公开(公告)号：WO2020086647A8

公开(公告)日：2020-04-30

申请号：PCT/US2019/057543

申请日：2019-10-23

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： BABB, Robert ,  BOWERMAN, Natalie ,  CHEN, Gang ,  GURER, Cagan ,  HANSEN, Johanna ,  LEE, Wen-Yi ,  MEAGHER, Thomas

IPC: C07K14/725

Abstract: The present invention provides isolated T cell receptors (TCRs) that specifically bind to an HLA-displayed New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) peptides, as well as therapeutic and diagnostic methods of using those isolated TCRs.

公开(公告)号：WO2022140494A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/064769

申请日：2021-12-22

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： CHEN, Gang ,  SHI, Ergang ,  LEE, Wen-Yi ,  SUH, David ,  FARR, Glen ,  BABB, Robert

IPC: C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  G01N33/68

Abstract: Disclosed are methods for obtaining cells that express antibodies that bind transmembrane proteins, methods for generating antibodies from such cells, antibodies to transmembrane proteins and fragments thereof, and nucleic acids encoding the antibodies. More particularly, the disclosure relates to methods for obtaining antibody-producing cells that express an antibody that binds to a transmembrane protein based on the use of lipid bilayer-membrane scaffold protein complexes to present transmembrane protein antigens to cells.

公开(公告)号：WO2021045836A1

公开(公告)日：2021-03-11

申请号：PCT/US2020/039707

申请日：2020-06-25

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： BABB, Robert ,  BAUM, Alina ,  CHEN, Gang ,  GERSON, Cindy ,  HANSEN, Johanna ,  HUANG, Tammy ,  KYRATSOUS, Christos ,  LEE, Wen-Yi ,  MALBEC, Marine ,  MURPHY, Andrew ,  OLSON, William ,  STAHL, Neil ,  YANCOPOULOS, George, D.

IPC: A61K39/215 ,  A61K39/395 ,  A61K45/06 ,  C07K16/10

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections). The present disclosure provides neutralizing human antigen-binding proteins that specifically bind to SARS-CoV-2-S, for example, antibodies or antigen-binding fragments thereof.

公开(公告)号：WO2020086647A1

公开(公告)日：2020-04-30

申请号：PCT/US2019/057543

申请日：2019-10-23

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： BABB, Robert ,  BOWERMAN, Natalie ,  CHEN, Gang ,  GURER, Cagan ,  HANSEN, Johanna ,  LEE, Wen-Yi ,  MEAGHER, Thomas

IPC: C07K14/725

Abstract: The present invention provides isolated T cell receptors (TCRs) that specifically bind to an H LA-displayed New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) peptides, as well as therapeutic and diagnostic methods of using those isolated TCRs.