公开(公告)号：WO2019220296A1

公开(公告)日：2019-11-21

申请号：PCT/IB2019/053905

申请日：2019-05-10

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： KORNILOVA, Anna ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa

IPC: H01J27/26 ,  H01J49/16

Abstract: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.

公开(公告)号：WO2019092640A1

公开(公告)日：2019-05-16

申请号：PCT/IB2018/058793

申请日：2018-11-08

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： KAUSHAL, Frenny ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa ,  JOLLIFFE, Charles

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/04

Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.

公开(公告)号：WO2019220295A1

公开(公告)日：2019-11-21

申请号：PCT/IB2019/053904

申请日：2019-05-10

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： SARRAFZADEH, Mehrnaz ,  JAVAHERY, Gholamreza ,  JOLLIFFE, Charles ,  COUSINS, Lisa

IPC: H05H1/24 ,  G01N21/73 ,  H05H1/42

Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.

公开(公告)号：WO2019202518A1

公开(公告)日：2019-10-24

申请号：PCT/IB2019/053154

申请日：2019-04-16

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： GAMBLE, Heather ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa ,  JOLLIFFE, Charles

IPC: H01J49/08 ,  H01J49/42

Abstract: Certain configurations of a mass analyzer comprising two chambers for ionizing species to form ions and/or introduce a reaction gas to assist in ionization are described. In some instances, a first chamber may receive electrons to permit electron bombardment of a first gas. A second chamber can receive a second gas and the ions from the first chamber to permit the ions and second gas to interact. The first gas or the second gas or both may include analyte.

公开(公告)号：WO2019064285A1

公开(公告)日：2019-04-04

申请号：PCT/IB2018/057599

申请日：2018-09-29

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC

Inventor： GAMBLE, Heather ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa ,  JOLLIFFE, Charles

IPC: H01J49/10 ,  H01J27/02 ,  H01J49/26

Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.

公开(公告)号：WO2019211788A1

公开(公告)日：2019-11-07

申请号：PCT/IB2019/053594

申请日：2019-05-02

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： KAUSHAL, Frenny ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa ,  JOLLIFFE, Charles

IPC: H01J49/10 ,  H01J49/04

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulìzing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APR source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyzer.