公开(公告)号：WO2022115599A1

公开(公告)日：2022-06-02

申请号：PCT/US2021/060815

申请日：2021-11-24

申请人： OAK CREST INSTITUTE OF SCIENCE

发明人： BAUM, Marc M. ,  ANTON, Peter A. ,  GUNAWARDANA, Manjula ,  MOSS, John A.

IPC分类号： A61F2/02 ,  A61K9/00 ,  A61M25/00 ,  A61M37/00

摘要： Provided herein are drug delivery devices, comprising a scaffold comprising one or more biocompatible materials, one or more chambers containing a plurality of cells, one or more membranes, and one or more nutrient supplementation systems. Also provided are methods of treating or preventing diseases and disorders in a subject in need thereof, comprising administering to the subject the drug delivery devices disclosed herein, and methods of making the drug delivery devices disclosed herein.

公开(公告)号：WO2017161136A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022743

申请日：2017-03-16

申请人： OAK CREST INSTITUTE OF SCIENCE

发明人： BAUM, Marc M. ,  GUNAWARDANA, Manjula ,  MOSS, John A.

IPC分类号： A61K31/395 ,  A61K31/675 ,  A61K47/12

CPC分类号： A61K31/675 ,  A61K9/0036 ,  A61K9/2013

摘要： The disclosure provides a composition comprising a drug that is the salt of one or more basic nitrogen atoms targeted for vaginal delivery and one or more acidic excipients. The disclosure further provides a method comprising administering the composition to the vagina of a subject, and a kit comprising a container comprising the composition and instructions for the use thereof.

摘要翻译： 本公开提供了包含药物的组合物，所述药物是一种或多种靶向用于阴道递送的碱性氮原子的盐和一种或多种酸性赋形剂。 本公开内容进一步提供了一种方法，包括将组合物施用于受试者的阴道，以及包含容器的试剂盒，所述容器包含所述组合物和使用说明书。

公开(公告)号：WO2016149561A1

公开(公告)日：2016-09-22

申请号：PCT/US2016/022980

申请日：2016-03-17

申请人： OAK CREST INSTITUTE OF SCIENCE

发明人： BAUM, Marc M. ,  GUNAWARDANA, Manjula ,  MOSS, John A. ,  SMITH, Thomas J.

IPC分类号： A61K9/22 ,  A61K9/30 ,  A61P31/12

CPC分类号： A61K31/675 ,  A61K9/0021 ,  A61K9/0024 ,  A61K31/215 ,  A61K31/513 ,  A61K31/522 ,  A61K38/09 ,  A61K38/26 ,  A61K38/31 ,  A61K45/06 ,  A61M37/0069

摘要： In various embodiments, the invention discloses devices, systems and methods for achieving sustained release agent delivery. The methods generally include administering a sustained release agent delivery system to a mammalian organism in need of such treatment at an 5 area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. In various embodiments, the device consists of a perforated tube of agent-impermeable material (e.g., silicone) containing a core or reservoir of effective agent, with the tube encased in an agent-permeable material that allows the effective agent to pass through the perforations.

摘要翻译： 在各种实施方案中，本发明公开了用于实现持续释放剂递送的装置，系统和方法。 所述方法通常包括向需要这种治疗的哺乳动物生物体施用持续释放剂递送系统，其中需要释放有效药剂并允许有效药物以受控的方式通过该装置。 在各种实施例中，该装置由含有有效试剂的芯或储存器的不透液剂的穿孔管（例如，硅树脂）组成，该管包裹在可渗透材料的试剂中，其允许有效试剂通过穿孔 。