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    PLEURAL EFFUSION TREATMENT DEVICE, METHOD AND MATERIAL
    1.
    发明申请
    PLEURAL EFFUSION TREATMENT DEVICE, METHOD AND MATERIAL 审中-公开
    PLEURAL EFFUSION处理装置，方法和材料

    公开(公告)号：WO2006014567A2

    公开(公告)日：2006-02-09

    申请号：PCT/US2005024172

    申请日：2005-07-08

    Applicant: PNEUMRX INC ,  MCGURK ERIN ,  DIECK RONALD ,  WARTCHOW CHARLES ,  GONG GLEN ,  BALCETA JOBERT

    Inventor： MCGURK ERIN ,  DIECK RONALD ,  WARTCHOW CHARLES ,  GONG GLEN ,  BALCETA JOBERT

    IPC: A61B17/08

    CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0074 ,  A61M31/00 ,  A61M2025/0073

    Abstract: The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.

    Abstract translation: 本发明公开了一种治疗患者胸腔积液的方法，包括将粘合剂材料经皮递送至患者的胸膜腔。 用于实施本发明方法的任何实施方案的合适的粘合剂材料可以选自水凝胶，胶原，聚（乳酸），聚（乙交酯），氰基丙烯酸酯，戊二醛，PEG，蛋白质和多糖及衍生物 它们。 本发明还公开了一种胸腔积液治疗装置，其包括适于粘附限定胸膜腔的胸膜的粘合剂材料和适于将粘合剂材料输送到胸膜腔的胸膜空间进入构件。

    TARGETING DAMAGED LUNG TISSUE
    2.
    发明申请
    TARGETING DAMAGED LUNG TISSUE 审中-公开
    靶向破坏性肺组织

    公开(公告)号：WO2006009699A3

    公开(公告)日：2007-03-22

    申请号：PCT/US2005020993

    申请日：2005-06-13

    Applicant: PNEUMRX INC ,  GONG GLEN ,  DIECK RONALD

    Inventor： GONG GLEN ,  DIECK RONALD

    IPC: A61K38/00 ,  A61K49/00 ,  C12N9/66

    CPC classification number: A61K49/0008

    Abstract: The present invention relates to methods and compositions for targeting damaged lung tissue. Compositions provided feature a targeting moiety coupled to one or more other moieties, including, for example, a cross-linkable moiety, an imaging moiety, and/or one or more other targeting moieties. The methods and compositions of the invention find use, for example, in detecting and treating a pulmonary condition such as emphysema.

    Abstract translation: 本发明涉及用于靶向损伤的肺组织的方法和组合物。 提供的组合物具有与一个或多个其它部分偶联的靶向部分，包括例如可交联部分，成像部分和/或一个或多个其它靶向部分。 本发明的方法和组合物可用于例如检测和治疗诸如肺气肿的肺部疾病。

    LUNG DEVICE WITH SEALING FEATURES
    4.
    发明申请
    LUNG DEVICE WITH SEALING FEATURES 审中-公开

    公开(公告)号：WO2006014568A3

    公开(公告)日：2007-12-13

    申请号：PCT/US2005024173

    申请日：2005-07-08

    Applicant: PNEUMRX INC ,  MCGURK ERIN ,  MATHIS MARK ,  DIECK RONALD ,  WARTCHOW CHARLES

    Inventor： MCGURK ERIN ,  MATHIS MARK ,  DIECK RONALD ,  WARTCHOW CHARLES

    IPC: A61M5/178

    CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/0065 ,  A61B2017/00654

    Abstract: This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.

    LUNG DEVICE WITH SEALING FEATURES
    5.
    发明申请
    LUNG DEVICE WITH SEALING FEATURES 审中-公开
    具有密封特征的肺部装置

    公开(公告)号：WO2007008229A3

    公开(公告)日：2007-11-22

    申请号：PCT/US2005030717

    申请日：2005-08-30

    Applicant: PNEUMRX INC ,  MCGURK ERIN ,  MATHIS MARK ,  DIECK RONALD ,  WARTCHOW CHARLES

    Inventor： MCGURK ERIN ,  MATHIS MARK ,  DIECK RONALD ,  WARTCHOW CHARLES

    IPC: A61B1/012 ,  A61B1/267

    CPC classification number: A61B17/00491 ,  A61B17/0057 ,  A61B17/32002 ,  A61B17/34 ,  A61B17/3415 ,  A61B2017/00278 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/00641 ,  A61B2017/00809

    Abstract: This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.

