公开(公告)号：WO2021045836A1

公开(公告)日：2021-03-11

申请号：PCT/US2020/039707

申请日：2020-06-25

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： BABB, Robert ,  BAUM, Alina ,  CHEN, Gang ,  GERSON, Cindy ,  HANSEN, Johanna ,  HUANG, Tammy ,  KYRATSOUS, Christos ,  LEE, Wen-Yi ,  MALBEC, Marine ,  MURPHY, Andrew ,  OLSON, William ,  STAHL, Neil ,  YANCOPOULOS, George, D.

IPC: A61K39/215 ,  A61K39/395 ,  A61K45/06 ,  C07K16/10

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections). The present disclosure provides neutralizing human antigen-binding proteins that specifically bind to SARS-CoV-2-S, for example, antibodies or antigen-binding fragments thereof.