公开(公告)号：WO2021252644A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036638

申请日：2021-06-09

申请人： PARDES BIOSCIENCES, INC.

发明人： ARNOLD, Lee D. ,  JENNINGS, Andy ,  KEUNG, Walter

IPC分类号： C07D207/263 ,  C07D235/24 ,  C07D403/12 ,  C07D471/04 ,  C07D417/14 ,  C07D403/14 ,  C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D487/10 ,  C07D471/10 ,  C07D413/14 ,  C07D491/107 ,  C07D513/04 ,  C07D209/34 ,  C07F7/08 ,  C07D521/00 ,  A61P31/12 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/438 ,  A61K31/45 ,  A61K31/454 ,  C07K14/165 ,  C12N9/50 ,  C12N9/99 ,  A61K31/00 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4545 ,  A61K45/06 ,  A61P31/14 ,  C07D207/26 ,  C07D211/40 ,  C07D487/04 ,  C07D487/18 ,  C07D491/10 ,  C07F7/0807 ,  C07F7/0812 ,  C07F7/0816 ,  C07K14/005 ,  C12N2770/20022 ,  C12N9/506 ,  C12Y304/22069

摘要： The disclosure provides compounds of formula II with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Formula II

公开(公告)号：WO2021141692A2

公开(公告)日：2021-07-15

申请号：PCT/US2020/061696

申请日：2020-11-21

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： FLYNN, Michael, J. ,  ELOWITZ, Michael, B. ,  HORI, Acacia ,  GRADINARU, Viviana

IPC分类号： C12N15/63 ,  C12N15/62 ,  C07K14/435 ,  C12N9/48 ,  A61K48/00 ,  A61P25/28 ,  A61K38/00 ,  C07K14/005 ,  C07K14/4702 ,  C07K2319/60 ,  C07K2319/71 ,  C07K2319/95 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2770/34022 ,  C12N9/506 ,  C12Y304/22044

摘要： Disclosed herein include methods, compositions, and kits suitable for robust and tunable control of payload gene expression. Some embodiments provide rationally designed circuits, including miRNA-level and/or protein-level incoherent feed-forward loop circuits, that maintain the expression of a payload at an efficacious level. The circuit can comprise a promoter operably linked to a polynucleotide encoding a fusion protein comprising a payload protein, a protease, and one or more self-cleaving peptide sequences. The payload protein can comprise a degron and a cut site the protease is capable of cutting to expose the degron. The circuit can comprise a promoter operably linked to a polynucleotide comprising a payload gene, a silencer effector cassette, and one or more silencer effector binding sequences.