公开(公告)号：WO2018098223A1

公开(公告)日：2018-05-31

申请号：PCT/US2017/062941

申请日：2017-11-22

申请人： OSIRIS THERAPEUTICS, INC.

发明人： SINCLAIR, Steven Michael ,  DUAN-ARNOLD, Yi ,  GYURDIEVA, Alexandra ,  JOHNSON, Amy Elizabeth ,  UVEGES, Thomas Edward ,  GERAGHTY, Sandra D. ,  KUANG, Jin-Qiang ,  DANILKOVITCH, Alla

IPC分类号： B65D81/18 ,  A61B17/06 ,  C12M3/00

CPC分类号： A01N1/0273 ,  A61B17/06 ,  B65D25/10 ,  B65D51/18 ,  B65D77/046 ,  B65D81/027 ,  B65D2251/0018 ,  B65D2251/0081 ,  C12M45/22

摘要： A sealable tray system for sealing a product in a transport-ready position. The sealable tray system has an insert, a first lid, an outer basin, and a second lid. The insert has a well portion with a base surface that extends upwardly to support the product. The insert also has a flange portion that extends outwardly from the well portion and is sealingly engaged by the first lid. The outer basin receives the insert in the transport-ready position, and the second lid engages a top surface of the outer basin. Methods of sealing a product in a transport-ready position are also disclosed.

公开(公告)号：WO2015171142A1

公开(公告)日：2015-11-12

申请号：PCT/US2014/037201

申请日：2014-05-07

申请人： OSIRIS THERAPEUTICS, INC.

发明人： JANSEN, Timothy ,  TOM, Samson ,  DANILKOVITCH, Alla ,  YOO, Dana ,  ZERHUSEN, Jaime ,  TODD, Gabriele Putz ,  JOHNSON, Amy Elizabeth

IPC分类号： A61K35/50

CPC分类号： A61K35/50 ,  A61K45/06

摘要： This invention provides a therapeutic placental composition comprising placental cells and other placental components derived from placental tissue. A cryopreserved placental composition is also provided. The placental compositions can be used to stimulate and promote angiogenesis, reduce inflammation, and to reduce scar formation, among others. The placental tissue can optionally be an amnion, chorion, a trophoblast-depleted chorion, umbilical cord, Wharton's jelly, placental cotyledon, and/or maternal decidua. The placental composition of the present invention is useful in treating a patient with a tissue injury (e.g., wound or burn) by applying the placental composition to the injury or in close proximity. Placental compositions may also be used to promote or increase regeneration of tissue. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

摘要翻译： 本发明提供包含胎盘细胞和源自胎盘组织的其它胎盘成分的治疗性胎盘组合物。 还提供了一种冷冻保存的胎盘组合物。 胎盘组合物可用于刺激和促进血管生成，减少炎症，并减少瘢痕形成等。 胎盘组织可以任选地是羊膜，绒毛膜，滋养层细胞的绒毛膜，脐带，沃顿的果冻，胎盘子叶和/或母体的蜕膜。 本发明的胎盘组合物可用于通过将胎盘组合物施用于损伤或紧邻来治疗患有组织损伤（例如伤口或烧伤）的患者。 胎盘组合物也可用于促进或增加组织再生。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。