公开(公告)号：WO2010135352A1

公开(公告)日：2010-11-25

申请号：PCT/US2010/035297

申请日：2010-05-18

Applicant: PNEUMRX, INC. ,  MATHIS, Mark, L. ,  WU, Patrick ,  LEHRBERG, David ,  VASQUEZ, Jaime ,  MCGURK, Erin ,  DIECK, Ronald ,  STEIN, Andrew

Inventor： MATHIS, Mark, L. ,  WU, Patrick ,  LEHRBERG, David ,  VASQUEZ, Jaime ,  MCGURK, Erin ,  DIECK, Ronald ,  STEIN, Andrew

IPC: A61F2/04

CPC classification number: A61B17/12104 ,  A61B1/2676 ,  A61B17/10 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2002/043

Abstract: Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

Abstract translation: 细长的植入物结构可被引入到目标气道轴向区域的气道系统中，经常在气道内长时间施加横向弯曲和/或压缩力对肺组织。 植入物的结构或特征可以抑制组织反应，否则可能会使装置的部分最终穿过气道的壁。 这些装置可以增强在周围气道腔壁的组织上横向承受的面积。 实施例可以具有增加与气道的装置摩擦的特征，以允许装置在装置展开时夹紧周围的气道。 可能在肺内的装置周围引入适当的粘合剂。 亲水性材料可能抑制生物膜形成，或诱导一些组织向内生长（刺激组织生长）的特征可以增强植入装置的支持。

公开(公告)号：WO2006014568A2

公开(公告)日：2006-02-09

申请号：PCT/US2005/024173

申请日：2005-07-08

Applicant: PNEUMRX, INC. ,  MCGURK, Erin ,  MATHIS, Mark ,  DIECK, Ronald ,  WARTCHOW, Charles

Inventor： MCGURK, Erin ,  MATHIS, Mark ,  DIECK, Ronald ,  WARTCHOW, Charles

IPC: A61B17/08

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/0065 ,  A61B2017/00654

Abstract: This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.

Abstract translation: 本发明一般涉及用于安全地进行经胸手术的肺部装置的设计。 特别地，本发明提供了使用这些装置以最小的导致气胸或血胸风险的方式来接近胸腔的装置和方法。 更具体地，本发明使得能够使用大孔器械诊断和治疗进入胸腔。 本发明还提供了一种诊断和治疗方法，该方法使用能够在装置取出时密封伤口的装置。 本发明包括一种装置，包括适于通过进入孔与受试者的组织接触的细长主体和密封剂递送元件。 本发明还包括在受试者中进行组织治疗或诊断的方法。

公开(公告)号：WO2006014567A2

公开(公告)日：2006-02-09

申请号：PCT/US2005024172

申请日：2005-07-08

Applicant: PNEUMRX INC ,  MCGURK ERIN ,  DIECK RONALD ,  WARTCHOW CHARLES ,  GONG GLEN ,  BALCETA JOBERT

Inventor： MCGURK ERIN ,  DIECK RONALD ,  WARTCHOW CHARLES ,  GONG GLEN ,  BALCETA JOBERT

IPC: A61B17/08

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0074 ,  A61M31/00 ,  A61M2025/0073

Abstract: The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.

Abstract translation: 本发明公开了一种治疗患者胸腔积液的方法，包括将粘合剂材料经皮递送至患者的胸膜腔。 用于实施本发明方法的任何实施方案的合适的粘合剂材料可以选自水凝胶，胶原，聚（乳酸），聚（乙交酯），氰基丙烯酸酯，戊二醛，PEG，蛋白质和多糖及衍生物 它们。 本发明还公开了一种胸腔积液治疗装置，其包括适于粘附限定胸膜腔的胸膜的粘合剂材料和适于将粘合剂材料输送到胸膜腔的胸膜空间进入构件。

公开(公告)号：WO2007008229A2

公开(公告)日：2007-01-18

申请号：PCT/US2005/030717

申请日：2005-08-30

Applicant: PNEUMRX, INC. ,  McGURK, Erin ,  MATHIS, Mark ,  DIECK, Ronald ,  WARTCHOW, Charles

Inventor： McGURK, Erin ,  MATHIS, Mark ,  DIECK, Ronald ,  WARTCHOW, Charles

IPC: A61B17/08

CPC classification number: A61B17/00491 ,  A61B17/0057 ,  A61B17/32002 ,  A61B17/34 ,  A61B17/3415 ,  A61B2017/00278 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/00641 ,  A61B2017/00809

Abstract: This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.

Abstract translation: 本发明一般涉及用于安全执行经胸手术的肺装置的设计。 具体而言，本发明提供了使用这些装置进入胸腔的装置和方法，其造成气胸或血胸的风险最小。 更具体地说，本发明能够使用大口径器械诊断和治疗进入胸腔。 本发明还提供了一种使用能够在器械撤回时密封伤口的装置的诊断和治疗程序的方法。 本发明包括一种装置，该装置包括适于通过进入孔与受试者的组织接触的细长主体，以及密封剂输送元件。 本发明还包括在受试者中进行组织治疗或诊断的方法。

公开(公告)号：WO2006009699A2

公开(公告)日：2006-01-26

申请号：PCT/US2005/020993

申请日：2005-06-13

Applicant: PNEUMRX, INC. ,  GONG, Glen ,  DIECK, Ronald

Inventor： GONG, Glen ,  DIECK, Ronald

IPC: A61K38/54

CPC classification number: A61K49/0008

Abstract: The present invention relates to methods and compositions for targeting damaged lung tissue. Compositions provided feature a targeting moiety coupled to one or more other moieties, including, for example, a cross-linkable moiety, an imaging moiety, and/or one or more other targeting moieties. The methods and compositions of the invention find use, for example, in detecting and treating a pulmonary condition such as emphysema.

