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    OPTIMIZING TOTAL ENERGY DELIVERED IN NANOSECOND PULSES FOR TRIGGERING APOPTOSIS IN CULTURED CELLS
    3.
    发明申请
    OPTIMIZING TOTAL ENERGY DELIVERED IN NANOSECOND PULSES FOR TRIGGERING APOPTOSIS IN CULTURED CELLS 审中-公开
    优化纳米脉冲能量传递细胞诱导培养细胞凋亡的能量

    公开(公告)号：WO2017201394A1

    公开(公告)日：2017-11-23

    申请号：PCT/US2017/033522

    申请日：2017-05-19

    Applicant: PULSE BIOSCIENCES, INC.

    Inventor： NUCCITELLI, Richard ,  MALLON, Zachary R. ,  MCDANIEL, Amanda H. ,  DANITZ, David J. ,  ATHOS, Brian G. ,  KREIS, Mark P. ,  UECKER, Darrin R. ,  NUCCITELLI, Pamela S.

    IPC: A61N1/36 ,  A61B18/00

    CPC classification number: A61B18/14 ,  A61B5/055 ,  A61B2018/00613 ,  A61B2018/1405 ,  A61N1/327 ,  A61N1/36002

    Abstract: An optimization of electrical characteristics for treatments of tumor or other abnormal cells in culture with sub-microsecond, high-electric field electrical pulses is disclosed. The voltages, pulse widths, and number of pulses are chosen such that the treatment energy is 10-20 J/mL. That is, U = n * Δt * V * I / volume is 10-20 J/mL, in which n is the number of pulses, Δt is the duration of each pulse, V is the voltage, I is current, and volume is the area of parallel electrodes times the distance between them. V divided by the distance between the electrodes can be in an effective range of 6 kV/cm to 30 kV/cm, 60 kV/cm, 100 kV/cm, or higher intensities. Rows of needle electrodes, blade electrodes, or other configurations of electrodes can approximate parallel electrodes.

    Abstract translation: 公开了用亚微秒高电场电脉冲治疗肿瘤或其他异常细胞的电特性的优化。 选择电压，脉冲宽度和脉冲数以使处理能量为10-20J / mL。 也就是说，U = n *Δt* V * I /体积为10-20 J / mL，其中n为脉冲数，Δt为每个脉冲的持续时间，V为电压，I为电流，体积 平行电极的面积乘以它们之间的距离。 V除以电极之间的距离可以处于6kV / cm至30kV / cm，60kV / cm，100kV / cm或更高强度的有效范围内。 针电极，刀片电极或其他电极配置的行可以接近平行电极。

    HIGH-VOLTAGE ANALOG CIRCUIT PULSER WITH FEEDBACK CONTROL
    6.
    发明申请
    HIGH-VOLTAGE ANALOG CIRCUIT PULSER WITH FEEDBACK CONTROL 审中-公开
    具有反馈控制的高压模拟电路脉冲

    公开(公告)号：WO2017151261A1

    公开(公告)日：2017-09-08

    申请号：PCT/US2017/015884

    申请日：2017-01-31

    Applicant: PULSE BIOSCIENCES, INC.

    Inventor： XIAO, Shu ,  ATHOS, Brian G. ,  KREIS, Mark P. ,  DANITZ, David J. ,  UECKER, Darrin R.

    IPC: H03K3/02

    Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.

    Abstract translation: 公开了一种亚微秒脉冲电场发生器。 场发生器包括产生电源控制信号并产生脉冲发生器控制信号的控制器，以及接收电源控制信号并基于接收的电源控制信号产生一个或多个电源电压的电源。 场发生器还包括脉冲发生器，其接收功率电压和脉冲发生器控制信号，并基于功率电压并基于脉冲发生器控制信号产生一个或多个脉冲。 控制器接收表示脉冲特征值或脉冲结果值的反馈信号，并基于接收到的反馈信号产生电源控制信号和脉冲发生器控制信号中的至少一个。

    LOW-VOLTAGE IMPEDANCE CHECK PULSE GENERATOR
    7.
    发明申请
    LOW-VOLTAGE IMPEDANCE CHECK PULSE GENERATOR 审中-公开
    低压阻抗检测脉冲发生器

    公开(公告)号：WO2018089506A1

    公开(公告)日：2018-05-17

    申请号：PCT/US2017/060654

    申请日：2017-11-08

    Applicant: PULSE BIOSCIENCES, INC.

    Inventor： ATHOS, Brian G. ,  DANITZ, David J. ,  KREIS, Mark P. ,  UECKER, Darrin R.

