a second data set representing a basal insulin injection history (IH) of the subject, and based on BGH and IH and using a mathematical model: calculating a predicted FBG for the time t+1, where t+1 is the current time. The method comprises the further steps of obtaining at time t+1 a current measured FBG from the subject, and based on the predicted FBG and the current measured FBG: calculating an updated estimated FBG.

公开(公告)号：WO2022234030A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/062181

申请日：2022-05-05

Applicant: NOVO NORDISK A/S

Inventor： BENGTSSON, Henrik ,  ARADÓTTIR, Tinna, Björk ,  ENGELL, Sarah, Ellinor ,  RYDE, Thomas, Emil

IPC: G16H20/10 ,  G16H20/17 ,  G16H50/20 ,  G16H50/50

Abstract: A method of estimating insulin on board (IOB) for a given glucose sensitive insulin (GSI) in a subject is provided. The method comprises the steps (i) for the given GSI, providing at least one rate constant (rc) as function of glucose concentration (rc(G)), (ii) providing for a period of time a continuous blood glucose log G(t) from the subject, (iii) providing for the period of time 5 an insulin dose log I(t) from the subject, (iv) based on rc(G) and G(t), calculating for each rc a rate constant as function of time (rc(t)), and (v) based on the at least one rc(t) and I(t) and using an estimating algorithm, calculating an estimated IOB for the subject.

公开(公告)号：WO2021037650A1

公开(公告)日：2021-03-04

申请号：PCT/EP2020/073293

申请日：2020-08-20

Applicant: NOVO NORDISK A/S

Inventor： BENGTSSON, Henrik ,  MAHMOUDI, Zeinab ,  ENGELL, Sarah, Ellinor

IPC: A61M39/02 ,  A61M39/10

Abstract: A patch device comprising a base portion having a mounting surface adapted to be mounted on a skin surface of a patient, and a combined catheter structure which in an operational state is adapted to protrude from the mounting surface, the combined catheter structure comprising a distal end adapted to be arranged in a patient's subcutaneous tissue. The combined catheter structure comprises a catheter lumen having a distal opening, and a sensor adapted to generate a signal indicative of a parameter value of a body fluid. An external fluid port in flow communication with the first catheter is adapted to receive an outlet of a drug delivery device such that in a mounted state a fluid communication is provided between the external fluid port and the patient subcutaneously tissue.