公开(公告)号：WO2022147476A1

公开(公告)日：2022-07-07

申请号：PCT/US2021/073199

申请日：2021-12-30

Applicant: NUWELLIS, INC. ,  LERNER, David

Inventor： LERNER, David

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  A61M5/165

Abstract: A catheter may include a withdrawal lumen wall extending around a withdrawal lumen. The withdrawal lumen may have a withdrawal lumen profile. The catheter may include an infusion lumen wall coupled with the withdrawal lumen wall. The infusion lumen wall may extend around an infusion lumen. The infusion lumen may have an infusion lumen profile smaller than the withdrawal lumen profile. A flexible septum may extend between the withdrawal lumen and the infusion lumen. The flexible septum may isolate the withdrawal lumen from the infusion lumen. In another example, a blood filtration system may monitor blood flow velocity within vasculature. The blood filtration system may guide operation of a blood pump or a filtrate bump based on the blood flow velocity within the vasculature.

公开(公告)号：WO2023023583A1

公开(公告)日：2023-02-23

申请号：PCT/US2022/075121

申请日：2022-08-18

Applicant: NUWELLIS, INC. ,  LERNER, David ,  HASKVITZ, David, J. ,  BERG, Kalley, Francis ,  SANDOVAL, Steven, Daniel

Inventor： LERNER, David ,  HASKVITZ, David, J. ,  BERG, Kalley, Francis ,  SANDOVAL, Steven, Daniel

IPC: A61M1/34 ,  A61M1/36

Abstract: A blood filtration system can be used with an external infusion pump and can include, among other things, a withdrawal line, an infusion (return) line, a filter coupled between the withdrawal line and the infusion line, a controller, and a withdrawal pressure sensor and/or an infusion pressure sensor. The withdrawal pressure sensor can sense a withdrawal pressure signal indicative of a pressure in the withdrawal line. The infusion pressure sensor can be coupled to the infusion line to sense an infusion pressure signal indicative of a pressure in the infusion line. In various embodiments, the controller can detect an operational state of the external infusion pump by analyzing at least the withdrawal pressure signal and/or the infusion pressure signal.

公开(公告)号：WO2022147482A1

公开(公告)日：2022-07-07

申请号：PCT/US2021/073205

申请日：2021-12-30

Applicant: NUWELLIS, INC.

Inventor： LERNER, David

IPC: A61M1/00 ,  A61M1/34 ,  B01D61/00

Abstract: A blood filtration system may include one or more sensors. The sensors may determine physiological parameters, for instance one or more of venous oxygen saturation (Sv02) or hematocrit of a patient. The blood filtration system may include a controller. The controller may communicate with the one or more sensors. The controller may monitor the physiological parameters using the sensors. The controller may include a display module that generates content. A display may present the content. The content may include a diagnostic matrix having a diagnostic point. The display module may change the diagnostic point within the diagnostic matrix according to changes in the monitored physiological parameters.

公开(公告)号：WO2021203144A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/070352

申请日：2021-04-02

Applicant: NUWELLIS, INC.

Inventor： LERNER, David ,  HASKVITZ, David, J. ,  HART, Linda, Lee

IPC: A61M1/36 ,  A61M1/30 ,  A61M1/34

Abstract: A blood filtration system may reduce one or more plasma constituents in blood of a patient. The system may include one or more filters. A first filter may provide a filtrate fluid including the first set of filtered plasma constituents to a second filter. The second filter may reduce an amount of a second set of plasma constituents in the filtrate fluid provided by the first filter. The system may include one or more pumps. For instance, a blood pump may pressurize flow of blood into the first filter at a first pressure. A filtration pump may extract the filtrate fluid from the first filter. The filtration pump may pressurize flow of the filtrate fluid into the second filter at a second pressure. The second pressure may be higher than the first pressure.

公开(公告)号：WO2022187808A1

公开(公告)日：2022-09-09

申请号：PCT/US2022/070887

申请日：2022-03-01

Applicant: NUWELLIS, INC.

Inventor： LERNER, David ,  HASKVITZ, David J.