    IPC: A61N1/40 ,  A61B18/12

    Abstract: Methods and systems for testing a pulse generator circuit are disclosed. The methods include calculating one or more impedances of a load from applied pulses and comparing the one or more impedances with an expected impedance. The results of the comparison are used to determine whether the pulse generator system is working properly, whether the therapeutic treatment may be initiated or continued, or whether parameters of the pulses should be changed. The pulses may be therapeutic or test pulses, and they may have various parameters of voltage, duration, frequency, or any other electrical parameter. The methods of the disclosure may be performed by a treatment system comprising a controller.

    Abstract translation: 公开了用于测试脉冲发生器电路的方法和系统。 该方法包括根据施加的脉冲计算负载的一个或多个阻抗并将一个或多个阻抗与预期阻抗进行比较。 比较结果用于确定脉冲发生器系统是否正常工作，治疗处理是否可以开始或继续，或脉冲参数是否应该改变。 脉冲可以是治疗或测试脉冲，并且它们可以具有电压，持续时间，频率或任何其他电参数的各种参数。 本公开的方法可以由包括控制器的治疗系统执行。

    HIGH VOLTAGE CONNECTORS AND ELECTRODES FOR PULSE GENERATORS
    8.
    发明申请
    HIGH VOLTAGE CONNECTORS AND ELECTRODES FOR PULSE GENERATORS 审中-公开
    用于脉冲发生器的高压连接器和电极

    公开(公告)号：WO2018053539A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/052340

    申请日：2017-09-19

    Applicant: PULSE BIOSCIENCES, INC.

    Inventor： KREIS, Mark P. ,  DANITZ, David J. ,  HINMAN, Cameron D. ,  FINSON, Sean N.

    IPC: A61B18/14 ,  A61N1/04 ,  A61N1/32

    Abstract: A handheld, therapeutic electrode and connector that are compatible with high voltages from a pulse generator are disclosed. The electrode includes therapeutic terminals on a tip configured to deliver high voltage pulses safely to a patient. The electrode includes sleeves, bosses, wiring channels, and other features that maximize a minimum clearance distance (across non-conductive surfaces) and air clearance between conductive connectors themselves or the connectors and a user, thus preventing dangerous arcing. Internal surfaces and seams are taken into account. The connector and its mating outlet can include similar features to maximize clearance distance. Skirts, skirt holes, and finger stops are also employed, and they can be on either the connector or outlet, or the tip or handle of the electrode.

    Abstract translation: 公开了一种与来自脉冲发生器的高电压兼容的手持式治疗电极和连接器。 电极包括配置为向患者安全输送高电压脉冲的尖端上的治疗端子。 电极包括套管，凸台，接线通道以及其他可使导电连接器本身或连接器与使用者之间的最小间隙距离（跨过非导电表面）和空气间隙最大化的特征，从而防止危险的电弧放电。 考虑内部表面和接缝。 连接器及其配合出口可以包括类似的特征以最大化间隙距离。 也可以使用裙子，裙孔和手指挡块，它们可以位于连接器或插座上，也可以位于电极的尖端或手柄上。

    PULSE APPLICATOR
    9.
    发明申请
    PULSE APPLICATOR 审中-公开
    脉冲施加器

    公开(公告)号：WO2017200954A1

    公开(公告)日：2017-11-23

    申请号：PCT/US2017/032744

    申请日：2017-05-15

    Applicant: PULSE BIOSCIENCES, INC.

    Inventor： KREIS, Mark P. ,  DANITZ, David J. ,  HINMAN, Cameron D.

    IPC: A61B18/14 ,  A61B18/12 ,  A61N1/05 ,  A61N1/18

    Abstract: The pulse applicator includes a first arm, including a first electrode, a second arm, including a second electrode, and a spacer. The first arm, the spacer, and the second arm are movably connected, and define a gap between the first arm and the second arm. The first electrode, the gap, and the second electrode are selectively alignable, and the first electrode and the second electrode are configured to deliver an electrical field across the gap in response to an electrical pulse received across the first and second electrodes.

    Abstract translation: 脉冲施加器包括第一臂和第二电极，第一臂包括第一电极，第二臂包括第二电极和间隔件。 第一臂，间隔件和第二臂可移动地连接，并限定第一臂和第二臂之间的间隙。 所述第一电极，所述间隙和所述第二电极可选择性地对准，并且所述第一电极和所述第二电极被配置为响应于跨所述第一和第二电极接收的电脉冲而在所述间隙上传递电场。 >

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