    Abstract translation: 本发明一般涉及用于安全地执行经胸腔手术的肺部装置的设计。 特别地，本发明提供了使用这些装置以最小的导致气胸或血胸风险的胸腔进入的装置和方法。 更具体地，本发明能够使用大孔器械诊断和治疗进入胸腔。 本发明还提供了一种诊断和治疗方法，该方法使用能够在装置取出时密封伤口的装置。 本发明包括一种装置，其包括适于通过进入孔与受试者的组织接触的细长体和密封剂递送元件。 本发明还包括在受试者中进行组织治疗或诊断的方法。

    LUNG DEVICE WITH SEALING FEATURES
    6.
    发明申请
    LUNG DEVICE WITH SEALING FEATURES 审中-公开
    带密封功能的肺部装置

    公开(公告)号：WO2007008229A8

    公开(公告)日：2007-05-18

    申请号：PCT/US2005030717

    申请日：2005-08-30

    Applicant: PNEUMRX INC ,  MCGURK ERIN ,  MATHIS MARK ,  DIECK RONALD ,  WARTCHOW CHARLES

    Inventor： MCGURK ERIN ,  MATHIS MARK ,  DIECK RONALD ,  WARTCHOW CHARLES

    IPC: A61B17/08

    CPC classification number: A61B17/00491 ,  A61B17/0057 ,  A61B17/32002 ,  A61B17/34 ,  A61B17/3415 ,  A61B2017/00278 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/00641 ,  A61B2017/00809

    Abstract: This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.

    Abstract translation: 本发明一般涉及用于安全执行经胸手术的肺装置的设计。 具体而言，本发明提供了使用这些装置进入胸腔的装置和方法，其造成气胸或血胸的风险最小。 更具体地说，本发明能够使用大口径器械诊断和治疗进入胸腔。 本发明还提供了一种使用能够在器械撤回时密封伤口的装置的诊断和治疗程序的方法。 本发明包括一种装置，该装置包括适于通过进入孔与受试者的组织接触的细长主体，以及密封剂输送元件。 本发明还包括在受试者中进行组织治疗或诊断的方法。

    BIOCOMPATIBLE PHASE INVERTABLE PROTEINACEOUS COMPOSTIONS AND METHODS FOR MAKING AND USING THE SAME
    7.
    发明申请
    BIOCOMPATIBLE PHASE INVERTABLE PROTEINACEOUS COMPOSTIONS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
    生物相容性不可逆蛋白质组合物及其制备和使用方法

    公开(公告)号：WO2004012678A3

    公开(公告)日：2004-06-24

    申请号：PCT/US0324457

    申请日：2003-08-05

    Applicant: MATRIX MEDICAL LLC ,  SCHANKERELI KEMAL ,  DIECK RONALD

    Inventor： SCHANKERELI KEMAL ,  DIECK RONALD

    IPC: A61L24/00 ,  A61L24/10 ,  A61L29/04 ,  A61L31/04 ,  A61F13/00 ,  A61F2/00

    CPC classification number: C09J189/00 ,  A61K9/0024 ,  A61K47/42 ,  A61L24/0021 ,  A61L24/10 ,  A61L29/044 ,  A61L31/043

    Abstract: Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a pasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross-linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

    Abstract translation: 提供了生物相容性相可逆蛋白质组合物及其制备和使用方法。 通过组合蛋白质底物和交联剂制备目标相可逆组合物。 蛋白质底物包括一种或多种蛋白质和粘合改性剂，并且还可以包括以下的一种或多种：增塑剂，碳水化合物或其它改性剂。 在某些实施方案中，交联剂是经热处理的二醛，例如经热处理的戊二醛。 还提供了用于制备主题组合物的试剂盒。 主题组合物，试剂盒和系统可用于各种不同的应用。

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