公开(公告)号：WO2021252644A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036638

申请日：2021-06-09

申请人： PARDES BIOSCIENCES, INC.

发明人： ARNOLD, Lee D. ,  JENNINGS, Andy ,  KEUNG, Walter

IPC分类号： C07D207/263 ,  C07D235/24 ,  C07D403/12 ,  C07D471/04 ,  C07D417/14 ,  C07D403/14 ,  C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D487/10 ,  C07D471/10 ,  C07D413/14 ,  C07D491/107 ,  C07D513/04 ,  C07D209/34 ,  C07F7/08 ,  C07D521/00 ,  A61P31/12 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/438 ,  A61K31/45 ,  A61K31/454 ,  C07K14/165 ,  C12N9/50 ,  C12N9/99 ,  A61K31/00 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4545 ,  A61K45/06 ,  A61P31/14 ,  C07D207/26 ,  C07D211/40 ,  C07D487/04 ,  C07D487/18 ,  C07D491/10 ,  C07F7/0807 ,  C07F7/0812 ,  C07F7/0816 ,  C07K14/005 ,  C12N2770/20022 ,  C12N9/506 ,  C12Y304/22069

摘要： The disclosure provides compounds of formula II with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Formula II

公开(公告)号：WO2023044509A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/076742

申请日：2022-09-20

申请人： PARDES BIOSCIENCES, INC.

发明人： ARNOLD, Lee D. ,  KEUNG, Walter ,  REDDY, Jayachandra P.

IPC分类号： C07D401/12 ,  A61P31/14 ,  A61K38/05

摘要： The disclosure provides a process for the preparation of compounds with nitrile warheads, e.g., a compound of Formula I, contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：WO2023044171A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/044163

申请日：2022-09-20

申请人： PARDES BIOSCIENCES, INC.

发明人： ARNOLD, Lee D. ,  KEUNG, Walter ,  KUMAR, Dange Vijay

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/20 ,  A61P31/22 ,  C07D213/57 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12

摘要： The disclosure provides compounds with nitrile warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with nitrile warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：WO2023023631A1

公开(公告)日：2023-02-23

申请号：PCT/US2022/075185

申请日：2022-08-18

申请人： PARDES BIOSCIENCES, INC.

发明人： BUZARD, Daniel, J. ,  KEUNG, Walter ,  KUMAR, Dange, Vijay ,  VERNER, Erik ,  ARNOLD, Lee, D.

IPC分类号： C07K5/062 ,  C07K5/072 ,  C07K5/078 ,  A61P31/12 ,  A61P31/14 ,  A61K31/403 ,  A61K31/438 ,  A61K31/45 ,  A61K31/4523 ,  A61K31/497

摘要： The disclosure provides compounds with nitrile warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with nitrile warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：WO2021212039A1

公开(公告)日：2021-10-21

申请号：PCT/US2021/027780

申请日：2021-04-16

申请人： PARDES BIOSCIENCES, INC.

发明人： ARNOLD, Lee D. ,  LOPATIN, Uri ,  KEUNG, Walter

IPC分类号： A61K31/496 ,  A61K31/53 ,  A61P31/12

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.