IPC: A61B5/022 ,  A61B5/15 ,  A61B17/135

Abstract: A blood filtration system may include a blood circuit. The blood filtration system may include an adjustable cuff configured to receive a portion of a limb of a patient. The cuff may selectively engage with the limb to apply an external force to the limb. Applying force to the limb with the cuff may inhibit flow of blood within the vasculature of the limb. The system may adjust the cuff to change the force applied to the limb, for example to correspondingly change flow of blood from the vasculature to the blood circuit. The blood filtration system may include a controller. The controller may communicate with the cuff. The controller may operate the cuff to adjust the force applied to the limb of the patient.

公开(公告)号：WO2017040218A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/048766

申请日：2016-08-25

Applicant: SUNSHINE HEART COMPANY PTY LTD. ,  OLSON, David ,  KNUTTILA, Aaron ,  TAS, Tolga ,  LERNER, David

Inventor： OLSON, David ,  KNUTTILA, Aaron ,  TAS, Tolga ,  LERNER, David

IPC: A61N1/36 ,  A61B5/0205 ,  A61N1/05 ,  A61N1/362 ,  A61N1/372 ,  A61M1/10 ,  A61M1/12

CPC classification number: A61N1/36114 ,  A61B5/0205 ,  A61M1/1055 ,  A61M1/1067 ,  A61M1/122 ,  A61N1/0556 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/3627 ,  A61N1/37288

Abstract: An example electrical stimulation system for use in combination with a non-pulsatile or low-pulsatile ventricular assist device and for restoration of autonomic balance by stimulating at least one nerve. The system includes a stimulation source including a controller configured to control delivery of electrical stimulation at a stimulation rate modeled to simulate a baroreceptor discharge related to an intrinsic heart rate, a lead operably coupled to the stimulation source, and at least one electrode operably coupled to the lead, wherein the at least one electrode is positionable in contact with or adjacent to the at least one nerve.

Abstract translation: 用于与非脉动或低搏动心室辅助装置组合使用的示例性电刺激系统，以及通过刺激至少一个神经来恢复自主平衡。 所述系统包括刺激源，所述刺激源包括控制器，所述控制器被配置成以刺激速率控制电刺激的传递，所述刺激速率被建模为模拟与内在心率相关的压力感受器放电，可操作地耦合到所述刺激源的引线，以及至少一个电极， 所述引线，其中所述至少一个电极可定位成与所述至少一个神经接触或相邻。

公开(公告)号：WO2002086583A1

公开(公告)日：2002-10-31

申请号：PCT/US2002/008120

申请日：2002-03-15

Applicant: ONIX MICROSYSTEMS ,  BEHIN, Behrang ,  CHAPARALA, Murali ,  CONANT, Robert ,  DANEMAN, Michael ,  HORSLEY, David ,  KIANG, Meng-Hsiung ,  LERNER, David ,  PANNU, Satinderpall ,  WYCZALKOWSKI, Matthew ,  ZALEWSKI, Gary

Inventor： BEHIN, Behrang ,  CHAPARALA, Murali ,  CONANT, Robert ,  DANEMAN, Michael ,  HORSLEY, David ,  KIANG, Meng-Hsiung ,  LERNER, David ,  PANNU, Satinderpall ,  WYCZALKOWSKI, Matthew ,  ZALEWSKI, Gary

IPC: G02B26/00

CPC classification number: G02B6/3556 ,  G02B6/3512 ,  G02B6/3588

Abstract: A beam steering module (2302) comprised of a mirror stack array (2304, 2308) in close proximity to a collimator array (2306) controllably steers photons along two axis and in a direction substantially less than 90 degrees to the collimator orientation. Several configurations of the module are described using single (900) and double (800) axis mirror rotation and relay optics (120, 216,226). Optical telecommunications switches (2300) are shown using modules coupled to each other along flat and curved surfaces, with and without use of fold mirror (2310) and enabling a plurality of configuration options including photodetector optical power monitoring schemes that require no external power taps.

Abstract translation: 由靠近准直器阵列（2306）的反射镜阵列（2304,2308）组成的光束转向模块（2302）可控制地沿着两个轴线并且沿着与准直器取向基本上小于90度的方向导引光子。 使用单（900）和双（800）轴反射镜旋转和中继光学器件（120,216,226）描述了该模块的几种配置。 光通信开关（2300）被示出为使用具有和不使用折叠镜（2310）的平面和弯曲表面彼此耦合的模块，并且实现了多个配置选项，包括不需要外部电源抽头的光电检测器光功率监控方案。