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公开(公告)号：WO2019236915A1
公开(公告)日：2019-12-12
申请号：PCT/US2019/035882
申请日：2019-06-06
申请人： PROGENITY, INC. , JONES, Mitchell Lawrence , HARRIS, Todd Louis , BOWEN, John Paul , PHILIPPSEN, Aaron Olafur Laurence , SHIMIZU, Jeffrey A. , SINGH, Sharat
发明人： JONES, Mitchell Lawrence , HARRIS, Todd Louis , BOWEN, John Paul , PHILIPPSEN, Aaron Olafur Laurence , SHIMIZU, Jeffrey A. , SINGH, Sharat
摘要： An ingestible device includes a sample chamber configured to hold a sample, the sample chamber including a base having an aperture; a fluorometer separated from the sample chamber by the sample chamber base, the fluorometer including (I) a light source configured to emit excitation light, (II) a light guide configured to guide the excitation light from the light source to the sample, (III) a photodetector configured to detect emission light generated via the interaction of the excitation light with the sample. The photodetector is configured to receive the emission light from the sample through the aperture. Additionally, the fluorometer includes (IV) an emission filter between the aperture and the photodetector, the emission filter configured to (i) transmit the emission light incident thereon, and (ii) block excitation light incident thereon. In addition, the ingestible device includes a housing that houses the sample chamber and the fluorometer.
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公开(公告)号：WO2019195346A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025462
申请日：2019-04-02
申请人： PROGENITY, INC.
IPC分类号： C12Q1/6806 , C12Q1/682 , C12Q1/6848 , C12Q1/6874 , C12Q1/6876
摘要： Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.
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公开(公告)号：WO2019055661A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050893
申请日：2018-09-13
申请人： PROGENITY, INC.
发明人： COOPER, Matthew , SINGH, Sharat , COPELAND, Karen A. F. , HESTERBERG, Lyndal , MAZLOOM, Amin R. , ABBASI, Mohammad , GIULIO DEL MASTRO, Richard
IPC分类号： G01N33/68
摘要： Disclosed herein are methods, kits, tests, and systems for detecting, predicting, monitoring, or ruling out preeclampsia in pregnant women. Also provided herein are novel diagnostic markers, methods of data analysis, assay formats, and kits employing such markers to improve one or more characteristics of a test for identifying or ruling out preeclampsia based on biomarkers from patient samples.
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公开(公告)号：WO2018112255A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/066512
申请日：2017-12-14
申请人： PROGENITY INC.
摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunosuppressant.
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公开(公告)号：WO2018112223A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/066459
申请日：2017-12-14
申请人： PROGENITY INC.
摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a TLR agonist.
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公开(公告)号：WO2018111325A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/025102
申请日：2017-03-30
申请人： PROGENITY INC.
IPC分类号： A61K39/395 , A61M31/00 , A61B5/00
摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an IL-6R inhibitor.
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公开(公告)号：WO2018111322A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/025059
申请日：2017-03-30
申请人： PROGENITY INC.
摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an integrin inhibitor.
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8.发明申请
公开(公告)号：WO2022087313A1
公开(公告)日：2022-04-28
申请号：PCT/US2021/056111
申请日：2021-10-21
申请人： PROGENITY, INC.
摘要： This disclosure features methods for treating and predicting non-response to anti-TNFα treatment in subjects with a disease of the gastrointestinal tract.
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公开(公告)号：WO2019246317A9
公开(公告)日：2019-12-26
申请号：PCT/US2019/038063
申请日：2019-06-19
申请人： PROGENITY, INC.
发明人： JONES, Mitchell Lawrence , WAHL, Christopher Loren , SINGH, Sharat , HOWE, Kevin David , PERERA, Aruna
IPC分类号： A61K9/22 , A61K31/436 , A61K48/00
摘要： This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.
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公开(公告)号：WO2019246317A1
公开(公告)日：2019-12-26
申请号：PCT/US2019/038063
申请日：2019-06-19
申请人： PROGENITY, INC.
发明人： JONES, Mitchell Lawrence , WAHL, Christopher Loren , SINGH, Sharat , HOWE, Kevin David , PERERA, Aruna
IPC分类号： A61K9/22 , A61K31/436 , A61K48/00
摘要： This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.
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