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    ARTIFICIAL NUCLEUS PULPOSUS AND METHOD OF INJECTING SAME
    2.
    发明申请
    ARTIFICIAL NUCLEUS PULPOSUS AND METHOD OF INJECTING SAME 审中-公开
    人造髓核及其注射方法

    公开(公告)号：WO2004064673A9

    公开(公告)日：2004-09-10

    申请号：PCT/US2004001321

    申请日：2004-01-16

    Applicant: PSINERGI CORP ,  DULAK GARY R ,  BHALANI ANIL ,  MOLLOY PAUL A

    Inventor： DULAK GARY R ,  BHALANI ANIL ,  MOLLOY PAUL A

    IPC: A61B17/00 ,  A61F20060101 ,  A61F2/00 ,  A61F2/30 ,  A61F2/44 ,  A61F2/46 ,  A61L27/26 ,  A61F

    CPC classification number: A61F2/4611 ,  A61B17/00234 ,  A61F2/441 ,  A61F2/4601 ,  A61F2002/30088 ,  A61F2002/30583 ,  A61F2002/444 ,  A61F2002/4635 ,  A61F2210/008 ,  A61F2210/0085 ,  A61L27/26

    Abstract: The present invention relates to an artificial nucleus pulposus implant that is injected minimally invasively into the nucleus cavity of the annulus fibrosus to restore the normal anatomical and physiological function of the spine in the affected disc segment. In one aspect of the invention, a device is disclosed for delivering a phase changing biomaterial to a tissue site, the device comprising a dispenser including (i) a plunger having a proximal portion and a distal portion, an inlet end and an outlet end, (ii) a dispensing actuator attached to the proximal portion of the plunger, and (iii) a cartridge adapted to be inserted into the inlet end of the plunger for containing the phase changing biomaterial in a fluid state. The dispenser may be mechanically, pneumatically or hydraulically actuated. The dispenser may further comprise a nozzle attached to the cartridge for dispensing the biomaterial to the tissue site. In another aspect, the device may further comprise a tissue cavity access unit providing a conduit having an inlet end in fluid communication with the nozzle, and an outlet end adapted to deliver the biomaterial to the tissue site. The biomaterial may transition from the fluid state to a solid state after a set amount of time, a temperature change or an exposure to an external stimuli such as radiation, UV light or an electrical stimuli. The cartridge may be a dual-chambered cartridge for storing different fluid biomaterials in the two chambers. In another aspect of the invention, a process for producing the artificial nucleus pulposus implant in the nucleus cavity of the annulus fibrosus is disclosed, the process comprising the steps of (a) obtaining access to the nucleus cavity; (b) injecting the artificial nucleus pulposus into the nucleus cavity; and (c) permitting the biomaterial to transition from a fluid state to a solid state in-situ after a given condition.

    Abstract translation: 本发明涉及人造髓核植入物，其被微创地侵入到纤维环的髓核腔中，以恢复受影响的椎间盘节段中脊柱的正常解剖和生理功能。 在本发明的一个方面中，公开了一种用于将相变生物材料递送至组织部位的装置，该装置包括分配器，该分配器包括（i）具有近端部分和远端部分，入口端和出口端的柱塞， （ii）连接到柱塞的近侧部分的分配致动器，以及（iii）适于插入柱塞的入口端以用于容纳处于流体状态的相变生物材料的筒。 分配器可以机械地，气动地或液压地致动。 分配器可进一步包括附接到药筒的喷嘴，用于将生物材料分配到组织部位。 在另一方面，该装置可进一步包括组织空腔通路单元，其提供具有与喷嘴流体连通的入口端和适于将生物材料递送至组织部位的出口端的导管。 在设定的时间量，温度变化或暴露于诸如辐射，UV光或电刺激的外部刺激之后，生物材料可以从流体状态转变为固态。 盒可以是用于在两个腔室中存储不同的流体生物材料的双腔盒。 在本发明的另一方面中，公开了一种用于在纤维环的髓核中产生人造髓核植入物的方法，该方法包括以下步骤：（a）进入髓核腔; （b）将人造髓核注入髓核腔; 和（c）允许生物材料在给定条件后原位从流体状态过渡到固态。

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