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    测序方法、测序数据处理方法、设备和计算机设备
    4.
    发明申请
    测序方法、测序数据处理方法、设备和计算机设备 审中-公开

    公开(公告)号：WO2023066255A1

    公开(公告)日：2023-04-27

    申请号：PCT/CN2022/125967

    申请日：2022-10-18

    Applicant: 深圳市真迈生物科技有限公司

    Inventor： 樊济才 ,  金欢 ,  陈美容 ,  陈方 ,  孙雷

    IPC: C12Q1/6837 ,  C12Q1/6874 ,  G16B20/30 ,  G16B20/50

    Abstract: 涉及测序数据处理方法、设备、计算设备和计算机可读介质。测序数据包括多个读段组，读段组包括多个读段，多个读段是通过对同一插入片段进行多轮测序而获得的，测序数据处理方法包括将多个读段与参考基因组进行全局比对，以便在参考基因组上确定与多个读段对应的多个匹配区域；和基于多个匹配区域之间的实际相对位置与预设位置要求的比较，对多个读段进行一次筛选，以便获得可拼接读段和过滤读段，其中，预设位置要求是由多轮测序的规则确定的，实际相对位置满足预设位置要求是读段作为可拼接读段的指示；和实际相对位置不满足预设位置要求是读段作为过滤读段的指示。能够有效地对来自同一插入片段多轮测序的读段进行筛选。

    METHODS FOR PREPARING SUBSTRATE SURFACE FOR DNA SEQUENCING
    5.
    发明申请
    METHODS FOR PREPARING SUBSTRATE SURFACE FOR DNA SEQUENCING 审中-公开

    公开(公告)号：WO2023004357A1

    公开(公告)日：2023-01-26

    申请号：PCT/US2022/073955

    申请日：2022-07-20

    Applicant: ILLUMINA, INC.

    Inventor： BLACK, Hayden ,  LESSARD-VIGER, Mathieu ,  TSAY, James

    IPC: C12Q1/6806 ,  C12Q1/6874

    Abstract: Embodiments of the present disclosure relate to method of preparing a substrate for sequencing by synthesis, including capturing library DNA to the surface using a low salt buffer solution prior to grafting primer oligonucleotides. Substrates prepared by the method described herein have increased monoclonality of clusters and sequencing by synthesis using the substrate prepared by the method are also described.

    METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：WO2022271701A2

    公开(公告)日：2022-12-29

    申请号：PCT/US2022/034346

    申请日：2022-06-21

    Applicant: RETICULA, INC.

    Inventor： WHITEFORD, Nava Edmond

    IPC: C12Q1/6869 ,  C12Q1/6816 ,  C12Q1/6876 ,  C12Q1/48 ,  C12Q1/6874

    Abstract: The present disclosure in some aspects relates to real-time nucleic acid sequencing comprising one or more detectable label deactivation steps, such as stochastic photobleaching that occurs during sequential nucleotide incorporation in a sequencing -by- synthesis reaction. Deactivation of the detectable label(s) of a particular labeled nucleotide may occur prior to, during, and/or after the incorporation of the next nucleotide, for instance, a labeled nucleotide that forms a phosphodiester bond with the particular labeled nucleotide. Also described herein are methods of analyzing sequencing data obtained from the sequencing methods.

    NTEGRATED CIRCUIT WITH 2D FETS FOR DIRECT AND INDIRECT TARGET SIGNAL MEASUREMENT
    8.
    发明申请
    NTEGRATED CIRCUIT WITH 2D FETS FOR DIRECT AND INDIRECT TARGET SIGNAL MEASUREMENT 审中-公开

    公开(公告)号：WO2022246261A2

    公开(公告)日：2022-11-24

    申请号：PCT/US2022/030348

    申请日：2022-05-20

    Applicant: CARDEA BIO, INC.

    Inventor： ARAN, Kiana ,  GOLDSMITH, Brett ,  KANE, Alexander ,  PAYTAVI, Regis

    IPC: G01N27/414 ,  C12Q1/04 ,  C12Q1/6874 ,  H01L27/085

    Abstract: A system (100) and apparatus (130, 1200) for direct or indirect target substance signal measurement include an integrated circuit (101) with an array (103) of 2D FETs (106) with corresponding 2D transistor channels (128) and a gate area (123) for receiving a volume of liquid (120) with one or more chemical or biological target substances (113), a conductive source (104) electrically coupled to a first end of the 2D transistor channel, a conductive drain (107) electrically coupled to a second end of the 2D transistor channel, a ceramic coating over the conductive source and the conductive drain and a thin film layer of synthetic biopolymer specific binding agents (822) is adsorbed to the top surface of the 2D transistor channel. Methods (1300, 1400, 1500, 1600) for the system and apparatus and for selecting the synthetic biopolymer specific binding agents based on absorptivity are disclosed.

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