Abstract translation: 本发明涉及用于靶向损伤的肺组织的方法和组合物。 提供的组合物具有与一个或多个其它部分偶联的靶向部分，包括例如可交联部分，成像部分和/或一个或多个其它靶向部分。 本发明的方法和组合物可用于例如检测和治疗诸如肺气肿的肺部疾病。

公开(公告)号：WO2006009682A3

公开(公告)日：2006-01-26

申请号：PCT/US2005/020902

申请日：2005-06-13

Applicant: PNEUMRX, INC. ,  GONG, Glen ,  DIECK, Ronald

Inventor： GONG, Glen ,  DIECK, Ronald

IPC: A61K38/00 ,  A61K49/00 ,  C12N9/66

Abstract: The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

公开(公告)号：WO2006009682A2

公开(公告)日：2006-01-26

申请号：PCT/US2005020902

申请日：2005-06-13

Applicant: PNEUMRX INC ,  GONG GLEN ,  DIECK RONALD

Inventor： GONG GLEN ,  DIECK RONALD

IPC: A61K38/54 ,  A61K38/55 ,  A61K39/395 ,  A61K47/48 ,  A61L24/00 ,  A61L24/10

CPC classification number: A61K38/166 ,  A61K35/74 ,  A61K38/14 ,  A61K38/49 ,  A61K38/57 ,  A61K45/06 ,  A61K47/66 ,  A61L24/0015 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/40 ,  B82Y5/00 ,  C12Y304/21031 ,  A61K2300/00

Abstract: The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

Abstract translation: 本发明涉及用于密封损伤的肺组织的局部区域以减少整体肺容积的方法和组合物。 粘合剂组合物提供了胶粘剂，其特征在于连接至一个或多个其它部分的粘合部分，包括例如可交联部分和/或一个其它粘合部分。 本发明的方法和组合物可用于例如治疗肺部疾病如肺气肿。

公开(公告)号：WO1996018343A1

公开(公告)日：1996-06-20

申请号：PCT/US1995016022

申请日：1995-12-12

Applicant: MICRO INTERVENTIONAL SYSTEMS, INC. ,  McGURK, Erin ,  DIECK, Ronald ,  TREMULIS, William, S.

Inventor： MICRO INTERVENTIONAL SYSTEMS, INC.

IPC: A61B17/00

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/12077 ,  A61F2002/30093 ,  A61F2210/0019

Abstract: An embolic element (10) comprises a filament composed of a shape memory material having an unexpanded coil configuration and an expanded random matrix configuration. The embolic element (10) may be delivered to a blood vessel (BV) treatment site in its coiled configuration over a delivery wire (30) through a guide catheter (44). Usually, the coiled embolic element (10) will be disposed over a helical section of the delivery wire (30) prior to release. In that way, proper positioning of the embolic element (10) is then expanded to its enlarged configuration by heating or otherwise exposing to a temperature over the transition temperature of the shape memory material.

Abstract translation: 栓塞元件（10）包括由具有未膨胀线圈构型和膨胀随机矩阵构型的形状记忆材料构成的细丝。 栓塞元件（10）可以通过引导导管（44）在输送线（30）上被递送到其螺旋形构造的血管（BV）治疗部位。 通常，卷绕的栓塞元件（10）将在释放之前设置在输送线（30）的螺旋部分上方。 以这种方式，然后通过加热或以其它方式暴露于超过形状记忆材料的转变温度的温度将栓塞元件（10）的适当定位扩大到其放大构型。

公开(公告)号：WO2006009699A3

公开(公告)日：2007-03-22

申请号：PCT/US2005020993

申请日：2005-06-13

Applicant: PNEUMRX INC ,  GONG GLEN ,  DIECK RONALD

Inventor： GONG GLEN ,  DIECK RONALD

IPC: A61K38/00 ,  A61K49/00 ,  C12N9/66

CPC classification number: A61K49/0008

Abstract: The present invention relates to methods and compositions for targeting damaged lung tissue. Compositions provided feature a targeting moiety coupled to one or more other moieties, including, for example, a cross-linkable moiety, an imaging moiety, and/or one or more other targeting moieties. The methods and compositions of the invention find use, for example, in detecting and treating a pulmonary condition such as emphysema.

Abstract translation: 本发明涉及用于靶向损伤的肺组织的方法和组合物。 提供的组合物具有与一个或多个其它部分偶联的靶向部分，包括例如可交联部分，成像部分和/或一个或多个其它靶向部分。 本发明的方法和组合物可用于例如检测和治疗诸如肺气肿的肺部疾病。

公开(公告)号：WO2006014567A3

公开(公告)日：2006-02-09

申请号：PCT/US2005/024172

申请日：2005-07-08

Applicant: PNEUMRX, INC. ,  MCGURK, Erin ,  DIECK, Ronald ,  WARTCHOW, Charles ,  GONG, Glen ,  BALCETA, Jobert

Inventor： MCGURK, Erin ,  DIECK, Ronald ,  WARTCHOW, Charles ,  GONG, Glen ,  BALCETA, Jobert

IPC: A61B17/08 ,  A61K38/00

Abstract: The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.