公开(公告)号：WO2017087904A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062946

申请日：2016-11-18

Applicant: ORGANOVO, INC.

Inventor： RAPOPORT, Harry Scott ,  BOZEK, Emily ,  BRUGNANO, Jamie ,  JOSHI, Vaidehi S. ,  PENTONEY, Steve ,  SCOTT, Gina

IPC: B29C67/00 ,  C09D11/04 ,  C09D11/102 ,  C12M1/00 ,  B41J2/015 ,  G06F19/00

CPC classification number: C09D11/38 ,  C09D11/03 ,  C09D11/04 ,  C09D11/102 ,  C12M33/00 ,  G06F19/00

Abstract: Disclosed are bioprinters for rapidly fabricating biological tubes comprising extruding a bio-ink filament onto a rotating mandrel. Also disclosed are methods of rapidly fabricating biological tubes comprising extruding a bio-ink filament onto a rotating mandrel, maturing the deposited bio-ink filament, and removing the biological tube from the mandrel. Also disclosed are methods of fabricating a multilayered biological tube. Also disclosed are engineered biological tubes prepared using the disclosed methods.

Abstract translation: 公开了用于快速制造生物管的生物打印机，其包括将生物墨水丝挤出到旋转心轴上。 还公开了快速制造生物管的方法，包括将生物墨水丝挤出到旋转的心轴上，使沉积的生物墨水丝成熟，并从心轴上取下生物管。 还公开了制造多层生物管的方法。 还公开了使用所公开的方法制备的工程生物学试管。