公开(公告)号：WO2022170174A1

公开(公告)日：2022-08-11

申请号：PCT/US2022/015460

申请日：2022-02-07

Applicant: NUTCRACKER THERAPEUTICS, INC.

Inventor： ELDRIDGE, Benjamin ,  SANII, Babak ,  KHANDROS, Igor ,  COSMAN, Jason

IPC: G01L9/00

Abstract: An apparatus includes a sensing region. A flexible membrane positioned in the sensing region defines a plane, a radial center, and a central axis extending perpendicularly relative to the plane at the radial center. The membrane deforms along the central axis and along a lateral dimension using at least a property of fluid (e.g., pressure or density) in the sensing region. The lateral dimension is transverse to the central axis. An optical feature changes a visual state in response to deformation of the membrane along the lateral dimension. A camera is positioned to view the optical feature and capture images of the optical feature.

公开(公告)号：WO2022144746A1

公开(公告)日：2022-07-07

申请号：PCT/IB2021/062331

申请日：2021-12-27

Applicant: NUTCRACKER THERAPEUTICS, INC.

Inventor： ELDRIDGE, Benjamin ,  KHANDROS, Igor

IPC: B65B3/00 ,  B65D21/02

Abstract: Filling systems and related container assemblies and methods are disclosed. In an implementation, a container assembly includes a container array, covers, a framework, and a fluidic network. The container array includes containers having distal ends and the covers are coupled to the respective distal ends of the containers. The framework is integral with: 1) the containers, 2) the covers and couples the containers together, or 3) both. The fluidic network includes fluidic channels that are defined by the framework and enable the containers to be filled in series or in parallel.

公开(公告)号：WO2021030271A2

公开(公告)日：2021-02-18

申请号：PCT/US2020/045625

申请日：2020-08-10

Applicant: NUTCRACKER THERAPEUTICS, INC.

Inventor： DEUTSCH, Samuel ,  ELDRIDGE, Benjamin ,  McKINLAY, Colin ,  WEN, Ximiao ,  NATH, Sangeeta ,  KHANDROS, Igor ,  EVANS, Robert

IPC: C12N15/10 ,  C12N15/1096 ,  B01J19/00 ,  C12P19/34 ,  A61P35/00 ,  B01L2400/0487 ,  B01L3/502707 ,  B01L3/502769 ,  C12M41/48 ,  C12N15/101 ,  C12N15/1013 ,  C12N15/1017 ,  G01N2021/0187 ,  G01N21/01

Abstract: Methods and apparatuses for making and using therapeutics, including in particular mRNA therapeutics, that separate double- stranded RNA from single- stranded RNA as part of a continuous flow. These methods and apparatuses may include formulation of an RNA therapeutic using a permeable insert integrated into a microfluidic path device. In particular, these methods and apparatuses may include formulation of an RNA therapeutic by removing dsRNA from a solution of RNA by within a microfluidic path device including a cellulose material.