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    IMMUNOCOMPATIBLE AMNIOTIC MEMBRANE PRODUCTS
    1.
    发明申请
    IMMUNOCOMPATIBLE AMNIOTIC MEMBRANE PRODUCTS 审中-公开
    免疫调节膜产品

    公开(公告)号：WO2015171144A1

    公开(公告)日：2015-11-12

    申请号：PCT/US2014/037208

    申请日：2014-05-07

    申请人： OSIRIS THERAPEUTICS, INC.

    发明人： TOM, Samson ,  DANILKOVITCH, Alla ,  YOO, Dana ,  JANSEN, Timothy ,  KUANG, Jin-Qiang ,  MARCONI, Jennifer Michelle

    IPC分类号： A61K35/50

    CPC分类号： A61K35/50 ,  A61K35/28 ,  A61K35/33 ,  A61L27/3604 ,  A61L27/3691 ,  A61L27/54 ,  C12N5/0605

    摘要： Provided herein is a placental membrane product comprising an immunocompatible amniotic membrane. Such placental membrane products can be cryopreserved and contain therapeutic factors and viable cells after thawing. The placental membrane products are useful in wound healing and tissue repair/regeneration as they are capable of promoting angiogenesis, reducing inflammation, inhibiting proteases and free radical oxidation, reducing scar formation, and other methods that promote healing. The present technology relates to products to protect injured or damaged tissue, or as a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, and/or to promote healing or growth of tissue. The field also relates to methods of manufacturing and methods of use of such membrane-derived products.

    摘要翻译： 本文提供了包含免疫兼容的羊膜的胎盘膜产品。 这样的胎盘膜产品可以在冷冻保存后含有治疗因子和解冻后的活细胞。 胎盘膜产品可用于伤口愈合和组织修复/再生，因为它们能够促进血管生成，减少炎症，抑制蛋白酶和自由基氧化，减少瘢痕形成以及促进愈合的其它方法。 本技术涉及用于保护受伤或损坏的组织的产品，或作为防止粘连的覆盖物，排除细菌，抑制细菌活性和/或促进组织愈合或生长的产品。 该领域还涉及这种膜衍生产品的制造方法和使用方法。

    VIABLE LYOPHILIZED COMPOSITIONS DERIVED FROM HUMAN TISSUES AND METHODS OF MAKING THE SAME
    3.
    发明申请
    VIABLE LYOPHILIZED COMPOSITIONS DERIVED FROM HUMAN TISSUES AND METHODS OF MAKING THE SAME 审中-公开
    来自人体组织的可渗透冻干组合物及其制备方法

    公开(公告)号：WO2017223520A1

    公开(公告)日：2017-12-28

    申请号：PCT/US2017/039123

    申请日：2017-06-23

    申请人： OSIRIS THERAPEUTICS, INC.

    发明人： SINCLAIR, Steven Michael ,  DANILKOVITCH, Alla ,  SATHYAMOORTHY, Malathi ,  KUANG, Jin-Qiang ,  DHALL, Sandeep ,  MELCHIORRI, Anthony John

    IPC分类号： A01N1/02 ,  A61F2/10 ,  A61F2/28 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54

    摘要： Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.

    摘要翻译： 公开了冻干组织样品的方法，包括获得组织样品，使组织样品与冻干保护剂溶液接触，冷冻组织样品，冷冻后进行组织样品的第一干燥步骤， 在第一干燥步骤之后的组织样本的第二干燥步骤。 公开了使用冻干组织样品的公开方法制备的冻干组织，包括获得组织样品，使组织样品与冻干保护剂溶液接触，冷冻组织样品，冷冻后进行组织样品的第一干燥步骤， 在第一干燥步骤之后干燥组织样品的步骤。 公开了治疗伤口或组织缺损的方法，包括将重建的冻干组织施用于伤口或组织缺陷。